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Estimation of Drug-Target Residence Times by τ‑Random Acceleration Molecular Dynamics Simulations

Journal of chemical theory and computation, 2018-07, Vol.14 (7), p.3859-3869

2018

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Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Journal of chemical information and modeling, 2020-11, Vol.60 (11), p.5457-5474

2020

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Identification of M4205A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors

Journal of medicinal chemistry, 2023-02, Vol.66 (4), p.2386-2395

2023

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Fragment-Based Discovery of New Highly Substituted 1H‑Pyrrolo[2,3‑b]- and 3H‑Imidazolo[4,5‑b]‑Pyridines as Focal Adhesion Kinase Inhibitors

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1160-1170

2013

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EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

Clinical cancer research, 2013-06, Vol.19 (11), p.2941-2951

2013

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MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.837-854

2023

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Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors

Journal of medicinal chemistry, 2018-05, Vol.61 (10), p.4397-4411

2018

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Structural and Biophysical Characterization of the Syk Activation Switch

Journal of molecular biology, 2013-01, Vol.425 (2), p.309-333

2013

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Structure-based optimization of non-peptidic Cathepsin D inhibitors

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4141-4150

2014

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Extract2Chip—Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance

Biosensors (Basel), 2023-10, Vol.13 (10), p.913

2023

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Allosteric IGF-1R Inhibitors

ACS medicinal chemistry letters, 2010-08, Vol.1 (5), p.199-203

2010

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Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes

Journal of molecular biology, 2024-03, Vol.436 (6), p.168483, Article 168483

2024

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Corrigendum to “Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors” [Bioorg. Med. Chem. Lett. 30 (2020) 127551]

Bioorganic & medicinal chemistry letters, 2021-10, Vol.49, p.128262-128262, Article 128262

2021

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Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127551-127551, Article 127551

2020

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Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

The Journal of biological chemistry, 2023-11, Vol.299 (11), p.105328, Article 105328

2023

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Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Bioorganic & medicinal chemistry letters, 2019-12, Vol.29 (23), p.126717-126717, Article 126717

2019

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Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1597-1602

2015

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Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes

Journal of molecular biology, 2024-03, Vol.436 (6), p.168483

2024

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Nitric Oxide Synthase Inhibitors into the Clinic at Last

Handbook of experimental pharmacology, 2021, Vol.264, p.169-204

2021

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Discovery of novel 7-azaindoles as PDK1 inhibitors

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3073-3080

2016

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Fragment-based discovery of focal adhesion kinase inhibitors

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5401-5409

2013

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Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (14), p.4228-4232

2011

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Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

Organic & biomolecular chemistry, 2011-07, Vol.9 (14), p.5129-5136

2011

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Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4396-4403

2012

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Fragment-Based Discovery of New Highly Substituted 1 H -Pyrrolo[2,3- b ]- and 3 H -Imidazolo[4,5- b ]-Pyridines as Focal Adhesion Kinase Inhibitors

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1160-1170

2013

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Estimation of Drug-Target Residence Times by τ‑Random Acceleration Molecular Dynamics Simulations

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Identification of M4205A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors

Fragment-Based Discovery of New Highly Substituted 1H‑Pyrrolo[2,3‑b]- and 3H‑Imidazolo[4,5‑b]‑Pyridines as Focal Adhesion Kinase Inhibitors

EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors

Structural and Biophysical Characterization of the Syk Activation Switch

Structure-based optimization of non-peptidic Cathepsin D inhibitors

Extract2Chip—Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance

Allosteric IGF-1R Inhibitors

Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes

Corrigendum to “Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors” [Bioorg. Med. Chem. Lett. 30 (2020) 127551]

Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors

Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors

Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes

Nitric Oxide Synthase Inhibitors into the Clinic at Last

Discovery of novel 7-azaindoles as PDK1 inhibitors

Fragment-based discovery of focal adhesion kinase inhibitors

Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90

Fragment-Based Discovery of New Highly Substituted 1 H -Pyrrolo[2,3- b ]- and 3 H -Imidazolo[4,5- b ]-Pyridines as Focal Adhesion Kinase Inhibitors

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