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Role and potential for therapeutic targeting of MYB in leukemia

Leukemia, 2013-02, Vol.27 (2), p.269-277

2013

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PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

British journal of cancer, 2011-02, Vol.104 (4), p.635-642

2011

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The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

Investigational new drugs, 2010-06, Vol.28 (3), p.276-283

2010

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Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells

Oncology letters, 2018-04, Vol.15 (4), p.4289-4295

2018

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A family of cytokine-inducible inhibitors of signalling

Nature (London), 1997-06, Vol.387 (6636), p.917-921

1997

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Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling

Cell death and differentiation, 2009-11, Vol.16 (11), p.1530-1538

2009

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A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability

Oncogene, 2011-01, Vol.30 (2), p.212-222

2011

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Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

Oncogene, 2017-11, Vol.36 (46), p.6490-6500

2017

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The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1

Oncogene, 2014-08, Vol.33 (35), p.4442-4449

2014

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Repression of Gadd45α by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation

Leukemia, 2009-04, Vol.23 (4), p.729-738

2009

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Functional expression cloning reveals proapoptotic role for protein phosphatase 4

Cell death and differentiation, 2003-09, Vol.10 (9), p.1016-1024

2003

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Delineation of Three Functional Domains of the Transcriptional Activator Encoded by the C-myb Protooncogene

Proceedings of the National Academy of Sciences - PNAS, 1989-08, Vol.86 (15), p.5758-5762

1989

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A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector

Molecular and Cellular Biology, 1994-02, Vol.14 (2), p.880-887

1994

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Detection of proteins that bind to the leucine zipper motif of c-Myb

Oncogene, 1994, Vol.9 (1), p.305-311

1994

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Expression of myb , myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia

Nature (London), 1984-01, Vol.310 (5974), p.249-251

1984

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Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2

Oncogene, 1997-12, Vol.15 (24), p.2885-2898

1997

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A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte‐macrophage colony stimulating factor

The EMBO journal, 1989-02, Vol.8 (2), p.441-448

1989

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Transactivation and Transformation by Myb are Negatively Regulated by a Leucine-Zipper Structure

Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (7), p.3088-3092

1992

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Activating point mutations in the common beta subunit of the human GM‐CSF, IL‐3 and IL‐5 receptors suggest the involvement of beta subunit dimerization and cell type‐specific molecules in signalling

The EMBO journal, 1995-09, Vol.14 (17), p.4276-4287

1995

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Activating mutations in cytokine receptors : Implications for receptor function and role in disease

Blood, 1997-01, Vol.89 (2), p.355-369

1997

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Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper

The Journal of biological chemistry, 1993-10, Vol.268 (29), p.21914-21923

1993

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Saturation mutagenesis of the β subunit of the human granulocyte-macrophage colony-stimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential β subunit tyrosine phosphorylation

Blood, 1998-09, Vol.92 (6), p.1989-2002

1998

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The c-Myb oncoprotein

The international journal of biochemistry & cell biology, 1998-05, Vol.30 (5), p.547-551

Gonda, Thomas J

1998

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Expression of constitutively activated human c-Kit in Myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity

Blood, 1997-12, Vol.90 (11), p.4539-4552

1997

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Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common β subunit

Oncogene, 1999-12, Vol.18 (51), p.7190-7199

1999

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Role and potential for therapeutic targeting of MYB in leukemia

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells

A family of cytokine-inducible inhibitors of signalling

Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling

A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

The MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1

Repression of Gadd45α by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation

Functional expression cloning reveals proapoptotic role for protein phosphatase 4

Delineation of Three Functional Domains of the Transcriptional Activator Encoded by the C-myb Protooncogene

A simple and efficient procedure for generating stable expression libraries by cDNA cloning in a retroviral vector

Detection of proteins that bind to the leucine zipper motif of c-Myb

Expression of myb , myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia

Inactivation of a c-Myb/estrogen receptor fusion protein in transformed primary cells leads to granulocyte/macrophage differentiation and down regulation of c-kit but not c-myc or cdc2

A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte‐macrophage colony stimulating factor

Transactivation and Transformation by Myb are Negatively Regulated by a Leucine-Zipper Structure

Activating point mutations in the common beta subunit of the human GM‐CSF, IL‐3 and IL‐5 receptors suggest the involvement of beta subunit dimerization and cell type‐specific molecules in signalling

Activating mutations in cytokine receptors : Implications for receptor function and role in disease

Negative autoregulation of c-Myb activity by homodimer formation through the leucine zipper

Saturation mutagenesis of the β subunit of the human granulocyte-macrophage colony-stimulating factor receptor shows clustering of constitutive mutations, activation of ERK MAP kinase and STAT pathways, and differential β subunit tyrosine phosphorylation

The c-Myb oncoprotein

Expression of constitutively activated human c-Kit in Myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity

Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common β subunit

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