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Action of 2',2'-difluorodeoxycytidine on DNA synthesis

Cancer research (Chicago, Ill.), 1991-11, Vol.51 (22), p.6110-6117

1991

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Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

Molecular pharmacology, 1990-10, Vol.38 (4), p.567-572

1990

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Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine)

Cancer research (Chicago, Ill.), 1990-07, Vol.50 (14), p.4417-4422

1990

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Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate : a mechanism of self-potentiation

Cancer research (Chicago, Ill.), 1992-02, Vol.52 (3), p.533-539

1992

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In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin

Anticancer research, 1995-07, Vol.15 (4), p.1135

1995

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A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor or thymidylate synthase

Journal of medicinal chemistry, 1992-11, Vol.35 (23), p.4450-4454

1992

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Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine

Cancer research (Chicago, Ill.), 1988-07, Vol.48 (14), p.4024-4031

1988

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Sulfonimidamide analogs of oncolytic sulfonylureas

Journal of medicinal chemistry, 1997-03, Vol.40 (6), p.1018-1025

1997

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Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models

Investigational new drugs, 1996-01, Vol.14 (3), p.243-247

1996

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Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression

Clinical cancer research, 1996-07, Vol.2 (7), p.1135-1141

1996

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Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

Biochemical pharmacology, 1993-07, Vol.46 (2), p.285-290

1993

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Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts

Biochemical pharmacology, 1996-11, Vol.52 (9), p.1477-1479

1996

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Characterization of the intracellular distribution and binding in human adenocarcinoma cells of N-(4-azidophenyl-sulfonyl)- N′-(4-chlorophenyl)urea (LY219703), a photoaffinity analogue of the antitumor diarylsulfonylurea sulofenur

Biochemical pharmacology, 1995-03, Vol.49 (5), p.661-668

1995

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Synthesis and biological activity of acyclic analogs of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid

Journal of medicinal chemistry, 1992-03, Vol.35 (6), p.1109-1116

1992

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Augmentation of the therapeutic activity of lometrexol [(6-R)5,10-dideazatetrahydrofolate] by oral folic acid

Cancer research (Chicago, Ill.), 1996-05, Vol.56 (10), p.2331-2335

1996

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Effect of albumin on antitumor activity of diarylsulfonylureas

Anticancer research, 1993-11, Vol.13 (6A), p.1939

1993

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Lack of in vivo crossresistance with gemcitabine against drug-resistant murine P388 leukemias

Cancer chemotherapy and pharmacology, 1996, Vol.38 (2), p.178-180

1996

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Evaluation of new anticancer agents against the MIA PaCa-2 and PANC-1 human pancreatic carcinoma xenografts

Oncology research, 1993, Vol.5 (6-7), p.223

1993

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N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea, a novel agent equally cytotoxic to nonproliferating human colon adenocarcinoma cells

Cancer research (Chicago, Ill.), 1990-01, Vol.50 (2), p.318-322

1990

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Whole-Body Autoradiographic Disposition and Plasma Pharmacokinetics of 5,10-Dideazatetrahydrofolic Acid in Mice Fed Folic Acid-Deficient or Regular Diets

Journal of pharmaceutical sciences, 1994-10, Vol.83 (10), p.1396-1399

1994

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Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues

Cancer chemotherapy and pharmacology, 1994, Vol.34 (4), p.344-350

1994

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Synthesis and biological activity of 2-desamino and 4-deoxy analogs of 5,10-dideazatetrahydrofolic acid (DDATHF)

Bioorganic & medicinal chemistry letters, 1993-12, Vol.3 (12), p.2657-2660

1993

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Activity of 2, 2 -difluorodeoxycytidine (Gemcitabine) against human tumor colony forming units

Anti-cancer drugs, 1992-04, Vol.3 (2), p.143-146

1992

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Effect of 2',2'-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro

Oncology research, 1992, Vol.4 (4-5), p.151

1992

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Comparison of metabolism and toxicity to the structure of the anticancer agent sulofenur and related sulfonylureas

Chemical research in toxicology, 1992-09, Vol.5 (5), p.667-673

1992

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Action of 2',2'-difluorodeoxycytidine on DNA synthesis

Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine)

Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate : a mechanism of self-potentiation

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin

A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor or thymidylate synthase

Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine

Sulfonimidamide analogs of oncolytic sulfonylureas

Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models

Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts

Characterization of the intracellular distribution and binding in human adenocarcinoma cells of N-(4-azidophenyl-sulfonyl)- N′-(4-chlorophenyl)urea (LY219703), a photoaffinity analogue of the antitumor diarylsulfonylurea sulofenur

Synthesis and biological activity of acyclic analogs of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid

Augmentation of the therapeutic activity of lometrexol [(6-R)5,10-dideazatetrahydrofolate] by oral folic acid

Effect of albumin on antitumor activity of diarylsulfonylureas

Lack of in vivo crossresistance with gemcitabine against drug-resistant murine P388 leukemias

Evaluation of new anticancer agents against the MIA PaCa-2 and PANC-1 human pancreatic carcinoma xenografts

N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea, a novel agent equally cytotoxic to nonproliferating human colon adenocarcinoma cells

Whole-Body Autoradiographic Disposition and Plasma Pharmacokinetics of 5,10-Dideazatetrahydrofolic Acid in Mice Fed Folic Acid-Deficient or Regular Diets

Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues

Synthesis and biological activity of 2-desamino and 4-deoxy analogs of 5,10-dideazatetrahydrofolic acid (DDATHF)

Activity of 2, 2 -difluorodeoxycytidine (Gemcitabine) against human tumor colony forming units

Effect of 2',2'-difluorodeoxycytidine on the viability and radiosensitivity of EMT6 cells in vitro

Comparison of metabolism and toxicity to the structure of the anticancer agent sulofenur and related sulfonylureas

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