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Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin

Circulation (New York, N.Y.), 2015-04, Vol.131 (14), p.1247-1259

2015

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Catch a Tiny Fish by the Tail

Biophysical journal, 2020-08, Vol.119 (4), p.721-723

Granzier, Henk L.

2020

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Pharmacological Inhibition of Myostatin in a Mouse Model of Typical Nemaline Myopathy Increases Muscle Size and Force

International journal of molecular sciences, 2023-10, Vol.24 (20), p.15124

2023

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Tuning the molecular giant titin through phosphorylation: Role in health and disease

Trends in cardiovascular medicine, 2013-07, Vol.23 (5), p.165-171

2013

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Cardiac Titin and Heart Disease

Journal of cardiovascular pharmacology, 2014-03, Vol.63 (3), p.207-212

2014

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Titin Is a Major Human Disease Gene

Circulation (New York, N.Y.), 2013-02, Vol.127 (8), p.938-944

2013

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Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Circulation (New York, N.Y.), 2019-04, Vol.139 (15), p.1813-1827

2019

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Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Science translational medicine, 2018-02, Vol.10 (427)

2018

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Softening the Stressed Giant Titin in Diabetes Mellitus

Circulation research, 2018-07, Vol.123 (3), p.315-317

2018

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The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease

Circulation research, 2004-02, Vol.94 (3), p.284-295

2004

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The giant protein titin regulates the length of the striated muscle thick filament

Nature communications, 2017-10, Vol.8 (1), p.1041-11, Article 1041

2017

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Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations

Progress in biophysics and molecular biology, 2012-10, Vol.110 (2-3), p.204-217

2012

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Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice

Archives of biochemistry and biophysics, 2014-06, Vol.552-553, p.100-107

2014

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Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

The Journal of general physiology, 2019-01, Vol.151 (1), p.42-52

2019

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Reply to Tskhovrebova et al: Titin’s IA junction does not control thick filament length

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (11), p.E1173-E1173

Granzier, Henk L.

2015

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Toward an understanding of myofibrillar function in health and disease

The Journal of general physiology, 2021-03, Vol.153 (3), p.1

2021

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Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

eLife, 2018-12, Vol.7

2018

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HDAC6 modulates myofibril stiffness and diastolic function of the heart

The Journal of clinical investigation, 2022-05, Vol.132 (10), p.1-13

2022

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Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension

Circulation (New York, N.Y.), 2013-10, Vol.128 (18), p.2016-2025

2013

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Diaphragm contractile weakness due to reduced mechanical loading: role of titin

American Journal of Physiology: Cell Physiology, 2019-08, Vol.317 (2), p.C167-C176

2019

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Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells

Muscle & nerve, 2007-12, Vol.36 (6), p.740-755

2007

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Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (44), p.13573-13578

2015

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Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle

Journal of molecular and cellular cardiology, 2011-04, Vol.50 (4), p.731-739

2011

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Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

Journal of the American College of Cardiology, 2019-06, Vol.73 (21), p.2705-2718

2019

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Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin

Catch a Tiny Fish by the Tail

Pharmacological Inhibition of Myostatin in a Mouse Model of Typical Nemaline Myopathy Increases Muscle Size and Force

Tuning the molecular giant titin through phosphorylation: Role in health and disease

Cardiac Titin and Heart Disease

Titin Is a Major Human Disease Gene

Deleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Softening the Stressed Giant Titin in Diabetes Mellitus

The Giant Protein Titin: A Major Player in Myocardial Mechanics, Signaling, and Disease

The giant protein titin regulates the length of the striated muscle thick filament

Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations

Effect of exercise training on post-translational and post-transcriptional regulation of titin stiffness in striated muscle of wild type and IG KO mice

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance

Reply to Tskhovrebova et al: Titin’s IA junction does not control thick filament length

Toward an understanding of myofibrillar function in health and disease

Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy

HDAC6 modulates myofibril stiffness and diastolic function of the heart

Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension

Diaphragm contractile weakness due to reduced mechanical loading: role of titin

Structure-function relations of the giant elastic protein titin in striated and smooth muscle cells

Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

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