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Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

Nature communications, 2023-07, Vol.14 (1), p.4573-4573, Article 4573

2023

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UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5297-5311

2020

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Author Correction: NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells

Scientific reports, 2021-06, Vol.11 (1), p.12444-12444, Article 12444

2021

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Author Correction: NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells

Scientific reports, 2021-05, Vol.11 (1), p.10747-10747, Article 10747

2021

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Frizzleds act as dynamic pharmacological entities

Trends in pharmacological sciences (Regular ed.), 2024-05, Vol.45 (5), p.419-429

2024

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A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

International journal of molecular sciences, 2020-11, Vol.21 (22), p.8440

2020

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WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction

Science signaling, 2023-04, Vol.16 (779), p.eabo4974

2023

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Structural basis of frizzled 7 activation and allosteric regulation

Nature communications, 2024-08, Vol.15 (1), p.7422-15, Article 7422

2024

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Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

Cell reports (Cambridge), 2024-02, Vol.43 (2), p.113727-113727, Article 113727

2024

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NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells

Scientific reports, 2020-08, Vol.10 (1), p.13288-13288, Article 13288

2020

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Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

Journal of medicinal chemistry, 2022-01, Vol.65 (2), p.1283-1301

2022

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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11695-11708

2021

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A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors

International journal of molecular sciences, 2020-08, Vol.21 (17), p.6103

2020

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NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model

British journal of pharmacology, 2023, Vol.181 (20), p.3819-3835

2023

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N‑Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants

Journal of medicinal chemistry, 2021-11, Vol.64 (22), p.16746-16769

2021

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Insertion of Nanoluc into the Extracellular Loops as a Complementary Method To Establish BRET-Based Binding Assays for GPCRs

ACS pharmacology & translational science, 2022-11, Vol.5 (11), p.1142-1155

2022

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A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

Nature communications, 2024-09, Vol.15 (1), p.7684-21, Article 7684

2024

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Illuminating Neuropeptide Y Y4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools

ACS pharmacology & translational science, 2024-04, Vol.7 (4), p.1142-1168

2024

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Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors

Cancers, 2022-10, Vol.14 (19), p.4922

2022

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Truth tables for modal logics T and S4, by using three-valued non-deterministic level semantics

Journal of logic and computation, 2022-01, Vol.32 (1), p.129-157

Grätz, Lukas

2022

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Live-cell microscopy or fluorescence anisotropy with budded baculoviruses-which way to go with measuring ligand binding to M4 muscarinic receptors?

Open biology, 2022-06, Vol.12 (6), p.220019-220019

2022

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Analytic Tableaux for Non-deterministic Semantics

Automated Reasoning with Analytic Tableaux and Related Methods, p.38-55

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BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M 2 muscarinic acetylcholine receptors

Biochimica et biophysica acta. Molecular cell research, 2021-03, Vol.1868 (3), p.118930

2021

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Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs

ACS sensors, 2024-08

2024

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A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H 3 Receptor

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11695-11708

2021

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Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations

UR-DEBa242: A Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors

Author Correction: NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells

Author Correction: NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells

Frizzleds act as dynamic pharmacological entities

A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction

Structural basis of frizzled 7 activation and allosteric regulation

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7

NanoBRET binding assay for histamine H2 receptor ligands using live recombinant HEK293T cells

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H3 Receptor

A Split Luciferase Complementation Assay for the Quantification of β-Arrestin2 Recruitment to Dopamine D2-Like Receptors

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model

N‑Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y4 Receptor Ligands Results in Picomolar Binding Constants

Insertion of Nanoluc into the Extracellular Loops as a Complementary Method To Establish BRET-Based Binding Assays for GPCRs

A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

Illuminating Neuropeptide Y Y4 Receptor Binding: Fluorescent Cyclic Peptides with Subnanomolar Binding Affinity as Novel Molecular Tools

Development of a Neurotensin-Derived 68Ga-Labeled PET Ligand with High In Vivo Stability for Imaging of NTS1 Receptor-Expressing Tumors

Truth tables for modal logics T and S4, by using three-valued non-deterministic level semantics

Live-cell microscopy or fluorescence anisotropy with budded baculoviruses-which way to go with measuring ligand binding to M4 muscarinic receptors?

Analytic Tableaux for Non-deterministic Semantics

BRET- and fluorescence anisotropy-based assays for real-time monitoring of ligand binding to M 2 muscarinic acetylcholine receptors

Class-Wide Analysis of Frizzled-Dishevelled Interactions Using BRET Biosensors Reveals Functional Differences among Receptor Paralogs

A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H 3 Receptor

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