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PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

Advances in cancer research, 2019, Vol.144, p.55-93

2019

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PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

Cell cycle (Georgetown, Tex.), 2015-01, Vol.14 (1), p.18-30

2015

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PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates

Gene, 2012-05, Vol.499 (1), p.1-7

2012

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PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

eLife, 2021-10, Vol.10

2021

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Selective control of gene expression by CDK9 in human cells

Journal of cellular physiology, 2010-01, Vol.222 (1), p.200-208

2010

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Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

Oncogene, 1998-12, Vol.17 (25), p.3365-3383

1998

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CDK9 inhibition strategy defines distinct sets of target genes

BMC research notes, 2014-05, Vol.7 (1), p.301-301, Article 301

2014

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Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis

Cancer research (Chicago, Ill.), 2005-11, Vol.65 (22), p.10174-10178

2005

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Downregulation of the Phosphatase Nuclear Targeting Subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines

Cancer biology & therapy, 2008-06, Vol.7 (6), p.842-844

Graña, Xavier

2008

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Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro

STAR protocols, 2023-04, Vol.4 (2), p.102148-102148, Article 102148

2023

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Cyclin T1 Expression Is Regulated by Multiple Signaling Pathways and Mechanisms during Activation of Human Peripheral Blood Lymphocytes

Journal of Immunology, 2005-11, Vol.175 (10), p.6402-6411

2005

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Complex effects of flavopiridol on the expression of primary response genes

Cell division, 2012-03, Vol.7 (1), p.11-11, Article 11

2012

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B55α PP2A Holoenzymes Modulate the Phosphorylation Status of the Retinoblastoma-related Protein p107 and Its Activation

The Journal of biological chemistry, 2010-09, Vol.285 (39), p.29863-29873

2010

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Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle

Journal of cell science, 2019-10, Vol.132 (20)

2019

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Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT

Scientific reports, 2024-09, Vol.14 (1), p.20409-18, Article 20409

2024

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FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs

Nature communications, 2024-07, Vol.15 (1), p.5776-20, Article 5776

2024

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Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase

Prostate cancer and prostatic diseases, 2021-03, Vol.24 (1), p.233-243

2021

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The Ability of Positive Transcription Elongation Factor b To Transactivate Human Immunodeficiency Virus Transcription Depends on a Functional Kinase Domain, Cyclin T1, and Tat

Journal of Virology, 1998-09, Vol.72 (9), p.7154-7159

1998

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Proliferative Suppression by CDK4/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells

Gastroenterology (New York, N.Y. 1943), 2010-05, Vol.138 (5), p.1920-1930.e2

2010

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Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts

The Journal of biological chemistry, 2008-04, Vol.283 (17), p.11280-11292

2008

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Abstract 2532: MicroRNA-1205 directly binds to FRYL and suppresses aggressive prostate cancer

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.2532-2532

2020

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CDK9 Is Constitutively Expressed throughout the Cell Cycle, and Its Steady-State Expression Is Independent of SKP2

Molecular and Cellular Biology, 2003-08, Vol.23 (15), p.5165-5173

2003

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p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts

Cancer research (Chicago, Ill.), 2007-05, Vol.67 (9), p.4130-4137

2007

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4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress

Molecular cancer therapeutics, 2024-05, Vol.23 (5), p.683-699

2024

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PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

PP2A holoenzymes negatively and positively regulate cell cycle progression by dephosphorylating pocket proteins and multiple CDK substrates

PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107

Selective control of gene expression by CDK9 in human cells

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

CDK9 inhibition strategy defines distinct sets of target genes

Cyclin-dependent kinase 4 expression is essential for neu-induced breast tumorigenesis

Downregulation of the Phosphatase Nuclear Targeting Subunit (PNUTS) triggers pRB dephosphorylation and apoptosis in pRB positive tumor cell lines

Protocol to assess substrate dephosphorylation by serine/threonine phosphoprotein phosphatases in vitro

Cyclin T1 Expression Is Regulated by Multiple Signaling Pathways and Mechanisms during Activation of Human Peripheral Blood Lymphocytes

Complex effects of flavopiridol on the expression of primary response genes

B55α PP2A Holoenzymes Modulate the Phosphorylation Status of the Retinoblastoma-related Protein p107 and Its Activation

Invadopodia-mediated ECM degradation is enhanced in the G1 phase of the cell cycle

Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT

FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs

Immortalization of human primary prostate epithelial cells via CRISPR inactivation of the CDKN2A locus and expression of telomerase

The Ability of Positive Transcription Elongation Factor b To Transactivate Human Immunodeficiency Virus Transcription Depends on a Functional Kinase Domain, Cyclin T1, and Tat

Proliferative Suppression by CDK4/6 Inhibition: Complex Function of the Retinoblastoma Pathway in Liver Tissue and Hepatoma Cells

Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts

Abstract 2532: MicroRNA-1205 directly binds to FRYL and suppresses aggressive prostate cancer

CDK9 Is Constitutively Expressed throughout the Cell Cycle, and Its Steady-State Expression Is Independent of SKP2

p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts

4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress

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