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Effect of the Phosphate Binders Sevelamer Carbonate and Calcium Acetate on the Pharmacokinetics of Roxadustat After Concomitant or Time-separated Administration in Healthy Individuals

Clinical therapeutics, 2021-06, Vol.43 (6), p.1079-1091

2021

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Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects

Journal of psychopharmacology (Oxford), 2018-12, Vol.32 (12), p.1330-1340

2018

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First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection

British journal of clinical pharmacology, 2021-02, Vol.87 (2), p.598-611

2021

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The Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat (FG-4592) and Warfarin in Healthy Volunteers: A Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction Study

Clinical therapeutics, 2016-04, Vol.38 (4), p.918-928

2016

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Effect of the Proton Pump Inhibitor Esomeprazole on the Oral Absorption and Pharmacokinetics of Nilotinib

Journal of clinical pharmacology, 2010-08, Vol.50 (8), p.960-967

2010

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Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects

European journal of drug metabolism and pharmacokinetics, 2018-12, Vol.43 (6), p.685-692

2018

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A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers

Drug design, development and therapy, 2012, Vol.6 (default), p.71-79

2012

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Safety of Hydroxocobalamin in Healthy Volunteers in a Randomized, Placebo-Controlled Study

Clinical toxicology (Philadelphia, Pa.), 2006-01, Vol.44 (S1), p.17-28

2006

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Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study

Clinical pharmacology in drug development, 2014-09, Vol.3 (5), p.388-395

2014

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First‐in‐human study with ACT‐539313, a novel selective orexin‐1 receptor antagonist

British journal of clinical pharmacology, 2020-07, Vol.86 (7), p.1377-1386

2020

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The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1149

2007

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Management of hyperglycemia associated with pasireotide (SOM230): Healthy volunteer study

Diabetes research and clinical practice, 2014-03, Vol.103 (3), p.458-465

2014

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Lixisenatide reduces postprandial hyperglycaemia via gastrostatic and insulinotropic effects

Diabetes/metabolism research and reviews, 2015-09, Vol.31 (6), p.610-618

2015

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Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects

Clinical pharmacokinetics, 2017-11, Vol.56 (11), p.1391-1401

2017

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Clinical Pharmacokinetics of Alamifovir and Its Metabolites

Antimicrobial Agents and Chemotherapy, 2005-05, Vol.49 (5), p.1813-1822

2005

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Pharmacodynamic interaction between intravenous nitroglycerin and oral sacubitril/valsartan (LCZ696) in healthy subjects

European journal of clinical pharmacology, 2018-09, Vol.74 (9), p.1121-1130

2018

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A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects

Clinical drug investigation, 2020-05, Vol.40 (5), p.433-447

2020

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No QTc Prolongation with Semaglutide: A Thorough QT Study in Healthy Subjects

Diabetes therapy, 2018-08, Vol.9 (4), p.1441-1456

2018

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THE DNA-BASED THERAPEUTIC AGENT BC 007 COMPLETELY NEUTRALIZES AGONISTIC AUTOANTIBODIES DIRECTED AGAINST β1-ADRENOCEPTORS: RESULTS OF A PHASE 1 TRIAL

Journal of the American College of Cardiology, 2018-03, Vol.71 (11), p.A645-A645

2018

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An Open-Label, Parallel Group Study Investigating the Effects of Age and Gender on the Pharmacokinetics of the Once-Daily Glucagon-Like Peptide-1 Analogue Liraglutide

Journal of clinical pharmacology, 2006-06, Vol.46 (6), p.635-641

2006

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Kinetics and inductive potency of 1,2,3,4,6,7,8-heptachlorodibenzo- p-dioxin (h 7cdd) in rats

Life sciences (1973), 2001-06, Vol.69 (5), p.493-508

2001

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Tissue concentrations and induction of a hepatic monooxygenase in male Wistar rats after repeated doses of defined polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDDs and PCDFs) mixtures

