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Blood-brain barrier permeation: molecular parameters governing passive diffusion

The Journal of membrane biology, 1998-10, Vol.165 (3), p.201-211

1998

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Role of blood‐brain barrier P‐glycoprotein in limiting brain accumulation and sedative side‐effects of asimadoline, a peripherally acting analgaesic drug

British journal of pharmacology, 1999-05, Vol.127 (1), p.43-50

1999

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Novel developments with selective, non-peptidic kappa-opioid receptor agonists

Expert opinion on investigational drugs, 1997-10, Vol.6 (10), p.1351-1368

1997

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A Method to Determine the Ability of Drugs to Diffuse through the Blood- Brain Barrier

Proceedings of the National Academy of Sciences - PNAS, 1994-01, Vol.91 (1), p.68-72

1994

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Synthesis of Novel 2-Aminothiophene-3-carboxylates by Variations of the Gewald Reaction

Monatshefte für Chemie, 2001-02, Vol.132 (2), p.279-293

2001

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A pharmacological profile of the novel, peripherally-selective κ-opioid receptor agonist, EMD 61753

British journal of pharmacology, 1994-12, Vol.113 (4), p.1317-1327

1994

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Synthesis of Thieno[2,3-b]Pyridinones Acting as Cytoprotectants and as Inhibitors of [3H]Glycine Binding to the N-Methyl-d-aspartate (NMDA) Receptor

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.864-871

2006

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(5S)-3-aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors

Bioorganic & medicinal chemistry letters, 1992, Vol.2 (2), p.165-170

1992

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Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation

Medicinal research reviews, 1992-09, Vol.12 (5), p.525-562

1992

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EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonists

Bioorganic & medicinal chemistry letters, 1994-03, Vol.4 (5), p.677-682

1994

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Central and peripheral actions of the novel κ‐opioid receptor agonist, EMD 60400

British journal of pharmacology, 1994-03, Vol.111 (3), p.843-851

1994

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A pharmacological profile of the novel, peripherally‐selective k‐opioid receptor agonist, EMD 61753

British journal of pharmacology, 1994-12, Vol.113 (4), p.1317-1327

1994

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Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat

Methods and Findings in Experimental and Clinical Pharmacology, 1999-03, Vol.21 (2), p.105-113

1999

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The peripherally acting kappa-opiate agonist EMD 61753 and analogues: opioid activity versus peripheral selectivity

Drugs under experimental and clinical research, 1995, Vol.21 (5), p.171

1995

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Metabolic fate of diethylstilbestrol in the Syrian golden hamster, a susceptible species for diethylstilbestrol carcinogenicity

Xenobiotica, 1980-01, Vol.10 (5), p.317-327

1980

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Oxidative metabolites of the teratogen and transplacental carcinogen diethylstilbestrol in the fetal Syrian golden hamster

Journal of environmental pathology, toxicology and oncology, 1984-07, Vol.5 (4-5), p.329

1984

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K-Opioid activity of the four stereoisomers of the peripherally selective κ-agonists, EMD 60 400 and emd 61 753

Chirality (New York, N.Y.), 1994, Vol.6 (8), p.685-689

1994

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ChemInform Abstract: Chemical Graphology

ChemInform, 1993-08, Vol.24 (31), p.no-no

GOTTSCHLICH, R.

1993

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kappa-Opioid activity of the four stereoisomers of the peripherally selective kappa-agonists, EMD 60,400 and EMD 61,753

Chirality (New York, N.Y.), 1994, Vol.6 (8), p.685-689

1994

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High-pressure, reverse-phase partition chromatograhy separation of diethylstilbestrol metabolites and analogs

Analytical biochemistry, 1979-01, Vol.92 (1), p.199

1979

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ChemInform Abstract: SUBSTITUTES FOR PHOSGENE IN ORGANIC SYNTHESIS

Chemischer Informationsdienst, 1981-07, Vol.12 (30)

GOTTSCHLICH, R.

1981

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ChemInform Abstract: ZUR MESSUNG VON RK.‐KINETIKEN, ACYLIERUNG VON HYDROXY‐ UND AMINOVERBINDUNGEN

Chemischer Informationsdienst, 1972-09, Vol.3 (36)

GOTTSCHLICH, R.

1972

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Effects of GR-89696 and the novel peripherally selective OP2agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat

Methods and findings in experimental and clinical pharmacology, 1999, Vol.21 (2), p.105-113

1999

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High-pressure, reverse-phase partition chromatography separation of diethylstilbestrol metabolites and analogs

Analytical biochemistry, 1979, Vol.92 (1), p.199-202

1979

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Nitrefazole, a 4-nitroimidazole derivative with a marked inhibitory effect on aldehyde dehydrogenase. Synthesis and structural assignment

Arzneimittel-Forschung, 1985, Vol.35 (8), p.1220

1985

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Blood-brain barrier permeation: molecular parameters governing passive diffusion

Role of blood‐brain barrier P‐glycoprotein in limiting brain accumulation and sedative side‐effects of asimadoline, a peripherally acting analgaesic drug

Novel developments with selective, non-peptidic kappa-opioid receptor agonists

A Method to Determine the Ability of Drugs to Diffuse through the Blood- Brain Barrier

Synthesis of Novel 2-Aminothiophene-3-carboxylates by Variations of the Gewald Reaction

A pharmacological profile of the novel, peripherally-selective κ-opioid receptor agonist, EMD 61753

Synthesis of Thieno[2,3-b]Pyridinones Acting as Cytoprotectants and as Inhibitors of [3H]Glycine Binding to the N-Methyl-d-aspartate (NMDA) Receptor

(5S)-3-aryl-5-(1-piperidinylmethyl)-2-oxazolidinones, a new class of potential neuroleptics with a high affinity for sigma receptors

Opioid agonists and antagonists: An evaluation of their peripheral actions in inflammation

EMD 61 753 as a favourable representative of structurally novel arylacetamido-type K opiate receptor agonists

Central and peripheral actions of the novel κ‐opioid receptor agonist, EMD 60400

A pharmacological profile of the novel, peripherally‐selective k‐opioid receptor agonist, EMD 61753

Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat

The peripherally acting kappa-opiate agonist EMD 61753 and analogues: opioid activity versus peripheral selectivity

Metabolic fate of diethylstilbestrol in the Syrian golden hamster, a susceptible species for diethylstilbestrol carcinogenicity

Oxidative metabolites of the teratogen and transplacental carcinogen diethylstilbestrol in the fetal Syrian golden hamster

K-Opioid activity of the four stereoisomers of the peripherally selective κ-agonists, EMD 60 400 and emd 61 753

ChemInform Abstract: Chemical Graphology

kappa-Opioid activity of the four stereoisomers of the peripherally selective kappa-agonists, EMD 60,400 and EMD 61,753

High-pressure, reverse-phase partition chromatograhy separation of diethylstilbestrol metabolites and analogs

ChemInform Abstract: SUBSTITUTES FOR PHOSGENE IN ORGANIC SYNTHESIS

ChemInform Abstract: ZUR MESSUNG VON RK.‐KINETIKEN, ACYLIERUNG VON HYDROXY‐ UND AMINOVERBINDUNGEN

Effects of GR-89696 and the novel peripherally selective OP2agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat

High-pressure, reverse-phase partition chromatography separation of diethylstilbestrol metabolites and analogs

Nitrefazole, a 4-nitroimidazole derivative with a marked inhibitory effect on aldehyde dehydrogenase. Synthesis and structural assignment

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