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SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies

Clinical cancer research, 2014-09, Vol.20 (17), p.4574-4583

2014

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Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (8), p.4426-4433

2006

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Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

Journal of medicinal chemistry, 2011-05, Vol.54 (10), p.3606-3623

2011

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Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

Cancer research (Chicago, Ill.), 2010-03, Vol.70 (6), p.2528-2537

2010

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High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction

PloS one, 2015-02, Vol.10 (2), p.e0117523-e0117523

2015

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Cytomegalovirus Cell Death Suppressor vMIA Blocks Bax- but Not Bak-Mediated Apoptosis by Binding and Sequestering Bax at Mitochondria

Proceedings of the National Academy of Sciences - PNAS, 2004-05, Vol.101 (21), p.7988-7993

2004

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Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses

Virology (New York, N.Y.), 2003-11, Vol.316 (2), p.221-233

2003

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A clinically relevant SCID-hu in vivo model of human multiple myeloma

Blood, 2005-07, Vol.106 (2), p.713-716

2005

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Cytopathic Effects of the Cytomegalovirus-Encoded Apoptosis Inhibitory Protein vMIA

Cell biology international, 2006-09, Vol.174 (7), p.985-996

2006

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A Cytomegalovirus-Encoded Mitochondria-Localized Inhibitor of Apoptosis Structurally Unrelated to Bcl-2

Proceedings of the National Academy of Sciences - PNAS, 1999-10, Vol.96 (22), p.12536-12541

1999

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Cytotoxic activity of the maytansinoid immunoconjugate B-B4–DM1 against CD138+ multiple myeloma cells

Blood, 2004-12, Vol.104 (12), p.3688-3696

2004

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murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization

Apoptosis (London), 2008-09, Vol.13 (9), p.1100-1110

2008

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IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors

Molecular cancer therapeutics, 2015-07, Vol.14 (7), p.1605-1613

2015

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An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria

The Journal of biological chemistry, 2004-05, Vol.279 (21), p.22605-22614

2004

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Cell killing by antibody–drug conjugates

Cancer letters, 2007-10, Vol.255 (2), p.232-240

2007

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Statistics of the Distribution of the Abundance of Molecules with Various Drug Loads in Maytansinoid Antibody–Drug Conjugates

Molecular pharmaceutics, 2015-06, Vol.12 (6), p.1738-1744

2015

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A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells

Blood advances, 2018-04, Vol.2 (8), p.848-858

2018

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Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation

Journal of Virology, 2006-07, Vol.80 (14), p.6771-6783

2006

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Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen

Cancer research (Chicago, Ill.), 2006-03, Vol.66 (6), p.3214-3221

2006

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Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer

Journal of medicinal chemistry, 2006-07, Vol.49 (14), p.4392-4408

2006

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Synthesis and Biological Evaluation of Antibody Conjugates of Phosphate Prodrugs of Cytotoxic DNA Alkylators for the Targeted Treatment of Cancer

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.766-782

2012

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Antibody-drug conjugates: using monoclonal antibodies for delivery of cytotoxic payloads to cancer cells

Therapeutic delivery, 2011-03, Vol.2 (3), p.397-416

2011

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The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets

EMBO molecular medicine, 2013-01, Vol.5 (1), p.18-37

2013

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A Cytomegalovirus-Encoded Inhibitor of Apoptosis That Suppresses Caspase-8 Activation

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (14), p.7829-7834

2001

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Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5885-5888

2004

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SAR650984, A Novel Humanized CD38-Targeting Antibody, Demonstrates Potent Antitumor Activity in Models of Multiple Myeloma and Other CD38+ Hematologic Malignancies

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing

Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction

Cytomegalovirus Cell Death Suppressor vMIA Blocks Bax- but Not Bak-Mediated Apoptosis by Binding and Sequestering Bax at Mitochondria

Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses

A clinically relevant SCID-hu in vivo model of human multiple myeloma

Cytopathic Effects of the Cytomegalovirus-Encoded Apoptosis Inhibitory Protein vMIA

A Cytomegalovirus-Encoded Mitochondria-Localized Inhibitor of Apoptosis Structurally Unrelated to Bcl-2

Cytotoxic activity of the maytansinoid immunoconjugate B-B4–DM1 against CD138+ multiple myeloma cells

murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization

IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors

An Anti-apoptotic Viral Protein That Recruits Bax to Mitochondria

Cell killing by antibody–drug conjugates

Statistics of the Distribution of the Abundance of Molecules with Various Drug Loads in Maytansinoid Antibody–Drug Conjugates

A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells

Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation

Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen

Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer

Synthesis and Biological Evaluation of Antibody Conjugates of Phosphate Prodrugs of Cytotoxic DNA Alkylators for the Targeted Treatment of Cancer

Antibody-drug conjugates: using monoclonal antibodies for delivery of cytotoxic payloads to cancer cells

The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets

A Cytomegalovirus-Encoded Inhibitor of Apoptosis That Suppresses Caspase-8 Activation

Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors

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