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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats

The Journal of pharmacology and experimental therapeutics, 2005-07, Vol.314 (1), p.410

2005

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Additive Antinociceptive Effects of the Selective Nav1.8 Blocker A-803467 and Selective TRPV1 Antagonists in Rat Inflammatory and Neuropathic Pain Models

The journal of pain, 2009-03, Vol.10 (3), p.306-315

2009

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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid

The Journal of pharmacology and experimental therapeutics, 2005-07, Vol.314 (1), p.400

2005

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(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.879

2008

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Vanilloid receptor TRPV1 in drug discovery: targeting pain and other pathological disorders

1, 2010

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Targeting TRP channels: beyond TRPV1

Naunyn-Schmiedeberg's archives of pharmacology, 2015-04, Vol.388 (4), p.387-388

2015

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Nonnucleoside inhibitors of adenosine kinase

Current pharmaceutical design, 2004-01, Vol.10 (10), p.1093

2004

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Asymmetric synthesis of enantiomerically pure and diversely functionalized cyclopropanes

Journal of the American Chemical Society, , Vol.117 (41), p.10393-10394

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[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor

The Journal of pharmacology and experimental therapeutics, 2007-10, Vol.323 (1), p.285

2007

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Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.417-429

2021

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Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature

The Journal of pharmacology and experimental therapeutics, 2012-08, Vol.342 (2), p.416

2012

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Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid‑3 (TRPV3) Antagonist

Journal of organic chemistry, 2016-12, Vol.81 (23), p.12060-12064

2016

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Direct Synthesis of β-Aminoketones from Amides via Novel Sequential Nucleophilic Substitution/Michael Reaction

Organic letters, 2000-01, Vol.2 (1), p.11-13

Gomtsyan, Arthur

2000

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TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats

Journal of neurophysiology, 2017-08, Vol.118 (2), p.904-916

2017

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Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.392-395

2008

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Asymmetric conjugate additions of chiral allyl- and crotylphosphonamide anions to .alpha.,.beta.-unsaturated carbonyl compounds: highly stereocontrolled access to vicinally substituted carbon centers and chemically asymmetrized chirons

Journal of organic chemistry, 1993-09, Vol.58 (19), p.5032-5034

1993

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Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (5), p.1338-1341

2011

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Vanilloid receptor TRPV1 in drug discovery: targeting pain and other pathological disorders

2010

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TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats

Temperature (Austin), 2015-06, Vol.2 (2), p.297-301

2015

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Asymmetric Conjugate Additions of Chiral Phosphonamide Anions to α,β-Unsaturated Carbonyl Compounds. A Versatile Method for Vicinally Substituted Chirons

Journal of organic chemistry, 2000-09, Vol.65 (18), p.5623-5631

2000

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In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists

Journal of medicinal chemistry, 2007-07, Vol.50 (15), p.3651-3660

2007

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A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats

Discovery of (R)‑1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid‑1 (TRPV1) Antagonist with Analgesic Efficacy

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

Additive Antinociceptive Effects of the Selective Nav1.8 Blocker A-803467 and Selective TRPV1 Antagonists in Rat Inflammatory and Neuropathic Pain Models

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid

(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo

Vanilloid receptor TRPV1 in drug discovery: targeting pain and other pathological disorders

Targeting TRP channels: beyond TRPV1

Nonnucleoside inhibitors of adenosine kinase

Asymmetric synthesis of enantiomerically pure and diversely functionalized cyclopropanes

[3H]A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design

Pharmacology of modality-specific transient receptor potential vanilloid-1 antagonists that do not alter body temperature

Stereoselective Synthesis of a Dipyridyl Transient Receptor Potential Vanilloid‑3 (TRPV3) Antagonist

Direct Synthesis of β-Aminoketones from Amides via Novel Sequential Nucleophilic Substitution/Michael Reaction

TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats

Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists

Novel Transient Receptor Potential Vanilloid 1 Receptor Antagonists for the Treatment of Pain: Structure−Activity Relationships for Ureas with Quinoline, Isoquinoline, Quinazoline, Phthalazine, Quinoxaline, and Cinnoline Moieties

Asymmetric conjugate additions of chiral allyl- and crotylphosphonamide anions to .alpha.,.beta.-unsaturated carbonyl compounds: highly stereocontrolled access to vicinally substituted carbon centers and chemically asymmetrized chirons

Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists

Vanilloid receptor TRPV1 in drug discovery: targeting pain and other pathological disorders

TRPV1 ligands with hyperthermic, hypothermic and no temperature effects in rats

Asymmetric Conjugate Additions of Chiral Phosphonamide Anions to α,β-Unsaturated Carbonyl Compounds. A Versatile Method for Vicinally Substituted Chirons

In Vitro Structure−Activity Relationship and In Vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea Transient Receptor Potential Vanilloid 1 Antagonists

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