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Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

PloS one, 2020-01, Vol.15 (1), p.e0227104

2020

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AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

Antimicrobial agents and chemotherapy, 2021-03, Vol.65 (4)

2021

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AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model

PLoS neglected tropical diseases, 2022-01, Vol.16 (1), p.e0009937-e0009937

2022

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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Nature communications, 2022-02, Vol.13 (1), p.621-621, Article 621

2022

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Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses

Antimicrobial agents and chemotherapy, 2021-10, Vol.65 (11), p.e0098821-e0098821

2021

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The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

PLoS biology, 2024-08, Vol.22 (8), p.e3002743

2024

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Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymerase

Expert opinion on investigational drugs, 2024, Vol.33 (1), p.9-17

2024

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Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis

Antimicrobial agents and chemotherapy, 2019-12, Vol.63 (12)

2019

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Overcoming Stability Challenges in the Quantification of Tissue Nucleotides: Determination of 2′-C-Methylguanosine Triphosphate Concentration in Mouse Liver

Biological and Pharmaceutical Bulletin, 2015/03/01, Vol.38(3), pp.380-388

2015

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Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Antimicrobial Agents and Chemotherapy, 2002-08, Vol.46 (8), p.2365-2372

2002

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Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2′-methylguanosine-5′-monophosphate, in the monkey and formulation optimization for human exposure

European journal of drug metabolism and pharmacokinetics, 2016-10, Vol.41 (5), p.567-574

2016

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SAT-411 Absorption, distribution, metabolism, and excretion of [14C]-Bemnifosbuvir in the rats

Journal of hepatology, 2024-06, Vol.80, p.S753-S753

2024

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Paleoenvironmental and paleoclimatic significance of freshwater bivalves in the Upper Jurassic Morrison Formation, Western Interior, USA

Sedimentary geology, 2004-05, Vol.167 (3), p.163-176

Good, Steven C

2004

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Estimation of Human Drug Clearance Using Multiexponential Techniques

Journal of clinical pharmacology, 2008-10, Vol.48 (10), p.1226-1236

2008

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Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication

Antimicrobial Agents and Chemotherapy, 2002-08, Vol.46 (8), p.2373-2380

2002

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SAT-402 Bemnifosbuvir is a potent HCV NS5B inhibitor with a favorable antiviral profile and high resistance barrier

Journal of hepatology, 2024-06, Vol.80, p.S749-S749

2024

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The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution

PLoS biology, 2024-02

2024

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Metabolism of 5-Fluorocytosine to 5-Fluorouracil in Human Colorectal Tumor Cells Transduced with the Cytosine Deaminase Gene: Significant Antitumor Effects when Only a Small Percentage of Tumor Cells Express Cytosine Deaminase

Proceedings of the National Academy of Sciences - PNAS, 1994-08, Vol.91 (17), p.8302-8306

1994

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An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex

Nucleic acids research, 2024-02, Vol.52 (3), p.1325-1340

2024

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A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects

Journal of hepatology, 2020-08, Vol.73, p.S357

2020

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THU438 - A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects

Journal of hepatology, 2020-08, Vol.73, p.S357-S357

2020

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In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase

Cancer research (Chicago, Ill.), 1993-10, Vol.53 (19), p.4619-4626

1993

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Bidder’s Choice Cap Rate Auctions: A New Strategy for Selling Real Estate Portfolios

Journal of real estate practice and education, 2009-01, Vol.12 (1), p.57-80

2009

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1265. AT-527, an Oral Purine Nucleotide Prodrug Exhibiting Potent In Vitro Antiviral Activity Against Human Coronaviruses, Including SARS-CoV-2

Open forum infectious diseases, 2020-12, Vol.7 (Supplement_1), p.S649-S649

2020

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169. AT-752, an Oral Guanosine Nucleotide Prodrug, Exhibits Potent in Vitro Activity Against Flaviviruses and Prevents Disease Progression in a Dengue Mouse Model

Open forum infectious diseases, 2020-12, Vol.7 (Supplement_1), p.S213-S214

2020

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Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19

AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses

The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

Bemnifosbuvir (BEM, AT-527), a novel nucleotide analogue inhibitor of the hepatitis C virus NS5B polymerase

Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis

Overcoming Stability Challenges in the Quantification of Tissue Nucleotides: Determination of 2′-C-Methylguanosine Triphosphate Concentration in Mouse Liver

Potent and Selective Inhibition of Human Cytomegalovirus Replication by 1263W94, a Benzimidazole l-Riboside with a Unique Mode of Action

Pharmacokinetics of IDX184, a liver-targeted oral prodrug of 2′-methylguanosine-5′-monophosphate, in the monkey and formulation optimization for human exposure

SAT-411 Absorption, distribution, metabolism, and excretion of [14C]-Bemnifosbuvir in the rats

Paleoenvironmental and paleoclimatic significance of freshwater bivalves in the Upper Jurassic Morrison Formation, Western Interior, USA

Estimation of Human Drug Clearance Using Multiexponential Techniques

Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication

SAT-402 Bemnifosbuvir is a potent HCV NS5B inhibitor with a favorable antiviral profile and high resistance barrier

The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution

Metabolism of 5-Fluorocytosine to 5-Fluorouracil in Human Colorectal Tumor Cells Transduced with the Cytosine Deaminase Gene: Significant Antitumor Effects when Only a Small Percentage of Tumor Cells Express Cytosine Deaminase

An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex

A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects

THU438 - A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase

Bidder’s Choice Cap Rate Auctions: A New Strategy for Selling Real Estate Portfolios

1265. AT-527, an Oral Purine Nucleotide Prodrug Exhibiting Potent In Vitro Antiviral Activity Against Human Coronaviruses, Including SARS-CoV-2

169. AT-752, an Oral Guanosine Nucleotide Prodrug, Exhibits Potent in Vitro Activity Against Flaviviruses and Prevents Disease Progression in a Dengue Mouse Model

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