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The chemistry and biological profile of trovafloxacin

Journal of antimicrobial chemotherapy, 1997-06, Vol.39 Suppl B (suppl 2), p.1-14

1997

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The global problem of antibiotic resistance

Critical reviews in immunology, 2010, Vol.30 (1), p.79-93

Gootz, Thomas D

2010

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Fluoroquinolone antibacterials: SAR, mechanism of action, resistance, and clinical aspects

Medicinal research reviews, 1996-09, Vol.16 (5), p.433-486

1996

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Genetic and Molecular Characterization of β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae with Unusually High Resistance to Ampicillin

Antimicrobial Agents and Chemotherapy, 2004-05, Vol.48 (5), p.1630-1639

2004

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Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro

Antimicrobial Agents and Chemotherapy, 1996-12, Vol.40 (12), p.2691-2697

1996

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Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus

Antimicrobial agents and chemotherapy, 1999-08, Vol.43 (8), p.1845-1855

1999

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Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage

The Journal of biological chemistry, 1991-08, Vol.266 (22), p.14585-14592

1991

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In vivo efficacy of trovafloxacin (CP-99,219), a new quinolone with extended activities against gram-positive pathogens, Streptococcus pneumoniae, and Bacteroides fragilis

Antimicrobial Agents and Chemotherapy, 1995-10, Vol.39 (10), p.2210-2216

1995

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O496 Multiresistant Klebsiella pneumoniae from NYC hospitals contain β-lactamase KPC-2 or KPC-3 and porin changes

International journal of antimicrobial agents, 2007, Vol.29, p.S107-S108

2007

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Bactericidal assays for fluoroquinolones

Methods in molecular biology (Clifton, N.J.), 2001, Vol.95, p.185

Gootz, T D

2001

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Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

Antimicrobial Agents and Chemotherapy, 1993-10, Vol.37 (10), p.2179-2186

1993

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Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution

Antimicrobial Agents and Chemotherapy, 1987-12, Vol.31 (12), p.1948-1954

1987

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Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

Antimicrobial Agents and Chemotherapy, 1992-04, Vol.36 (4), p.751-756

1992

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Characterization of high-level quinolone resistance in Campylobacter jejuni

Antimicrobial Agents and Chemotherapy, 1991-05, Vol.35 (5), p.840-845

1991

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Pharmacokinetics of trovafloxacin (CP-99,219), a new quinolone, in rats, dogs, and monkeys

Antimicrobial Agents and Chemotherapy, 1996-03, Vol.40 (3), p.561-566

1996

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In-vitro and in-vivo activity of trovafloxacin against Streptococcus pneumoniae

Journal of antimicrobial chemotherapy, 1997-06, Vol.39 Suppl B (suppl 2), p.51-55

1997

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Topoisomerase IV Catalysis and the Mechanism of Quinolone Action

The Journal of biological chemistry, 1998-07, Vol.273 (28), p.17879-17885

1998

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Anti-Toxoplasma gondii Activities and Structure-Activity Relationships of Novel Fluoroquinolones Related to Trovafloxacin

Antimicrobial Agents and Chemotherapy, 1999-07, Vol.43 (7), p.1783-1787

1999

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High-level quinolone resistance in clinical isolates of Campylobacter jejuni

The Journal of infectious diseases, 1992-04, Vol.165 (4), p.667-670

1992

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Cloning and Functional Characterization of an NAD+-Dependent DNA Ligase from Staphylococcus aureus

Journal of Bacteriology, 2001-05, Vol.183 (10), p.3016-3024

2001

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CJ-12, 954 and Its Congeners, New Anti-Helicobacter pylori Compounds Produced by Phanerochaete velutina: Fermentation, Isolation, Structural Elucidation and Biological Activities

The Journal of Antibiotics, 1997/10/25, Vol.50(10), pp.833-839

1997

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The Spread of Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae to Upstate New York

Clinical infectious diseases, 2006-08, Vol.43 (3), p.e26-e28

2006

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Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase

Antimicrobial Agents and Chemotherapy, 1994-01, Vol.38 (1), p.130-133

1994

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In vitro activity of CP-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial

Diagnostic microbiology and infectious disease, 1994-08, Vol.19 (4), p.235-243

1994

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Bisulfite or sulfite inhibits growth of Helicobacter pylori

Journal of Clinical Microbiology, 1994-03, Vol.32 (3), p.790-792

1994

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The chemistry and biological profile of trovafloxacin

The global problem of antibiotic resistance

Fluoroquinolone antibacterials: SAR, mechanism of action, resistance, and clinical aspects

Genetic and Molecular Characterization of β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae with Unusually High Resistance to Ampicillin

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro

Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus

Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage

In vivo efficacy of trovafloxacin (CP-99,219), a new quinolone with extended activities against gram-positive pathogens, Streptococcus pneumoniae, and Bacteroides fragilis

O496 Multiresistant Klebsiella pneumoniae from NYC hospitals contain β-lactamase KPC-2 or KPC-3 and porin changes

Bactericidal assays for fluoroquinolones

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

Characterization of high-level quinolone resistance in Campylobacter jejuni

Pharmacokinetics of trovafloxacin (CP-99,219), a new quinolone, in rats, dogs, and monkeys

In-vitro and in-vivo activity of trovafloxacin against Streptococcus pneumoniae

Topoisomerase IV Catalysis and the Mechanism of Quinolone Action

Anti-Toxoplasma gondii Activities and Structure-Activity Relationships of Novel Fluoroquinolones Related to Trovafloxacin

High-level quinolone resistance in clinical isolates of Campylobacter jejuni

Cloning and Functional Characterization of an NAD+-Dependent DNA Ligase from Staphylococcus aureus

CJ-12, 954 and Its Congeners, New Anti-Helicobacter pylori Compounds Produced by Phanerochaete velutina: Fermentation, Isolation, Structural Elucidation and Biological Activities

The Spread of Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae to Upstate New York

Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase

In vitro activity of CP-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial

Bisulfite or sulfite inhibits growth of Helicobacter pylori

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