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Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research

Cell, 2012-03, Vol.148 (6), p.1284-1292

2012

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Nature (London), 2013-01, Vol.493 (7434), p.674-678

2013

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Hemolysis-induced lethality involves inflammasome activation by heme

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (39), p.E4110-E4118

2014

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A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

Cell reports (Cambridge), 2016-07, Vol.16 (2), p.571-582

2016

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Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

Immunity (Cambridge, Mass.), 2011-08, Vol.35 (2), p.194-207

2011

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Nature immunology, 2010-02, Vol.11 (2), p.155

2010

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Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

Cell reports (Cambridge), 2014-01, Vol.6 (1), p.196-210

2014

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Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

Cell host & microbe, 2016-07, Vol.20 (1), p.49-59

2016

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Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

Cell host & microbe, 2013-01, Vol.13 (1), p.42-53

2013

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The immunology of Plasmodium vivax malaria

Immunological reviews, 2020-01, Vol.293 (1), p.163-189

2020

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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection

PLoS pathogens, 2014-01, Vol.10 (1), p.e1003885-e1003885

2014

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MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

The Journal of biological chemistry, 2010-03, Vol.285 (12), p.8695-8702

2010

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Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum

The Journal of clinical investigation, 2022-06, Vol.132 (11), p.1-14

2022

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Activation of the NLRP3 inflammasome by group B streptococci

The Journal of immunology (1950), 2012-02, Vol.188 (4), p.1953-1960

2012

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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria

The Journal of immunology (1950), 2018-01, Vol.200 (2), p.768-774

2018

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Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

Cell reports (Cambridge), 2016-06, Vol.15 (11), p.2438-2448

2016

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Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9

The Journal of clinical investigation, 2005-02, Vol.115 (2), p.407-417

2005

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HMGB1 signals through toll-like receptor (TLR) 4 and TLR2

Shock (Augusta, Ga.), 2006-08, Vol.26 (2), p.174-179

2006

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Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (6), p.1919-1924

2007

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Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (24), p.E2209-E2218

2013

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Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice

Proceedings of the National Academy of Sciences - PNAS, 2018-09, Vol.115 (36), p.9002-9007

2018

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The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection

Cell reports (Cambridge), 2024-02, Vol.43 (2), p.113795-113795, Article 113795

2024

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Innate immunity in Alzheimer's disease

Nature immunology, 2015-03, Vol.16 (3), p.229

2015

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Ligand-induced conformational changes allosterically activate Toll-like receptor 9

Nature Immunology, 2007-07, Vol.8 (7), p.772-779

2007

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The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

PLoS pathogens, 2019-03, Vol.15 (3), p.e1007684-e1007684

2019

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Beyond Empiricism: Informing Vaccine Development through Innate Immunity Research

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

Hemolysis-induced lethality involves inflammasome activation by heme

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

The immunology of Plasmodium vivax malaria

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection

MD-2-mediated Ionic Interactions between Lipid A and TLR4 Are Essential for Receptor Activation

Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum

Activation of the NLRP3 inflammasome by group B streptococci

Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9

HMGB1 signals through toll-like receptor (TLR) 4 and TLR2

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice

The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection

Innate immunity in Alzheimer's disease

Ligand-induced conformational changes allosterically activate Toll-like receptor 9

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2

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