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Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes

Drug metabolism and disposition, 1999-04, Vol.27 (4), p.533

1999

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The CYP2D6 Humanized Mouse: Effect of the Human CYP2D6 Transgene and HNF4α on the Disposition of Debrisoquine in the Mouse

Molecular pharmacology, 2001-12, Vol.60 (6), p.1260-1267

2001

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Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model

Cancer research (Chicago, Ill.), 1994-08, Vol.54 (16), p.4393-4397

1994

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Ifosfamide stereoselective dichloroethylation and neurotoxicity

The Lancet (British edition), 1994-04, Vol.343 (8903), p.982-983

1994

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Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites

Life sciences (1973), 2000-11, Vol.68 (1), p.109-117

2000

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Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers

Cancer chemotherapy and pharmacology, 1997, Vol.40 (6), p.531-533

1997

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The N-dechloroethylation of ifosfamide : using stereochemistry the obtain an accurate picture of a clinically relevant metabolic pathway

Cancer chemotherapy and pharmacology, 1996, Vol.37 (4), p.332-336

1996

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Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice

Toxicology letters, 1994-02, Vol.70 (3), p.263-267

1994

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Influence of phenobarbital induction on the enantioselective N-dechloroethylation of ifosfamide enantiomers in the rat

Drug metabolism and disposition, 1994-01, Vol.22 (1), p.165

1994

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Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients

Cancer chemotherapy and pharmacology, 1996, Vol.37 (5), p.451-456

1996

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Stereoselective separations of chiral anticancer drugs and their application to pharmacodynamic and pharmacokinetic studies

Therapeutic drug monitoring, 1993-12, Vol.15 (6), p.570-575

1993

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Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam

Drug metabolism and disposition, 2003-05, Vol.31 (5), p.548-558

2003

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Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients

Chirality (New York, N.Y.), 1999, Vol.11 (4), p.301-308

1999

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4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine

The Journal of pharmacology and experimental therapeutics, 2002-06, Vol.301 (3), p.1025-1032

2002

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The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine

The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.539-546

2003

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Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorus-selective detector

Journal of chromatography. B, Biomedical sciences and applications, 1999-09, Vol.732 (1), p.3-15

1999

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The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse

Molecular pharmacology, 2001-12, Vol.60 (6), p.1260

2001

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Using chirality as a unique probe of pharmacological properties

Journal of Chromatography A, 1995-03, Vol.694 (1), p.169-179

1995

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Plasma exposure of imatinib and its correlation with clinical response in the Tyrosine Kinase Inhibitor Optimization and Selectivity Trial

Haematologica (Roma), 2012-05, Vol.97 (5), p.731-738

2012

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A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

Clinical cancer research, 2014-04, Vol.20 (7), p.1900-1909

2014

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Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography–tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-05, Vol.867 (1), p.105-110

2008

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PI3K inhibition and modulation of immune and tumor microenvironment markers by copanlisib in patients with non-Hodgkin's lymphoma or advanced solid tumors

Annals of oncology, 2018-10, Vol.29, p.viii20-viii20

2018

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67PPI3K inhibition and modulation of immune and tumor microenvironment markers by copanlisib in patients with non-Hodgkin's lymphoma or advanced solid tumors

Annals of oncology, 2018-10, Vol.29 (suppl_8)

2018

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SAFETY RUN‐IN OF COPANLISIB IN COMBINATION WITH RITUXIMAB PLUS BENDAMUSTINE IN PATIENTS WITH RELAPSED INDOLENT NON‐HODGKIN'S LYMPHOMA

Hematological oncology, 2017-06, Vol.35 (S2), p.408-410

2017

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SAFETY RUN‐IN OF COPANLISIB IN COMBINATION WITH RITUXIMAB PLUS BENDAMUSTINE IN PATIENTS WITH RELAPSED INDOLENT NON‐HODGKIN'S LYMPHOMA

Hematological oncology, 2017-06, Vol.35, p.408-410

2017

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Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes

The CYP2D6 Humanized Mouse: Effect of the Human CYP2D6 Transgene and HNF4α on the Disposition of Debrisoquine in the Mouse

Efficacy and toxicity of ifosfamide stereoisomers in an in vivo rat mammary carcinoma model

Ifosfamide stereoselective dichloroethylation and neurotoxicity

Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites

Phenytoin-induced alteration in the N-dechloroethylation of ifosfamide stereoisomers

The N-dechloroethylation of ifosfamide : using stereochemistry the obtain an accurate picture of a clinically relevant metabolic pathway

Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice

Influence of phenobarbital induction on the enantioselective N-dechloroethylation of ifosfamide enantiomers in the rat

Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients

Stereoselective separations of chiral anticancer drugs and their application to pharmacodynamic and pharmacokinetic studies

Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam

Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients

4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine

The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine

Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorus-selective detector

The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse

Using chirality as a unique probe of pharmacological properties

Plasma exposure of imatinib and its correlation with clinical response in the Tyrosine Kinase Inhibitor Optimization and Selectivity Trial

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography–tandem mass spectrometry

PI3K inhibition and modulation of immune and tumor microenvironment markers by copanlisib in patients with non-Hodgkin's lymphoma or advanced solid tumors

67PPI3K inhibition and modulation of immune and tumor microenvironment markers by copanlisib in patients with non-Hodgkin's lymphoma or advanced solid tumors

SAFETY RUN‐IN OF COPANLISIB IN COMBINATION WITH RITUXIMAB PLUS BENDAMUSTINE IN PATIENTS WITH RELAPSED INDOLENT NON‐HODGKIN'S LYMPHOMA

SAFETY RUN‐IN OF COPANLISIB IN COMBINATION WITH RITUXIMAB PLUS BENDAMUSTINE IN PATIENTS WITH RELAPSED INDOLENT NON‐HODGKIN'S LYMPHOMA

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