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Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma

Oncogene, 2008-08, Vol.27 (35), p.4830-4840

2008

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Irradiation-induced angiogenesis is associated with an MMP-9-miR-494-syndecan-1 regulatory loop in medulloblastoma cells

Oncogene, 2014-04, Vol.33 (15), p.1922-1933

2014

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Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma

Cancer gene therapy, 2011-06, Vol.18 (6), p.419-434

2011

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Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis

Oncogene, 2004-06, Vol.23 (27), p.4681-4689

2004

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RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas

Oncogene, 2004-11, Vol.23 (52), p.8486-8496

2004

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Elevated levels of cathepsin B in human glioblastoma cell lines

International journal of oncology, 2001-09, Vol.19 (3), p.519

2001

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Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis

Oncogene, 2003-09, Vol.22 (38), p.5967-5975

2003

Volltextzugriff (PDF)

Synergistic down-regulation of urokinase plasminogen activator receptor and matrix metalloproteinase-9 in SNB19 glioblastoma cells efficiently inhibits glioma cell invasion, angiogenesis, and tumor growth

Cancer research (Chicago, Ill.), 2003-05, Vol.63 (10), p.2454-2461

2003

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Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes

The Journal of biological chemistry, 2001-12, Vol.276 (50), p.47171

2001

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uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells

Neuro-oncology (Charlottesville, Va.), 2012-06, Vol.14 (6), p.745-760

2012

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RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis

International journal of oncology, 2007-11, Vol.31 (5), p.1039-1050

2007

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Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metalloproteinases

Methods in molecular biology (Clifton, N.J.), 2009, Vol.487, p.267

2009

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RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits Prostate Cancer Cell Invasion, Survival, and Tumorigenicity in Vivo

The Journal of biological chemistry, 2005-10, Vol.280 (43), p.36529-36540

2005

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SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA

International journal of oncology, 2006-12, Vol.29 (6), p.1349-1357

2006

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Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line

International journal of oncology, 2006-07, Vol.29 (1), p.25-32

2006

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RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells

International journal of oncology, 2009-10, Vol.35 (4), p.851-859

2009

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Proteases and Glioma Angiogenesis

Brain pathology (Zurich, Switzerland), 2005-10, Vol.15 (4), p.327-341

2005

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MMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts

International journal of oncology, 2009-08, Vol.35 (2), p.257-263

2009

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Specific Interference of Urokinase-type Plasminogen Activator Receptor and Matrix Metalloproteinase-9 Gene Expression Induced by Double-stranded RNA Results in Decreased Invasion, Tumor Growth, and Angiogenesis in Gliomas

The Journal of biological chemistry, 2005-06, Vol.280 (23), p.21882-21892

2005

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Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells

International journal of oncology, 2010-05, Vol.36 (5), p.1165-1173

2010

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Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas

International journal of oncology, 2008-10, Vol.33 (4), p.783-790

2008

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siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells

International journal of oncology, 2006-04, Vol.28 (4), p.831-839

2006

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Recombinant adeno‐associated virus (rAAV) expressing TFPI‐2 inhibits invasion, angiogenesis and tumor growth in a human glioblastoma cell line

International journal of cancer, 2005-07, Vol.115 (6), p.998-1005

2005

Volltextzugriff (PDF)

Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas

Cancer research (Chicago, Ill.), 2004-06, Vol.64 (12), p.4069-4077

2004

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Regression of pre-established intracranial tumor growth by ON 01910.Na, a selective anticancer agent currently in phase I trials

Journal of clinical oncology, 2006-06, Vol.24 (18_suppl), p.1576-1576

2006

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Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma

Irradiation-induced angiogenesis is associated with an MMP-9-miR-494-syndecan-1 regulatory loop in medulloblastoma cells

Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis

RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion, angiogenesis and tumor growth in gliomas

Elevated levels of cathepsin B in human glioblastoma cell lines

Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis

Synergistic down-regulation of urokinase plasminogen activator receptor and matrix metalloproteinase-9 in SNB19 glioblastoma cells efficiently inhibits glioma cell invasion, angiogenesis, and tumor growth

Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes

uPAR and cathepsin B inhibition enhanced radiation-induced apoptosis in gliomainitiating cells

RNAi-mediated abrogation of cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth, invasion and angiogenesis

Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metalloproteinases

RNA Interference-directed Knockdown of Urokinase Plasminogen Activator and Urokinase Plasminogen Activator Receptor Inhibits Prostate Cancer Cell Invasion, Survival, and Tumorigenicity in Vivo

SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA

Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line

RNAi-mediated downregulation of MMP-2 activates the extrinsic apoptotic pathway in human glioma xenograft cells

Proteases and Glioma Angiogenesis

MMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts

Specific Interference of Urokinase-type Plasminogen Activator Receptor and Matrix Metalloproteinase-9 Gene Expression Induced by Double-stranded RNA Results in Decreased Invasion, Tumor Growth, and Angiogenesis in Gliomas

Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells

Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas

siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells

Recombinant adeno‐associated virus (rAAV) expressing TFPI‐2 inhibits invasion, angiogenesis and tumor growth in a human glioblastoma cell line

Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas

Regression of pre-established intracranial tumor growth by ON 01910.Na, a selective anticancer agent currently in phase I trials

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