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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America

Drug metabolism and disposition, 2009-07, Vol.37 (7), p.1355-1370

2009

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Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics

British journal of clinical pharmacology, 2006-01, Vol.61 (1), p.58-69

2006

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Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1151-1163

2012

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Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions

Drug metabolism and disposition, 2006-06, Vol.34 (6), p.976-983

2006

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In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics

Drug metabolism and disposition, 2011-04, Vol.39 (4), p.703-710

2011

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Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells

Drug metabolism and disposition, 2010-07, Vol.38 (7), p.1015-1018

2010

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Fusidic Acid Inhibits Hepatic Transporters and Metabolic Enzymes: Potential Cause of Clinical Drug-Drug Interaction Observed with Statin Coadministration

Antimicrobial agents and chemotherapy, 2016-10, Vol.60 (10), p.5986-5994

2016

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Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

Xenobiotica, 2015-03, Vol.45 (3), p.244-255

2015

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Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents

Xenobiotica, 2017-01, Vol.47 (1), p.31-49

2017

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Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine

Drug metabolism and disposition, 2010-05, Vol.38 (5), p.863-870

2010

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A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABAA receptor modulator – an in vitro and in vivo comparison

British journal of clinical pharmacology, 2012-07, Vol.74 (1), p.98-108

2012

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Liquid chromatography–tandem mass spectrometry method for measurement of nicotine N-glucuronide: A marker for human UGT2B10 inhibition

Journal of pharmaceutical and biomedical analysis, 2011-07, Vol.55 (5), p.964-971

2011

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Absorption, excretion, and metabolism of a potential GABA-Aα2/3 receptor modulator in rats

Xenobiotica, 2011-05, Vol.41 (5), p.385-399

2011

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In vitro and in vivo metabolism of a selective δ-opioid receptor

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1883-1894

2011

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A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison

British journal of clinical pharmacology, 2012-07, Vol.74 (1), p.98-108

2012

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In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite

Xenobiotica, 2011-03, Vol.41 (3), p.232-242

2011

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Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase

Drug metabolism and disposition, 1997-05, Vol.25 (5), p.598

1997

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Rapid Classification of CYP3A4 Inhibition Potential Using Support Vector Machine Approach

Letters in drug design & discovery, 2007-04, Vol.4 (3), p.192-200

2007

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Disposition and Metabolism of Ticagrelor, a Novel P2Y 12 Receptor Antagonist, in Mice, Rats, and Marmosets

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1555-1567

2011

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Disposition and metabolism of ticagrelor, a novel P2Y12 receptor antagonist, in mice, rats, and marmosets

Drug metabolism and disposition, 2011-09, Vol.39 (9), p.1555

2011

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In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P 450 enzyme identification, inhibition, and induction studies

Xenobiotica, 2010-11, Vol.40 (11), p.721-729

2010

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A clinical study to assess CYP1 A2 and CYP3A4 induction by AZD7325, a selective GABAA receptor modulator - an in vitro and in vivo comparison

British journal of clinical pharmacology, 2012, Vol.74 (1), p.98-108

2012

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In vitro prediction of potential metabolic drug interactions for seroquel

Schizophrenia research, 1997, Vol.24 (1), p.198-198

1997

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In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P450 enzyme identification, inhibition, and induction studies

Xenobiotica, 2010-11, Vol.40 (11), p.721-729

2010

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In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies

Xenobiotica, 2010-11, Vol.40 (11), p.721-729

2010

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The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America

Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics

Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct

Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions

In vitro evaluation of potential drug-drug interactions with ticagrelor: cytochrome P450 reaction phenotyping, inhibition, induction, and differential kinetics

Expression and characterization of dog cytochrome P450 2A13 and 2A25 in baculovirus-infected insect cells

Fusidic Acid Inhibits Hepatic Transporters and Metabolic Enzymes: Potential Cause of Clinical Drug-Drug Interaction Observed with Statin Coadministration

Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

Absorption, distribution, metabolism and elimination of 14C-ETX0914, a novel inhibitor of bacterial type-II topoisomerases in rodents

Role of human UGT2B10 in N-glucuronidation of tricyclic antidepressants, amitriptyline, imipramine, clomipramine, and trimipramine

A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABAA receptor modulator – an in vitro and in vivo comparison

Liquid chromatography–tandem mass spectrometry method for measurement of nicotine N-glucuronide: A marker for human UGT2B10 inhibition

Absorption, excretion, and metabolism of a potential GABA-Aα2/3 receptor modulator in rats

In vitro and in vivo metabolism of a selective δ-opioid receptor

A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison

In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite

Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase

Rapid Classification of CYP3A4 Inhibition Potential Using Support Vector Machine Approach

Disposition and Metabolism of Ticagrelor, a Novel P2Y 12 Receptor Antagonist, in Mice, Rats, and Marmosets

Disposition and metabolism of ticagrelor, a novel P2Y12 receptor antagonist, in mice, rats, and marmosets

In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P 450 enzyme identification, inhibition, and induction studies

A clinical study to assess CYP1 A2 and CYP3A4 induction by AZD7325, a selective GABAA receptor modulator - an in vitro and in vivo comparison

In vitro prediction of potential metabolic drug interactions for seroquel

In vitro assessment of metabolic drug-drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P450 enzyme identification, inhibition, and induction studies

In vitro assessment of metabolic drug–drug interaction potential of AZD2624, neurokinin-3 receptor antagonist, through cytochrome P(450) enzyme identification, inhibition, and induction studies

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