Archives of toxicology, 2002-01, Vol.75 (11-12), p.653-664

2002

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Effects of Yogurt and Applesauce on the Oral Bioavailability of Nilotinib in Healthy Volunteers

Journal of clinical pharmacology, 2011-11, Vol.51 (11), p.1580-1586

2011

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Effects of Nilotinib on Single-Dose Warfarin Pharmacokinetics and Pharmacodynamics: A Randomized, Single-Blind, Two-Period Crossover Study in Healthy Subjects

Clinical drug investigation, 2011-01, Vol.31 (3), p.169-179

2011

Volltextzugriff (PDF)

No Difference in Pharmacokinetic Profile of Liraglutide When Administered as a Single Dose to Young and Elderly Healthy Subjects

Diabetes (New York, N.Y.), 2005-06, Vol.54, p.A114

2005

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Effect of the Phosphate Binders Sevelamer Carbonate and Calcium Acetate on the Pharmacokinetics of Roxadustat After Concomitant or Time-separated Administration in Healthy Individuals

Multiple daytime administration of the selective orexin-2 receptor antagonist JNJ-42847922 induces somnolence in healthy subjects without residual central effects

First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist for endothelial protection

The Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat (FG-4592) and Warfarin in Healthy Volunteers: A Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction Study

Effect of the Proton Pump Inhibitor Esomeprazole on the Oral Absorption and Pharmacokinetics of Nilotinib

Effect of Multiple Doses of Omeprazole on the Pharmacokinetics, Safety, and Tolerability of Roxadustat in Healthy Subjects

A first-in-man study to evaluate the safety, tolerability, and pharmacokinetics of pasireotide (SOM230), a multireceptor-targeted somatostatin analog, in healthy volunteers

Safety of Hydroxocobalamin in Healthy Volunteers in a Randomized, Placebo-Controlled Study

Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study

First‐in‐human study with ACT‐539313, a novel selective orexin‐1 receptor antagonist

The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole

Management of hyperglycemia associated with pasireotide (SOM230): Healthy volunteer study

Lixisenatide reduces postprandial hyperglycaemia via gastrostatic and insulinotropic effects

Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects

Clinical Pharmacokinetics of Alamifovir and Its Metabolites

Pharmacodynamic interaction between intravenous nitroglycerin and oral sacubitril/valsartan (LCZ696) in healthy subjects

A Three-Part, Randomised Study to Investigate the Safety, Tolerability, Pharmacokinetics and Mode of Action of BC 007, Neutraliser of Pathogenic Autoantibodies Against G-Protein Coupled Receptors in Healthy, Young and Elderly Subjects

No QTc Prolongation with Semaglutide: A Thorough QT Study in Healthy Subjects

THE DNA-BASED THERAPEUTIC AGENT BC 007 COMPLETELY NEUTRALIZES AGONISTIC AUTOANTIBODIES DIRECTED AGAINST β1-ADRENOCEPTORS: RESULTS OF A PHASE 1 TRIAL

An Open-Label, Parallel Group Study Investigating the Effects of Age and Gender on the Pharmacokinetics of the Once-Daily Glucagon-Like Peptide-1 Analogue Liraglutide

Kinetics and inductive potency of 1,2,3,4,6,7,8-heptachlorodibenzo- p-dioxin (h 7cdd) in rats

Tissue concentrations and induction of a hepatic monooxygenase in male Wistar rats after repeated doses of defined polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDDs and PCDFs) mixtures

Effects of Yogurt and Applesauce on the Oral Bioavailability of Nilotinib in Healthy Volunteers

Effects of Nilotinib on Single-Dose Warfarin Pharmacokinetics and Pharmacodynamics: A Randomized, Single-Blind, Two-Period Crossover Study in Healthy Subjects

No Difference in Pharmacokinetic Profile of Liraglutide When Administered as a Single Dose to Young and Elderly Healthy Subjects

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