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Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale

Organic process research & development, 2019-11, Vol.23 (11), p.2532-2537

2019

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Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

Angewandte Chemie (International ed.), 2009-01, Vol.48 (20), p.3689-3691

2009

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Asymmetric Synthesis of Dihydroindanes by Convergent Alkoxide-Directed Metallacycle-Mediated Bond Formation

Journal of the American Chemical Society, 2012-02, Vol.134 (5), p.2766-2774

2012

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Formal Synthesis of Leustroducsin B via Reformatsky/Claisen Condensation of Silyl Glyoxylates

Organic letters, 2011-06, Vol.13 (12), p.3206-3209

2011

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Enabling Asymmetric Synthesis of ABBV-3748, a Corrector Compound for the Treatment of Cystic Fibrosis

Organic letters, 2022-10, Vol.24 (40), p.7305-7308

2022

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Catalytic Redox-Initiated Glycolate Aldol Additions of Silyl Glyoxylates

Organic letters, 2009-02, Vol.11 (4), p.827-830

2009

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Enabling Synthesis of ABBV-2222, A CFTR Corrector for the Treatment of Cystic Fibrosis

Organic letters, 2019-07, Vol.21 (14), p.5725-5727

2019

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General Asymmetric Synthesis of Densely Functionalized Pyrrolidines via Endo -Selective [3+2] Cycloaddition of β-Quaternary-Substituted Nitroalkenes and Azomethine Ylides

Journal of organic chemistry, 2020-06, Vol.85 (11), p.7620-7632

2020

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Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α‑Arylation of Reformatsky Reagents

Organic letters, 2017-05, Vol.19 (10), p.2490-2493

2017

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Fueling the Pipeline via Innovations in Organic Synthesis

ACS medicinal chemistry letters, 2021-09, Vol.12 (9), p.1365-1373

2021

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Synthesis of the Cortistatin Pentacyclic Core by Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling

Organic letters, 2016-06, Vol.18 (11), p.2624-2627

2016

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Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives

Journal of organic chemistry, 2022-01, Vol.87 (1), p.776-789

2022

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Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11034-11044

2020

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Remote Stereoinduction in the Acylation of Fully Substituted Enolates: Tandem Reformatsky/Quaternary Claisen Condensations of Silyl Glyoxylates and β-Lactones

Journal of the American Chemical Society, 2010-12, Vol.132 (49), p.17393-17395

2010

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Desymmetrization of pibrentasvir for efficient prodrug synthesis

Chemical science (Cambridge), 2021-07, Vol.12 (29), p.176-182

2021

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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6456-6494

2024

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Synthesis of ABBV-168, a 2′-Bromouridine for the Treatment of Hepatitis C

Journal of organic chemistry, 2019-04, Vol.84 (8), p.4723-4734

2019

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Synthesis of A‑9758, an Inverse Agonist of Retinoic Acid-Related Orphan Receptor γt

ACS omega, 2022-12, Vol.7 (48), p.44383-44389

2022

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Silyl Glyoxylates. Conception and Realization of Flexible Conjunctive Reagents for Multicomponent Coupling

Journal of organic chemistry, 2012-05, Vol.77 (10), p.4503-4515

2012

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Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone

Organic process research & development, 2024-07

2024

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Diastereoselective Synthesis of Pentasubstituted γ‐Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

Angewandte Chemie, 2009-05, Vol.121 (20), p.3743-3745

2009

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ChemInform Abstract: Asymmetric Synthesis of Dihydroindans by Convergent Alkoxide-Directed Metallacycle-Mediated Bond Formation

ChemInform, 2012-08, Vol.43 (33), p.no-no

2012

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Diastereoselective Synthesis of Pentasubstituted γ‐Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

Angewandte Chemie, 2009-05, Vol.121 (20), p.3743-3745

2009

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ChemInform Abstract: Silyl Glyoxylates. Conception and Realization of Flexible Conjunctive Reagents for Multicomponent Coupling

ChemInform, 2012-07, Vol.43 (29), p.no-no

2012

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ChemInform Abstract: Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones Through a Double Reformatsky Reaction

ChemInform, 2009-09, Vol.40 (36), p.no-no

2009

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Development of an Enantioselective [3 + 2] Cycloaddition To Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale

Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

Asymmetric Synthesis of Dihydroindanes by Convergent Alkoxide-Directed Metallacycle-Mediated Bond Formation

Formal Synthesis of Leustroducsin B via Reformatsky/Claisen Condensation of Silyl Glyoxylates

Enabling Asymmetric Synthesis of ABBV-3748, a Corrector Compound for the Treatment of Cystic Fibrosis

Catalytic Redox-Initiated Glycolate Aldol Additions of Silyl Glyoxylates

Enabling Synthesis of ABBV-2222, A CFTR Corrector for the Treatment of Cystic Fibrosis

General Asymmetric Synthesis of Densely Functionalized Pyrrolidines via Endo -Selective [3+2] Cycloaddition of β-Quaternary-Substituted Nitroalkenes and Azomethine Ylides

Synthesis of Substituted Cyclopropanecarboxylates via Room Temperature Palladium-Catalyzed α‑Arylation of Reformatsky Reagents

Fueling the Pipeline via Innovations in Organic Synthesis

Synthesis of the Cortistatin Pentacyclic Core by Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling

Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives

Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530)

Remote Stereoinduction in the Acylation of Fully Substituted Enolates: Tandem Reformatsky/Quaternary Claisen Condensations of Silyl Glyoxylates and β-Lactones

Desymmetrization of pibrentasvir for efficient prodrug synthesis

Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

Synthesis of ABBV-168, a 2′-Bromouridine for the Treatment of Hepatitis C

Synthesis of A‑9758, an Inverse Agonist of Retinoic Acid-Related Orphan Receptor γt

Silyl Glyoxylates. Conception and Realization of Flexible Conjunctive Reagents for Multicomponent Coupling

Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone

Diastereoselective Synthesis of Pentasubstituted γ‐Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

ChemInform Abstract: Asymmetric Synthesis of Dihydroindans by Convergent Alkoxide-Directed Metallacycle-Mediated Bond Formation

Diastereoselective Synthesis of Pentasubstituted γ‐Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction

ChemInform Abstract: Silyl Glyoxylates. Conception and Realization of Flexible Conjunctive Reagents for Multicomponent Coupling

ChemInform Abstract: Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones Through a Double Reformatsky Reaction

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