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The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7159-7163

2010

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The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7155-7158

2010

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N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration

Journal of medicinal chemistry, 2000-05, Vol.43 (9), p.1661-1663

2000

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Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5712-5719

2007

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4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.775-777

2000

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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Journal of medicinal chemistry, 1997-04, Vol.40 (9), p.1347-1365

1997

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CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain

European journal of pharmacology, 2009-09, Vol.617 (1), p.59-67

2009

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Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (8), p.1171-1174

1999

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Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (8), p.1167-1170

1999

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Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

Bioorganic & medicinal chemistry letters, 1996-12, Vol.6 (23), p.2827-2830

1996

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Radiosynthesis, in vitro validation, and in vivo evaluation of (18)F-laveled COX-1 and COX-2 inhibitors

The Journal of nuclear medicine (1978), 2002-01, Vol.43 (1), p.117

2002

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Radiosynthesis, In Vitro Validation, and In Vivo Evaluation of 18F-Labeled COX-1 and COX-2 Inhibitors

The Journal of nuclear medicine (1978), 2002-01, Vol.43 (1), p.117-124

2002

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3,4-diarylthiophenes are selective COX-2 inhibitors

Bioorganic & medicinal chemistry letters, 1995-12, Vol.5 (23), p.2919-2922

1995

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ChemInform Abstract: Design and Synthesis of Sulfonyl-Substituted 4,5-Diarylthiazoles as Selective Cyclooxygenase-2 Inhibitors

ChemInform, 1999-08, Vol.30 (32), p.no-no

1999

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ChemInform Abstract: Synthesis and Activity of Sulfonamide-Substituted 4,5-Diaryl Thiazoles as Selective Cyclooxygenase-2 Inhibitors

ChemInform, 1999-08, Vol.30 (33), p.no-no

1999

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A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

The Journal of biological chemistry, 2003-08, Vol.278 (35), p.32861-32871

2003

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Multivalent sialyl-LeX: potent inhibitors of E-selectin-mediated cell adhesion; reagent for staining activated endothelial cells

Glycobiology (Oxford), 1994-06, Vol.4 (3), p.259-265

1994

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The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life

The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate

N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration

Synthesis, Crystal Structure, and Activity of Pyrazole-Based Inhibitors of p38 Kinase

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

Radiosynthesis, in vitro validation, and in vivo evaluation of (18)F-laveled COX-1 and COX-2 inhibitors

Radiosynthesis, In Vitro Validation, and In Vivo Evaluation of 18F-Labeled COX-1 and COX-2 Inhibitors

3,4-diarylthiophenes are selective COX-2 inhibitors

ChemInform Abstract: Design and Synthesis of Sulfonyl-Substituted 4,5-Diarylthiazoles as Selective Cyclooxygenase-2 Inhibitors

ChemInform Abstract: Synthesis and Activity of Sulfonamide-Substituted 4,5-Diaryl Thiazoles as Selective Cyclooxygenase-2 Inhibitors

A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

Multivalent sialyl-LeX: potent inhibitors of E-selectin-mediated cell adhesion; reagent for staining activated endothelial cells

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