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Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Molecules (Basel, Switzerland), 2021-11, Vol.26 (23), p.7165

2021

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Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH

The Journal of biological chemistry, 2013-08, Vol.288 (33), p.24247-24263

2013

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Novel Pathway of Adenosine Generation in the Lungs from NAD + : Relevance to Allergic Airway Disease

Molecules (Basel, Switzerland), 2020-10, Vol.25 (21), p.4966

2020

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Determination of ADP-ribosyl cyclase activity, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in tissue extracts

Methods in molecular biology (Clifton, N.J.), 2013, Vol.1016, p.39

2013

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CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mediators of inflammation, 2018-01, Vol.2018, p.8942042-10

2018

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Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38

The Journal of biological chemistry, 2009-10, Vol.284 (40), p.27629-27636

2009

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Crystal Structure of Human CD38 Extracellular Domain

Structure (London), 2005-09, Vol.13 (9), p.1331-1339

2005

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'Click cyclic ADP-ribose': a neutral second messenger mimic

Chemical communications (Cambridge, England), 2014-01, Vol.50 (19), p.2458-2461

2014

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Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38

Journal of medicinal chemistry, 2014-10, Vol.57 (20), p.8517-8529

2014

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Porcine CD38 exhibits prominent secondary NAD+ cyclase activity

Protein science, 2016-03, Vol.25 (3), p.650-661

2016

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Acidic Residues at the Active Sites of CD38 and ADP-ribosyl Cyclase Determine Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthesis and Hydrolysis Activities

The Journal of biological chemistry, 2006-09, Vol.281 (39), p.28951-28957

2006

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CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template

PloS one, 2013-06, Vol.8 (6), p.e66247-e66247

2013

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Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

The Journal of biological chemistry, 2009-10, Vol.284 (40), p.27637-27645

2009

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Structural Basis for the Mechanistic Understanding of Human CD38-controlled Multiple Catalysis

The Journal of biological chemistry, 2006-10, Vol.281 (43), p.32861-32869

2006

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Roles of cADPR and NAADP in pancreatic cells

Acta biochimica et biophysica Sinica, 2012-09, Vol.44 (9), p.719-729

2012

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Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites

Current biology, 2008-10, Vol.18 (20), p.1612-1618

2008

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Abscisic acid signaling through cyclic ADP-ribose in plants

Science (American Association for the Advancement of Science), 1997-12, Vol.278 (5346), p.2126-2130

1997

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Structural Basis for Formation and Hydrolysis of the Calcium Messenger Cyclic ADP-ribose by Human CD38

The Journal of biological chemistry, 2007-02, Vol.282 (8), p.5853-5861

2007

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Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry

Analytical biochemistry, 2013-02, Vol.433 (2), p.218-226

2013

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Evidence for a Causal Role of CD38 Expression in Granulocytic Differentiation of Human HL-60 Cells

The Journal of biological chemistry, 2002-12, Vol.277 (51), p.49453-49458

2002

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Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

Current biology, 2008-10, Vol.18 (20), p.1612-1618

2008

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Identification of the Enzymatic Active Site of CD38 by Site-directed Mutagenesis

The Journal of biological chemistry, 2000-07, Vol.275 (28), p.21566-21571

2000

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Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway

World journal of biological chemistry, 2014-02, Vol.5 (1), p.58-67

2014

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Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog

The Journal of biological chemistry, 2007-08, Vol.282 (34), p.24825-24832

2007

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ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+(∗)

The Journal of biological chemistry, 1995-12, Vol.270 (51), p.30327-30333

1995

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Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5′-monophosphate, Analogues and Early Structure-Activity Relationship

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH

Novel Pathway of Adenosine Generation in the Lungs from NAD + : Relevance to Allergic Airway Disease

Determination of ADP-ribosyl cyclase activity, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in tissue extracts

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms

Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38

Crystal Structure of Human CD38 Extracellular Domain

'Click cyclic ADP-ribose': a neutral second messenger mimic

Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase–Hydrolase CD38

Porcine CD38 exhibits prominent secondary NAD+ cyclase activity

Acidic Residues at the Active Sites of CD38 and ADP-ribosyl Cyclase Determine Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Synthesis and Hydrolysis Activities

CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template

Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

Structural Basis for the Mechanistic Understanding of Human CD38-controlled Multiple Catalysis

Roles of cADPR and NAADP in pancreatic cells

Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites

Abscisic acid signaling through cyclic ADP-ribose in plants

Structural Basis for Formation and Hydrolysis of the Calcium Messenger Cyclic ADP-ribose by Human CD38

Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry

Evidence for a Causal Role of CD38 Expression in Granulocytic Differentiation of Human HL-60 Cells

Ca2+ Signaling Occurs via Second Messenger Release from Intraorganelle Synthesis Sites

Identification of the Enzymatic Active Site of CD38 by Site-directed Mutagenesis

Roles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+ signaling pathway

Catalysis-associated Conformational Changes Revealed by Human CD38 Complexed with a Non-hydrolyzable Substrate Analog

ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+(∗)

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