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Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery

Current opinion in chemical biology, 2020-06, Vol.56, p.111-118

2020

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Natural product fragment combination to performance-diverse pseudo-natural products

Nature communications, 2021-03, Vol.12 (1), p.1883-1883, Article 1883

2021

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Dynamic Catalytic Highly Enantioselective 1,3‐Dipolar Cycloadditions

Angewandte Chemie International Edition, 2021-09, Vol.60 (36), p.20012-20020

International ed. in English, 2021

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Chemical Evolution of Natural Product Structure

Journal of the American Chemical Society, 2022-03, Vol.144 (8), p.3314-3329

2022

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Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype

Advanced science, 2021-10, Vol.8 (19), p.e2102042-n/a

2021

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Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling

Advanced science, 2024-06, Vol.11 (21), p.e2309202-n/a

2024

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Spacial ScoreA Comprehensive Topological Indicator for Small-Molecule Complexity

Journal of medicinal chemistry, 2023-09, Vol.66 (18), p.12739-12750

2023

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Dynamic Catalytic Highly Enantioselective 1,3‐Dipolar Cycloadditions

Angewandte Chemie, 2021-09, Vol.133 (36), p.20165-20173

2021

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Progress and opportunities of pseudo-natural-product design in molecular discovery

ARKIVOC free online journal of organic chemistry, 2024-01, Vol.2024 (5)

2024

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Phenotypic profiling enables the targeted design of a novel pseudo-natural product class

Tetrahedron, 2023-08, Vol.143, p.133553, Article 133553

2023

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Single-Flask Multicomponent Synthesis of Highly Substituted α‑Pyrones via a Sequential Enolate Arylation and Alkenylation Strategy

Organic letters, 2016-11, Vol.18 (21), p.5724-5727

2016

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Ni-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and Optimization

Journal of the American Chemical Society, 2015-06, Vol.137 (22), p.7019-7022

2015

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Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

Chemistry : a European journal, 2022-12, Vol.28 (67), p.e202202164-n/a

2022

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A divergent intermediate strategy yields biologically diverse pseudo-natural products

Nature chemistry, 2024-06, Vol.16 (6), p.945

2024

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A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway

Chemical science (Cambridge), 2023-07, Vol.14 (29), p.7936-7943

2023

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Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space

Angewandte Chemie International Edition, 2023-11, Vol.62 (48), p.e202310222-n/a

International ed. in English, 2023

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Collective Synthesis of Sarpagine and Macroline Alkaloid‐Inspired Compounds

Chemistry : a European journal, 2024-01, Vol.30 (5), p.e202303027-n/a

2024

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Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions

Organic letters, 2014-08, Vol.16 (15), p.3970-3973

2014

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Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay

Chembiochem : a European journal of chemical biology, 2022-11, Vol.23 (22), p.e202200475-n/a

2022

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Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

Chembiochem : a European journal of chemical biology, 2023-12, Vol.24 (24), p.e202300579-n/a

2023

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The Time and Place for Nature in Drug Discovery

JACS Au, 2022-11, Vol.2 (11), p.2400-2416

2022

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Single-Flask Multicomponent Palladium-Catalyzed [alpha],[gamma]-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds

Angewandte Chemie International Edition, 2015-09, Vol.54 (40), p.11822

International ed. in English, 2015

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A nickel-catalyzed α,β-coupling of saturated ketones

Tetrahedron letters, 2015-06, Vol.56 (23), p.3468-3472

2015

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Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic

Journal of organic chemistry, 2021-01, Vol.86 (2), p.1612-1621

2021

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The Pseudo‐Natural Product Rhonin Targets RHOGDI

Angewandte Chemie International Edition, 2022-04, Vol.61 (18), p.e202115193-n/a

International ed. in English, 2022

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Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery

Natural product fragment combination to performance-diverse pseudo-natural products

Dynamic Catalytic Highly Enantioselective 1,3‐Dipolar Cycloadditions

Chemical Evolution of Natural Product Structure

Synthesis of Indofulvin Pseudo‐Natural Products Yields a New Autophagy Inhibitor Chemotype

Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling

Spacial ScoreA Comprehensive Topological Indicator for Small-Molecule Complexity

Dynamic Catalytic Highly Enantioselective 1,3‐Dipolar Cycloadditions

Progress and opportunities of pseudo-natural-product design in molecular discovery

Phenotypic profiling enables the targeted design of a novel pseudo-natural product class

Single-Flask Multicomponent Synthesis of Highly Substituted α‑Pyrones via a Sequential Enolate Arylation and Alkenylation Strategy

Ni-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions: Catalyst Identification and Optimization

Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone

A divergent intermediate strategy yields biologically diverse pseudo-natural products

A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway

Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space

Collective Synthesis of Sarpagine and Macroline Alkaloid‐Inspired Compounds

Palladium-Catalyzed Alkenylation of Ketone Enolates under Mild Conditions

Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay

Inducin Triggers LC3‐Lipidation and ESCRT‐Mediated Lysosomal Membrane Repair

The Time and Place for Nature in Drug Discovery

Single-Flask Multicomponent Palladium-Catalyzed [alpha],[gamma]-Coupling of Ketone Enolates: Facile Preparation of Complex Carbon Scaffolds

A nickel-catalyzed α,β-coupling of saturated ketones

Design, Synthesis, and Evaluation of a Luminescent Cholesterol Mimic

The Pseudo‐Natural Product Rhonin Targets RHOGDI

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