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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

The Journal of clinical investigation, 2000-06, Vol.105 (11), p.1595-1604

2000

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Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders

Journal of bone and mineral research, 1998-03, Vol.13 (3), p.371-382

1998

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Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (∗)

The Journal of biological chemistry, 1996-05, Vol.271 (21), p.12511-12516

1996

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Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

Journal of bone and mineral research, 2001-10, Vol.16 (10), p.1739-1746

2001

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A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats

The Journal of clinical investigation, 2000-07, Vol.106 (2), p.309-318

2000

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IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase

Journal of cellular physiology, 2001-06, Vol.187 (3), p.294-303

2001

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Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance

The Journal of pharmacology and experimental therapeutics, 2010-12, Vol.335 (3), p.572-579

2010

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Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture

Journal of cell science, 1992-09, Vol.103 (1), p.267-271

1992

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Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption

Journal of bone and mineral research, 2001-03, Vol.16 (3), p.478-486

2001

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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Journal of bone and mineral research, 1997-09, Vol.12 (9), p.1396-1406

1997

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Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2002-07, Vol.302 (1), p.205-211

2002

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Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions

The Journal of biological chemistry, 1999-06, Vol.274 (24), p.17123-17131

1999

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Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro

Journal of orthopaedic research, 2000-05, Vol.18 (3), p.356-363

2000

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Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women

Journal of bone and mineral research, 1990-09, Vol.5 (9), p.983-988

1990

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Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis

The Journal of pharmacology and experimental therapeutics, 1999-11, Vol.291 (2), p.612

1999

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Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro

The Journal of biological chemistry, 2001-04, Vol.276 (15), p.11507-11511

2001

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Cathepsin K mRNA Detection Is Restricted to Osteoclasts During Fetal Mouse Development

Journal of bone and mineral research, 1998-04, Vol.13 (4), p.673-682

1998

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Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.587

1999

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Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis

Technology and health care, 1998-12, Vol.6 (5-6), p.361-372

1998

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Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis

The Journal of pharmacology and experimental therapeutics, 1999-12, Vol.291 (3), p.1380

1999

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Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

Journal of bone and mineral research, 1999-10, Vol.14 (10), p.1654-1663

1999

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First Human Dosing Experience with TRV130, a Biased Ligand at the Mu Opioid Receptor (P02.013)

Neurology, 2013-02, Vol.80 (7_supplement)

2013

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An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation

Bone (New York, N.Y.), 2010-02, Vol.46 (2), p.534-542

2010

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The new partnership of genomics and chemistry for accelerated drug development

Current opinion in chemical biology, 1997-08, Vol.1 (2), p.151-156

1997

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Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.323

2001

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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (∗)

Potent and Selective Inhibition of Human Cathepsin K Leads to Inhibition of Bone Resorption In Vivo in a Nonhuman Primate

A selective inhibitor of the osteoclastic V-H(+)-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats

IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase

Selectively engaging β-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance

Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture

Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption

Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo

Rapid inhibition of thyroxine-induced bone resorption in the rat by an orally active vitronectin receptor antagonist

Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions

Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro

Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women

Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis

Potent and Selective Cathepsin L Inhibitors Do Not Inhibit Human Osteoclast Resorption in Vitro

Cathepsin K mRNA Detection Is Restricted to Osteoclasts During Fetal Mouse Development

Inhibition of interleukin-1-induced proteoglycan degradation and nitric oxide production in bovine articular cartilage/chondrocyte cultures by the natural product, hymenialdisine

Applications of micro-CT and MR microscopy to study pre-clinical models of osteoporosis and osteoarthritis

Idoxifene, a novel selective estrogen receptor modulator, is effective in a rat model of adjuvant-induced arthritis

Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization

First Human Dosing Experience with TRV130, a Biased Ligand at the Mu Opioid Receptor (P02.013)

An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation

The new partnership of genomics and chemistry for accelerated drug development

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone

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