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Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology

PLoS computational biology, 2021-07, Vol.17 (7), p.e1009135

2021

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Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study

International Journal of Obesity, 2018-07, Vol.42 (7), p.1285-1295

2018

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High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLoS genetics, 2021-08, Vol.17 (8), p.e1009732

2021

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The neurological toxicity of heavy metals: A fish perspective

Comparative biochemistry and physiology. Toxicology & pharmacology, 2018-06, Vol.208, p.12-19

2018

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LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

Scientific reports, 2022-06, Vol.12 (1), p.9104-9104, Article 9104

2022

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MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

Pharmaceuticals (Basel, Switzerland), 2023-05, Vol.16 (5), p.757

2023

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RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

Pharmaceuticals (Basel, Switzerland), 2023-05, Vol.16 (5), p.726

2023

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Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

Cells (Basel, Switzerland), 2023-06, Vol.12 (12), p.1574

2023

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Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework

Education sciences, 2021-03, Vol.11 (3), p.109

2021

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Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

PLoS computational biology, 2024-09, Vol.20 (9), p.e1012423

2024

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Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function

Neurotoxicology (Park Forest South), 2023-05, Vol.96, p.129-139

2023

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The Effects of Long-term, Low-dose β-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Neurotoxicity research, 2023-10, Vol.41 (5), p.481-495

2023

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Extending the lymphoblastoid cell line model for drug combination pharmacogenomics

Pharmacogenomics, 2021-06, Vol.22 (9), p.543-551

2021

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Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Neurotoxicity research, 2023-10, Vol.41 (5), p.496-496

2023

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Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats

Reproductive toxicology (Elmsford, N.Y.), 2017-03, Vol.68, p.119-129

2017

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An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances

Toxicological sciences, 2024-09

2024

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THE NEURODEVELOPMENTAL TOXICITY OF HEAVY METALS: A FISH PERSPECTIVE

Comparative biochemistry and physiology. Toxicology & pharmacology, 2017-12, Vol.208, p.12-19

2017

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IMKX-AS1/I Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

Pharmaceuticals (Basel, Switzerland), 2023-05, Vol.16 (5)

2023

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IRYK/I Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

Pharmaceuticals (Basel, Switzerland), 2023-05, Vol.16 (5)

2023

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The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD G93R Transgenic Zebrafish

Neurotoxicity research, 2023-10, Vol.41 (5), p.481

2023

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Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD G93R Transgenic Zebrafish

Neurotoxicity research, 2023-10, Vol.41 (5), p.496

2023

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Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial

EBioMedicine, 2022-11, Vol.85, p.104298, Article 104298

2022

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Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory

BMC medical research methodology, 2017-09, Vol.17 (1), p.144-144, Article 144

2017

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Changes in health in England, with analysis by English regions and areas of deprivation, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

The Lancet (British edition), 2015-12, Vol.386 (10010), p.2257-2274

2015

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Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology

Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

The neurological toxicity of heavy metals: A fish perspective

LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function

The Effects of Long-term, Low-dose β-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Extending the lymphoblastoid cell line model for drug combination pharmacogenomics

Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats

An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances

THE NEURODEVELOPMENTAL TOXICITY OF HEAVY METALS: A FISH PERSPECTIVE

IMKX-AS1/I Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

IRYK/I Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD G93R Transgenic Zebrafish

Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SOD G93R Transgenic Zebrafish

Tolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine: An open-label partially-randomised ascending dose phase I trial

2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure

Pragmatic clinical trials embedded in healthcare systems: generalizable lessons from the NIH Collaboratory

Changes in health in England, with analysis by English regions and areas of deprivation, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

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