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Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors

Molecular aspects of medicine, 2013-04, Vol.34 (2-3), p.373-385

2013

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The intestinal absorption of folates

Annual review of physiology, 2014-01, Vol.76 (1), p.251-274

2014

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The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption

Molecular aspects of medicine, 2017-02, Vol.53, p.57-72

2017

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The Antifolates

Hematology/oncology clinics of North America, 2012-06, Vol.26 (3), p.629-648

2012

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A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation

The Journal of biological chemistry, 2020-11, Vol.295 (46), p.15650-15661

2020

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Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

Cell, 2006-12, Vol.127 (5), p.917-928

2006

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Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

Molecular cancer therapeutics, 2007-02, Vol.6 (2), p.404-417

2007

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The proton-coupled folate transporter: physiological and pharmacological roles

Current opinion in pharmacology, 2013-12, Vol.13 (6), p.875-880

2013

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Schedule-Dependent Cytotoxic Synergism of Pemetrexed and Erlotinib in Human Non–Small Cell Lung Cancer Cells

Clinical cancer research, 2007-06, Vol.13 (11), p.3413-3422

2007

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Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation

American Journal of Physiology: Cell Physiology, 2017-04, Vol.312 (4), p.C517-C526

2017

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Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)

American Journal of Physiology: Cell Physiology, 2012-09, Vol.303 (6), p.C673-C681

2012

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Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1)

American Journal of Physiology: Cell Physiology, 2015-04, Vol.308 (8), p.C631-C641

2015

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Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

Biochimica et biophysica acta. Biomembranes, 2017-11, Vol.1859 (11), p.2193-2202

2017

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A Role for the Proton-coupled Folate Transporter (PCFT-SLC46A1) in Folate Receptor-mediated Endocytosis

The Journal of biological chemistry, 2009-02, Vol.284 (7), p.4267-4274

2009

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Resistance to antifolates

Oncogene, 2003-10, Vol.22 (47), p.7431-7457

2003

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Membrane Topological Analysis of the Proton-Coupled Folate Transporter (PCFT-SLC46A1) by the Substituted Cysteine Accessibility Method

Biochemistry (Easton), 2010-04, Vol.49 (13), p.2925-2931

2010

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Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking

The Journal of biological chemistry, 2016-04, Vol.291 (15), p.8162-8172

2016

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The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

Molecular pharmacology, 2008-09, Vol.74 (3), p.854-862

2008

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A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding

American Journal of Physiology: Cell Physiology, 2012-05, Vol.302 (9), p.C1405-C1412

2012

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Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption

American Journal of Physiology: Cell Physiology, 2012-10, Vol.303 (8), p.C834-C842

2012

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Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method

American Journal of Physiology: Cell Physiology, 2013-06, Vol.304 (12), p.C1159-C1167

2013

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Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction

American Journal of Physiology: Cell Physiology, 2007-11, Vol.293 (5), p.C1669-C1678

2007

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Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

Blood, 2010-12, Vol.116 (24), p.5162-5169

2010

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Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1

American Journal of Physiology: Cell Physiology, 2009-07, Vol.297 (1), p.C66-C74

2009

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Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1)

Molecular pharmacology, 2012-02, Vol.81 (2), p.134-142

2012

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Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors

The intestinal absorption of folates

The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption

The Antifolates

A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation

Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications

The proton-coupled folate transporter: physiological and pharmacological roles

Schedule-Dependent Cytotoxic Synergism of Pemetrexed and Erlotinib in Human Non–Small Cell Lung Cancer Cells

Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation

Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)

Identification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1)

Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

A Role for the Proton-coupled Folate Transporter (PCFT-SLC46A1) in Folate Receptor-mediated Endocytosis

Resistance to antifolates

Membrane Topological Analysis of the Proton-Coupled Folate Transporter (PCFT-SLC46A1) by the Substituted Cysteine Accessibility Method

Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

A P425R mutation of the proton-coupled folate transporter causing hereditary folate malabsorption produces a highly selective alteration in folate binding

Functional roles of the A335 and G338 residues of the proton-coupled folate transporter (PCFT-SLC46A1) mutated in hereditary folate malabsorption

Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1

Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1)

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