UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Identification of (R)‑N‑((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)‑1H‑indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B‑Cell Lymphomas

Journal of medicinal chemistry, 2016-11, Vol.59 (21), p.9928-9941

2016

Volltextzugriff (PDF)

Molecular Shape and Medicinal Chemistry: A Perspective

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.3862-3886

2010

Volltextzugriff (PDF)

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl‑1 Proteins

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2962-2972

2018

Volltextzugriff (PDF)

Optimization of CAMD techniques 3. Virtual screening enrichment studies: a help or hindrance in tool selection?

Journal of computer-aided molecular design, 2008-03, Vol.22 (3-4), p.169-178

2008

Volltextzugriff (PDF)

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

Journal of medicinal chemistry, 2016-06, Vol.59 (11), p.5391-5402

2016

Volltextzugriff (PDF)

Discovery, design, and synthesis of indole-based EZH2 inhibitors

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3644-3649

2015

Volltextzugriff (PDF)

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.11177-11186

2022

Volltextzugriff (PDF)

Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1708-1729

2014

Volltextzugriff (PDF)

Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design

Journal of medicinal chemistry, 2012-03, Vol.55 (6), p.2641-2648

2012

Volltextzugriff (PDF)

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein–Protein Interaction Site

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.22-26

2017

Volltextzugriff (PDF)

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.143-148

2018

Volltextzugriff (PDF)

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9208-9223

2012

Volltextzugriff (PDF)

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1853-1859

2018

Volltextzugriff (PDF)

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.590-596

2017

Volltextzugriff (PDF)

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1995-2012

2014

Volltextzugriff (PDF)

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5040-5047

2015

Volltextzugriff (PDF)

An Empirical Process for the Design of High-Throughput Screening Deck Filters

Journal of chemical information and modeling, 2006-05, Vol.46 (3), p.1060-1068

2006

Volltextzugriff (PDF)

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.779-784

2013

Volltextzugriff (PDF)

Measuring CAMD technique performance: A virtual screening case study in the design of validation experiments

Journal of computer-aided molecular design, 2004-07, Vol.18 (7-9), p.529-536

2004

Volltextzugriff (PDF)

Incidence and characterization of diagnosed endometriosis in a geographically defined population

Fertility and sterility, 2004-08, Vol.82 (2), p.314-321

2004

Volltextzugriff (PDF)

HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (15), p.4428-4435

2013

Volltextzugriff (PDF)

Measuring CAMD Technique Performance. 2. How “Druglike” Are Drugs? Implications of Random Test Set Selection Exemplified Using Druglikeness Classification Models

Journal of chemical information and modeling, 2007-01, Vol.47 (1), p.110-114

2007

Volltextzugriff (PDF)

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6916-6924

2011

Volltextzugriff (PDF)

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6909-6915

2011

Volltextzugriff (PDF)

Wake field study of tidal turbines under realistic flow conditions

Renewable energy, 2020-05, Vol.151, p.1196-1208

2020

Volltextzugriff (PDF)

1 – 25 von 582

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(501)
Mit Volltextzugriff
(475)

Publikationsform

3 weitere anzeigen...

Weniger anzeigen...

Sprache

Erscheinungsjahr

n.n

Thema

15 weitere anzeigen...

Weniger anzeigen...

Kollektion

15 weitere anzeigen...

Weniger anzeigen...

Neu hinzugefügt

... seit 30 Tagen
(1)
... seit 90 Tagen
(10)

Menü

Weitere Dienste

Einstellungen

Molecular Shape and Medicinal Chemistry: A Perspective

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl‑1 Proteins

Optimization of CAMD techniques 3. Virtual screening enrichment studies: a help or hindrance in tool selection?

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

Discovery, design, and synthesis of indole-based EZH2 inhibitors

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1

Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein–Protein Interaction Site

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

An Empirical Process for the Design of High-Throughput Screening Deck Filters

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies

Measuring CAMD technique performance: A virtual screening case study in the design of validation experiments

Incidence and characterization of diagnosed endometriosis in a geographically defined population

HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives

Measuring CAMD Technique Performance. 2. How “Druglike” Are Drugs? Implications of Random Test Set Selection Exemplified Using Druglikeness Classification Models

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors

Wake field study of tidal turbines under realistic flow conditions

Suchergebnisse filtern