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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

The Journal of pharmacology and experimental therapeutics, 1996-12, Vol.279 (3), p.1453

1996

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Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration

The Journal of biological chemistry, 1998-04, Vol.273 (17), p.10095-10098

1998

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IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-γ-deficient mice in a Th2-biased response

Cellular Immunology, 2006-06, Vol.241 (2), p.66-74

2006

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Identification of interleukin-13 related biomarkers using peripheral blood mononuclear cells

Biomarkers, 2007-07, Vol.12 (4), p.414-423

2007

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Inhibition of p38 MAP kinase as a therapeutic strategy

Immunopharmacology, 2000-05, Vol.47 (2-3), p.185-201

2000

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Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification

Journal of neuroscience research, 1991-07, Vol.29 (3), p.336-345

1991

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Biopharmaceutical therapeutics for asthma remodeling

Current pharmaceutical design, 2006-09, Vol.12 (25), p.3233-3240

2006

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Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic

Pulmonary pharmacology & therapeutics, 1999, Vol.12 (2), p.131-135

1999

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Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia

Stroke (1970), 1992-09, Vol.23 (9), p.1337-1347

1992

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SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

American journal of physiology. Lung cellular and molecular physiology, 2000-11, Vol.279 (5), p.895-L902

2000

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1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.3929-3937

1996

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Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family

The Journal of biological chemistry, 2000-04, Vol.275 (14), p.10308-10314

2000

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Role of chemokines in severe asthma

Current drug targets, 2006-05, Vol.7 (5), p.579-588

2006

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Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date

Medicinal research reviews, 1996-03, Vol.16 (2), p.181-206

1996

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Intralesional Cytokines in Chronic Oxazolone-Induced Contact Sensitivity Suggest Roles for Tumor Necrosis Factor α and Interleukin-4

Journal of investigative dermatology, 1998-07, Vol.111 (1), p.86-92

1998

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SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence

The Journal of pharmacology and experimental therapeutics, 2000-04, Vol.293 (1), p.281

2000

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Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors

Annals of the New York Academy of Sciences, 1993-11, Vol.696 (1), p.149-170

1993

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Regulation of antigen-specific versus by-stander IgE production after antigen sensitization

Cellular immunology, 2004-06, Vol.229 (2), p.106-116

2004

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Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

The Journal of pharmacology and experimental therapeutics, 1998-02, Vol.284 (2), p.687

1998

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Temporal relation between neutrophil accumulation and myocardial reperfusion injury

American journal of physiology. Heart and circulatory physiology, 1988-11, Vol.255 (5), p.H1060-H1068

1988

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Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Bioorganic & medicinal chemistry letters, 1998-11, Vol.8 (22), p.3111-3116

1998

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Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation

The Journal of pharmacology and experimental therapeutics, 1994-02, Vol.268 (2), p.709

1994

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Role of complement in endotoxin/platelet-activating factor-induced lung injury

The Journal of immunology (1950), 1992-09, Vol.149 (5), p.1744-1750

1992

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Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity

Bioorganic & medicinal chemistry letters, 2001-11, Vol.11 (21), p.2867-2870

2001

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Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation

Journal of immunological methods, 2000-06, Vol.240 (1), p.125-132

2000

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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function

Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration

IgE isotype switch and IgE production are enhanced in IL-21-deficient but not IFN-γ-deficient mice in a Th2-biased response

Identification of interleukin-13 related biomarkers using peripheral blood mononuclear cells

Inhibition of p38 MAP kinase as a therapeutic strategy

Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification

Biopharmaceutical therapeutics for asthma remodeling

Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic

Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung

1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency

Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family

Role of chemokines in severe asthma

Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date

Intralesional Cytokines in Chronic Oxazolone-Induced Contact Sensitivity Suggest Roles for Tumor Necrosis Factor α and Interleukin-4

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence

Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors

Regulation of antigen-specific versus by-stander IgE production after antigen sensitization

Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

Temporal relation between neutrophil accumulation and myocardial reperfusion injury

Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

Effects of scalaradial, a type II phospholipase A2 inhibitor, on human neutrophil arachidonic acid mobilization and lipid mediator formation

Role of complement in endotoxin/platelet-activating factor-induced lung injury

Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity

Human granulocyte CD11b expression as a pharmacodynamic biomarker of inflammation

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