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Mechanisms of action of ribavirin against distinct viruses

Reviews in medical virology, 2006-01, Vol.16 (1), p.37-48

2006

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Small molecule splicing modifiers with systemic HTT-lowering activity

Nature communications, 2021-12, Vol.12 (1), p.7299-7299, Article 7299

2021

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines

Virus research, 2021-01, Vol.292, p.198246-198246, Article 198246

2021

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RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence

The Journal of biological chemistry, 2014-10, Vol.289 (43), p.29531-29544

2014

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Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

Journal of Virology, 2012-03, Vol.86 (5), p.2869-2873

2012

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Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia

Frontiers in oncology, 2022-02, Vol.12, p.832816-832816

2022

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Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3250-3261

2013

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Therapeutically targeting RNA viruses via lethal mutagenesis

Future Virology, 2008-11, Vol.3 (6), p.553-566

2008

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Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

Antimicrobial Agents and Chemotherapy, 2008-03, Vol.52 (3), p.971-979

2008

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Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

Journal of Virology, 2007-10, Vol.81 (20), p.11256-11266

2007

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PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally

Antimicrobial agents and chemotherapy, 2016-12, Vol.60 (12), p.7060-7066

2016

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High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

The Journal of biological chemistry, 2011-06, Vol.286 (24), p.21083-21091

2011

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Quasispecies, Error Catastrophe, and the Antiviral Activity of Ribavirin

Virology, 2002-07, Vol.298 (2), p.175-180

2002

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Effects of Introduction of Hydrophobic Group on Ribavirin Base on Mutation Induction and Anti-RNA Viral Activity

Journal of medicinal chemistry, 2008-01, Vol.51 (1), p.159-166

2008

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Synthesis and Antiviral Activity of 5-Substituted Cytidine Analogues: Identification of a Potent Inhibitor of Viral RNA-Dependent RNA Polymerases

Journal of medicinal chemistry, 2006-10, Vol.49 (21), p.6166-6169

2006

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Synthesis of a Universal 5-Nitroindole Ribonucleotide and Incorporation into RNA by a Viral RNA-Dependent RNA Polymerase

Chembiochem : a European journal of chemical biology, 2007-08, Vol.8 (12), p.1359-1362

2007

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Synthesis and Antiviral Evaluation of a Mutagenic and Non-Hydrogen Bonding Ribonucleoside Analogue: 1-β-d-Ribofuranosyl-3-nitropyrrole

Biochemistry (Easton), 2002-07, Vol.41 (29), p.9026-9033

2002

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Challenges for the Development of Ribonucleoside Analogues as Inducers of Error Catastrophe

Antiviral Chemistry and Chemotherapy, 2004, Vol.15 (1), p.1-13

2004

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HIV Type-1 Latency: Targeted Induction of Proviral Reservoirs

Antiviral Chemistry and Chemotherapy, 2009-04, Vol.19 (5), p.177-187

2009

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Lethal Mutagenesis: Exploiting Error‐Prone Replication of Riboviruses for Antiviral Therapy

Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats, 2005, p.203-220

2005

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Evaluation of nucleoside analogs with ambiguous hydrogen-bonding capacity as antiviral lethal mutagens

Graci, Jason D

2007

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Mechanisms of action of ribavirin against distinct viruses

Small molecule splicing modifiers with systemic HTT-lowering activity

The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines

RNA Virus Population Diversity, an Optimum for Maximal Fitness and Virulence

Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia

Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

Therapeutically targeting RNA viruses via lethal mutagenesis

Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues

Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue

PTC725, an NS4B-Targeting Compound, Inhibits a Hepatitis C Virus Genotype 3 Replicon, as Predicted by Genome Sequence Analysis and Determined Experimentally

High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

Quasispecies, Error Catastrophe, and the Antiviral Activity of Ribavirin

Effects of Introduction of Hydrophobic Group on Ribavirin Base on Mutation Induction and Anti-RNA Viral Activity

Synthesis and Antiviral Activity of 5-Substituted Cytidine Analogues: Identification of a Potent Inhibitor of Viral RNA-Dependent RNA Polymerases

Synthesis of a Universal 5-Nitroindole Ribonucleotide and Incorporation into RNA by a Viral RNA-Dependent RNA Polymerase

Synthesis and Antiviral Evaluation of a Mutagenic and Non-Hydrogen Bonding Ribonucleoside Analogue: 1-β-d-Ribofuranosyl-3-nitropyrrole

Challenges for the Development of Ribonucleoside Analogues as Inducers of Error Catastrophe

HIV Type-1 Latency: Targeted Induction of Proviral Reservoirs

Lethal Mutagenesis: Exploiting Error‐Prone Replication of Riboviruses for Antiviral Therapy

Evaluation of nucleoside analogs with ambiguous hydrogen-bonding capacity as antiviral lethal mutagens

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