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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.5049-5062

2019

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Establishing Provenance from Highly Impoverished Heavy Mineral Suites: Detrital Apatite and Zircon Geochronology of Central North Sea Triassic Sandstones

Geosciences (Basel), 2023-01, Vol.13 (1), p.13

2023

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A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects

Neuropsychopharmacology (New York, N.Y.), 2015-12, Vol.40 (13), p.2948-2959

2015

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Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

The Journal of biological chemistry, 2012-01, Vol.287 (1), p.91-104

2012

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Motor-like Tics are Mediated by CB2 Cannabinoid Receptor-dependent and Independent Mechanisms Associated with Age and Sex

Molecular neurobiology, 2022-08, Vol.59 (8), p.5070-5083

2022

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Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

Nature medicine, 2005-07, Vol.11 (7), p.774-779

2005

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CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity

Molecules (Basel, Switzerland), 2024-04, Vol.29 (8), p.1881

2024

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Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids

Cell communication and signaling, 2019-05, Vol.17 (1), p.40-40, Article 40

2019

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Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis

Science advances, 2023-12, Vol.9 (49), p.eadj6187-eadj6187

2023

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Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (18), p.4403-4407

2016

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Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3

Psychopharmacology, 2022, Vol.239 (1), p.253-266

2022

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The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2

Experimental physiology, 2024-01, Vol.109 (1), p.81-99

2024

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Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro

Calcified tissue international, 2008-03, Vol.82 (3), p.191-201

2008

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A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models

Neuropsychopharmacology (New York, N.Y.), 2021-01, Vol.46 (2), p.413-422

2021

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Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2780-2789

2017

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Synthesis and structure-activity relationship studies of novel tubulysin U analogues--effect on cytotoxicity of structural variations in the tubuvaline fragment

Organic & biomolecular chemistry, 2013-04, Vol.11 (14), p.2273-2287

2013

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In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

Behavioural pharmacology, 2014-04, Vol.25 (2), p.182

2014

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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB 1 Receptor Positive Allosteric Modulators

Journal of medicinal chemistry, 2019-05, Vol.62 (10), p.5049-5062

2019

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In Vitro Characterization of 6‑Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl‑1H‑indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?

ACS pharmacology & translational science, 2022-12, Vol.5 (12), p.1279-1291

2022

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Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice

Annals of the rheumatic diseases, 2015-01, Vol.74 (1), p.220-226

2015

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In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1 H -indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?

ACS pharmacology & translational science, 2022-12, Vol.5 (12), p.1279-1291

2022

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Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

Behavioural pharmacology, 2015-04, Vol.26 (3), p.289

2015

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Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

ACS infectious diseases, 2018-07, Vol.4 (7), p.1130-1145

2018

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Development of triarylsulfonamides as novel anti-inflammatory agents

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.816-820

2013

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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators

Establishing Provenance from Highly Impoverished Heavy Mineral Suites: Detrital Apatite and Zircon Geochronology of Central North Sea Triassic Sandstones

A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects

Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids

Motor-like Tics are Mediated by CB2 Cannabinoid Receptor-dependent and Independent Mechanisms Associated with Age and Sex

Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors

CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity

Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids

Small-molecule targeting AMPA-mediated excitotoxicity has therapeutic effects in mouse models for multiple sclerosis

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3

The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2

Aminobisphosphonates Cause Osteoblast Apoptosis and Inhibit Bone Nodule Formation In Vitro

A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models

Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy

Synthesis and structure-activity relationship studies of novel tubulysin U analogues--effect on cytotoxicity of structural variations in the tubuvaline fragment

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB 1 Receptor Positive Allosteric Modulators

In Vitro Characterization of 6‑Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl‑1H‑indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?

Identification of small molecule inhibitors of RANKL and TNF signalling as anti-inflammatory and antiresorptive agents in mice

In Vitro Characterization of 6-Methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1 H -indole (ZCZ011) at the Type 1 Cannabinoid Receptor: Allosteric Agonist or Allosteric Modulator?

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism

Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics

Development of triarylsulfonamides as novel anti-inflammatory agents

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