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A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)

Thrombosis and haemostasis, 2009-01, Vol.101 (1), p.68-76

2009

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Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y12 -receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)

The American heart journal, 2010-07, Vol.160 (1), p.65-72

2010

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Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

British journal of clinical pharmacology, 2019-06, Vol.85 (6), p.1290-1302

2019

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Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: The Early Rapid ReversAl of Platelet ThromboSis with Intravenous Elinogrel before PCI to Optimize REperfusion in Acute Myocardial Infarction (ERASE MI) pilot trial

The American heart journal, 2009-12, Vol.158 (6), p.998-1004.e1

2009

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A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Blood, 2019-04, Vol.133 (17), p.1865-1875

2019

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Drug-Drug Interaction Potential of Mavacamten With Oral Contraceptives: Results From a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic Model

Journal of clinical pharmacology, 2023-11, Vol.63 (11), p.1275-1282

2023

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Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)

European heart journal, 2013-05, Vol.34 (20), p.1498-1505

2013

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Platelet Glycoprotein IIb-IIIa Antagonists as Prototypical Integrin Blockers: Novel Parenteral and Potential Oral Antithrombotic Agents

Journal of medicinal chemistry, 2000-09, Vol.43 (19), p.3453-3473

2000

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Effects of Omeprazole and Verapamil on the Pharmacokinetics, Safety, and Tolerability of Mavacamten: Two Drug–Drug Interaction Studies in Healthy Participants

Clinical pharmacology in drug development, 2023-12, Vol.12 (12), p.1241-1251

2023

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Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients

The American heart journal, 2010-04, Vol.159 (4), p.508-517.e1

2010

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Characterization of mavacamten pharmacokinetics in patients with hypertrophic cardiomyopathy to inform dose titration

CPT: pharmacometrics and systems pharmacology, 2024-08

2024

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Recommendation of mavacamten posology by model-based analyses in adults with obstructive hypertrophic cardiomyopathy

CPT: pharmacometrics and systems pharmacology, 2024-05

2024

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The Kinetics of Integrilin Limited by Obesity: A multicenter randomized pharmacokinetic and pharmacodynamic clinical trial

The American heart journal, 2011-12, Vol.162 (6), p.996-1002

2011

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PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers

Journal of clinical pharmacology, 2017-02, Vol.57 (2), p.194-210

2017

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Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)

The American heart journal, 2010-07, Vol.160 (1), p.65-72

2010

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ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY

Journal of the American College of Cardiology, 2013-03, Vol.61 (10), p.E271-E271

2013

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Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

Expert opinion on pharmacotherapy, 2013-01, Vol.14 (1), p.5-13

2013

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Pharmacokinetic and pharmacodynamic properties of eptifibatide in healthy subjects receiving unfractionated heparin or the low-molecular-weight heparin enoxaparin

Clinical therapeutics, 2003-10, Vol.25 (10), p.2564-2574

GRETLER, Daniel D

2003

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Pharmacokinetic and pharmacodynamic properties of eptifibatide in subjects with normal or impaired renal function

Clinical therapeutics, 2004, Vol.26 (3), p.390-398

2004

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KINETICS OF INTEGRILIN LIMITED BY OBESITY (KILO): A MULTI-CENTER RANDOMIZED CLINICAL TRIAL

Journal of the American College of Cardiology, 2011-04, Vol.57 (14), p.E1148-E1148

2011

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Platelet functions beyond hemostasis

Journal of thrombosis and haemostasis, 2009-11, Vol.7 (11), p.1759-1766

2009

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Pharmacokinetic and pharmacodynamic properties of eptifabatide in healthy subjects receiving unfractionated heparin or the low-molecular-weight heparin enoxaparin

Clinical therapeutics, 2003-10, Vol.25 (10), p.2564-2574

Gretler, Daniel D.

2003

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A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y 12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention: The INNOVATE-PCI Trial

Circulation. Cardiovascular interventions, 2012-06, Vol.5 (3), p.336-346

2012

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Enoxaparin versus heparin in patients receiving eptifibatide

Journal of the American College of Cardiology, 2002-03, Vol.39, p.234-234

2002

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Single ascending dose escalation study of the specific Syk inhibitor P505-15 investigating pharmacokinetics, pharmacodynamics, and safety in healthy male volunteers

Journal of clinical oncology, 2013-05, Vol.31 (15_suppl), p.8574-8574

2013

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A randomized evaluation of betrixaban, an oral factor Xa inhibitor, for prevention of thromboembolic events after total knee replacement (EXPERT)

Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y12 -receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease

Drug-Drug Interaction Potential of Mavacamten With Oral Contraceptives: Results From a Clinical Pharmacokinetic Study and a Physiologically Based Pharmacokinetic Model

Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)

Platelet Glycoprotein IIb-IIIa Antagonists as Prototypical Integrin Blockers: Novel Parenteral and Potential Oral Antithrombotic Agents

Effects of Omeprazole and Verapamil on the Pharmacokinetics, Safety, and Tolerability of Mavacamten: Two Drug–Drug Interaction Studies in Healthy Participants

Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients

Characterization of mavacamten pharmacokinetics in patients with hypertrophic cardiomyopathy to inform dose titration

Recommendation of mavacamten posology by model-based analyses in adults with obstructive hypertrophic cardiomyopathy

The Kinetics of Integrilin Limited by Obesity: A multicenter randomized pharmacokinetic and pharmacodynamic clinical trial

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers

ABSENCE OF QTC PROLONGATION WITH BETRIXABAN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO- AND POSITIVE-CONTROLLED THOROUGH ECG STUDY

Absence of QTc prolongation with betrixaban: a randomized, double-blind, placebo- and positive-controlled thorough ECG study

Pharmacokinetic and pharmacodynamic properties of eptifibatide in healthy subjects receiving unfractionated heparin or the low-molecular-weight heparin enoxaparin

Pharmacokinetic and pharmacodynamic properties of eptifibatide in subjects with normal or impaired renal function

KINETICS OF INTEGRILIN LIMITED BY OBESITY (KILO): A MULTI-CENTER RANDOMIZED CLINICAL TRIAL

Platelet functions beyond hemostasis

Pharmacokinetic and pharmacodynamic properties of eptifabatide in healthy subjects receiving unfractionated heparin or the low-molecular-weight heparin enoxaparin

A Randomized, Double-Blind, Active-Controlled Phase 2 Trial to Evaluate a Novel Selective and Reversible Intravenous and Oral P2Y 12 Inhibitor Elinogrel Versus Clopidogrel in Patients Undergoing Nonurgent Percutaneous Coronary Intervention: The INNOVATE-PCI Trial

Enoxaparin versus heparin in patients receiving eptifibatide

Single ascending dose escalation study of the specific Syk inhibitor P505-15 investigating pharmacokinetics, pharmacodynamics, and safety in healthy male volunteers

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