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Application of cross-species PET imaging to assess neurotransmitter release in brain

PSYCHOPHARMACOLOGY, 2015-11, Vol.232 (21-22), p.4129-4157

2015

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Identification of Multiple 5‑HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9240-9254

2012

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Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors

The Journal of biological chemistry, 2001-06, Vol.276 (22), p.18795-18803

2001

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Meet Our Editorial Board Member

Letters in drug design & discovery, 2015-07, Vol.12 (8), p.613-613

Grimwood, Sarah

2015

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Validation of a rat in vivo [3H]M100907 binding assay to determine a translatable measure of 5-HT2A receptor occupancy

European journal of pharmacology, 2008-09, Vol.591 (1-3), p.136-141

2008

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Target site occupancy: emerging generalizations from clinical and preclinical studies

Pharmacology & therapeutics (Oxford), 2009-06, Vol.122 (3), p.281-301

2009

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The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze

European journal of pharmacology, 2003-08, Vol.476 (3), p.193-199

2003

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Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4568-4579

2013

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.10831-10847

2024

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Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists

Journal of medicinal chemistry, 1997-12, Vol.40 (25), p.4053-4068

1997

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.10831-10847

2024

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Design and Synthesis of γ- and δ‑Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1‑Selective PAM with Weak Agonist Activity

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6649-6663

2017

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Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors

The Journal of pharmacology and experimental therapeutics, 2011-11, Vol.339 (2), p.555-566

2011

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Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist PF-04455242

NeuroImage (Orlando, Fla.), 2014-10, Vol.99, p.69-79

2014

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Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation

Molecular pharmacology, 2011-11, Vol.80 (5), p.920-929

2011

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Characterization of a Novel M 1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [ 3 H]PT-1284

Molecular pharmacology, 2016-09, Vol.90 (3), p.177-187

2016

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Design and optimization of selective azaindole amide M 1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.650-655

2016

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Electrophysiological recordings in rats performing the sustained attention task

The FASEB journal, 2013-04, Vol.27 (S1)

2013

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Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation

Biochemistry (Easton), 2016-12, Vol.55 (51), p.7073-7085

2016

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Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D.sub.2 Receptor Occupancy

Pharmaceutical research, 2016-05, Vol.33 (5), p.1305

2016

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4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor

Journal of medicinal chemistry, 1992-05, Vol.35 (11), p.1954-1968

1992

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Translational Modeling in Schizophrenia: Predicting Human Dopamine D.sub.2 Receptor Occupancy

Pharmaceutical research, 2016-04, Vol.33 (4)

2016

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Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

European journal of nuclear medicine and molecular imaging, 2017-02, Vol.44 (2), p.308-320

2017

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Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284

Molecular pharmacology, 2016-09, Vol.90 (3), p.177-187

2016

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Application of cross-species PET imaging to assess neurotransmitter release in brain

Identification of Multiple 5‑HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease

Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-d-aspartate Receptors

Meet Our Editorial Board Member

Validation of a rat in vivo [3H]M100907 binding assay to determine a translatable measure of 5-HT2A receptor occupancy

Target site occupancy: emerging generalizations from clinical and preclinical studies

The effect of (±)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor

Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor

Discovery of the Potent and Selective M1 PAM-Agonist N‑[(3R,4S)‑3-Hydroxytetrahydro‑2H‑pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Design and Synthesis of γ- and δ‑Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1‑Selective PAM with Weak Agonist Activity

Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors

Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist PF-04455242

Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation

Characterization of a Novel M 1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [ 3 H]PT-1284

Design and optimization of selective azaindole amide M 1 positive allosteric modulators

Electrophysiological recordings in rats performing the sustained attention task

Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation

Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D.sub.2 Receptor Occupancy

4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor

Translational Modeling in Schizophrenia: Predicting Human Dopamine D.sub.2 Receptor Occupancy

Characterization of [11C]Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain

Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284

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