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eIF-4E expression and its role in malignancies and metastases

Oncogene, 2004-04, Vol.23 (18), p.3189-3199

2004

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Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

Cell reports (Cambridge), 2014-12, Vol.9 (5), p.1742-1755

2014

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Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

Cancer research (Chicago, Ill.), 2008-02, Vol.68 (3), p.631-634

2008

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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

The Journal of clinical investigation, 2007-09, Vol.117 (9), p.2638-2648

2007

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Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

Blood, 2013-05, Vol.121 (18), p.3675-3681

2013

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Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Cancer research (Chicago, Ill.), 2011-03, Vol.71 (5), p.1849-1857

2011

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Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

PloS one, 2016-11, Vol.11 (11), p.e0165909-e0165909

2016

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Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies

Frontiers in oncology, 2022-05, Vol.12, p.869078-869078

2022

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Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide

PloS one, 2013-11, Vol.8 (11), p.e81669

2013

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Incidence and Functional Consequences of hMLH1 Promoter Hypermethylation in Colorectal Carcinoma

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (12), p.6870-6875

1998

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Targeting the eIF4F translation initiation complex for cancer therapy

Cell cycle (Georgetown, Tex.), 2008-08, Vol.7 (16), p.2466-2471

2008

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Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis

Clinical cancer research, 2004-05, Vol.10 (10), p.3448-3456

2004

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Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

Advances in Cancer Research, 1997, Vol.72, p.141,182a,182b,183-182,182a,182b,196

1997

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Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis

Molecular cancer therapeutics, 2010-12, Vol.9 (12), p.3158-3163

2010

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Expression of Group IIA Secretory Phospholipase A2 Is Elevated in Prostatic Intraepithelial Neoplasia and Adenocarcinoma

The American journal of pathology, 2002-02, Vol.160 (2), p.667-671

2002

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Expression of Group IIa Secretory Phospholipase A2 Increases with Prostate Tumor Grade

Clinical cancer research, 2001-12, Vol.7 (12), p.3857-3861

2001

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AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon

Clinical cancer research, 2001-08, Vol.7 (8), p.2475-2479

2001

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Integrin-linked Kinase Expression Increases with Prostate Tumor Grade

Clinical cancer research, 2001-07, Vol.7 (7), p.1987-1991

2001

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Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity

Molecular cancer therapeutics, 2014-02, Vol.13 (2), p.364-374

2014

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Int7G24A Variant of Transforming Growth Factor-β Receptor Type I Is Associated with Invasive Breast Cancer

Clinical cancer research, 2006-01, Vol.12 (2), p.392-397

2006

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Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

The Journal of clinical investigation, 2016-06, Vol.126 (6), p.2181-2190

2016

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Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma

British journal of cancer, 2016-02, Vol.114 (4), p.444-453

2016

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The protein kinase Cβ-selective inhibitor, enzastaurin (LY317615.HCI), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

Cancer research (Chicago, Ill.), 2005-08, Vol.65 (16), p.7462-7469

2005

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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

Investigational new drugs, 2013-08, Vol.31 (4), p.833-844

2013

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eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (9), p.3866-3873

2009

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eIF-4E expression and its role in malignancies and metastases

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation

Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies

Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide

Incidence and Functional Consequences of hMLH1 Promoter Hypermethylation in Colorectal Carcinoma

Targeting the eIF4F translation initiation complex for cancer therapy

Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis

Expression of Group IIA Secretory Phospholipase A2 Is Elevated in Prostatic Intraepithelial Neoplasia and Adenocarcinoma

Expression of Group IIa Secretory Phospholipase A2 Increases with Prostate Tumor Grade

AKT-1, -2, and -3 are Expressed in Both Normal and Tumor Tissues of the Lung, Breast, Prostate, and Colon

Integrin-linked Kinase Expression Increases with Prostate Tumor Grade

Characterization of LY2228820 dimesylate, a potent and selective inhibitor of p38 MAPK with antitumor activity

Int7G24A Variant of Transforming Growth Factor-β Receptor Type I Is Associated with Invasive Breast Cancer

Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers

Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma

The protein kinase Cβ-selective inhibitor, enzastaurin (LY317615.HCI), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts

LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

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