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Acid-Mediated Ring Expansion of 2,2-Disubstituted Azetidine Carbamates to 6,6-Disubstituted 1,3-Oxazinan-2-ones

Organic letters, 2019-03, Vol.21 (6), p.1818-1822

2019

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A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides

Tetrahedron letters, 2014-08, Vol.55 (32), p.4433-4436

2014

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The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

European journal of medicinal chemistry, 2016-04, Vol.112, p.20-32

2016

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Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5361-5379

2012

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Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390

Journal of medicinal chemistry, 2024-02, Vol.67 (4), p.3090-3111

2024

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Sustainable Practices in Medicinal Chemistry Part 2: Green by Design

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5955-5968

2017

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Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

Journal of medicinal chemistry, 2021-09, Vol.64 (18), p.13524-13539

2021

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Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy

Journal of medicinal chemistry, 2021-03, Vol.64 (6), p.3165-3184

2021

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Discovery of a Series of 3‑Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

ACS medicinal chemistry letters, 2018-08, Vol.9 (8), p.809-814

2018

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Sustainable Practices in Medicinal Chemistry Part 2: Green by Design: Miniperspective

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5955-5968

2017

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Abstract 778: The identification and structure-guided optimisation of potent and selective inhibitors of oncogenes in medullary thyroid carcinoma and lung adenocarcinoma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.778-778

2015

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Oxadiazole isomers: all bioisosteres are not created equal

MedChemComm, 2012-05, Vol.3 (5), p.600

2012

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Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7310-7316

2011

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Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors

MedChemComm, 2013, Vol.4 (9), p.1305

2013

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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

MedChemComm, 2013, Vol.4 (1), p.95-100

2013

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Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00156c

2013-08

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Oxadiazole isomers: all bioisosteres are not created equalElectronic supplementary information (ESI) available: Complete synthetic details for the preparation of compounds 1 to 7. CCDC reference numbers 854369 and 854370. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2md20054f

2012-05

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Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonistsThis article is part of a MedChemComm 'New Talents' issue highlighting the work of outstanding rising scientists in medicinal chemistry research.Electronic supplementary information (ESI) available: Synthetic details for the synthesis of 11 and crystallographic data for 13. See DOI: 10.1039/c2md20130e

2012-12

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ChemInform Abstract: A Facile Synthesis of 3-Trifluoromethyl-1,2,4-oxadiazoles from Cyanamides

ChemInform, 2015-01, Vol.46 (2), p.no-no

2015

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A high-resolution record of early Paleozoic climate

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (6)

2021

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Transplant-Free Survival and Interventions at 6 Years in the SVR Trial

Circulation (New York, N.Y.), 2018-05, Vol.137 (21), p.2246-2253

2018

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Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure

Journal of the American College of Cardiology, 2017-06, Vol.69 (22), p.2735-2744

2017

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Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

Cancer research (Chicago, Ill.), 2020-05, Vol.80 (10), p.2017-2030

2020

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Longitudinal trajectories of adult sibling relationship quality and psychological well‐being: The effect of childhood maltreatment

Family relations, 2024-04, Vol.73 (2), p.891-904

2024

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Acid-Mediated Ring Expansion of 2,2-Disubstituted Azetidine Carbamates to 6,6-Disubstituted 1,3-Oxazinan-2-ones

A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides

The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity

Use of Small-Molecule Crystal Structures To Address Solubility in a Novel Series of G Protein Coupled Receptor 119 Agonists: Optimization of a Lead and in Vivo Evaluation

Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390

Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

Sustainable Practices in Medicinal Chemistry Part 2: Green by Design

Optimization of an Imidazo[1,2‑a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy

Discovery of a Series of 3‑Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

Sustainable Practices in Medicinal Chemistry Part 2: Green by Design: Miniperspective

Abstract 778: The identification and structure-guided optimisation of potent and selective inhibitors of oncogenes in medullary thyroid carcinoma and lung adenocarcinoma

Oxadiazole isomers: all bioisosteres are not created equal

Discovery, optimisation and in vivo evaluation of novel GPR119 agonists

Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors

Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists

Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/c3md00156c

ChemInform Abstract: A Facile Synthesis of 3-Trifluoromethyl-1,2,4-oxadiazoles from Cyanamides

A high-resolution record of early Paleozoic climate

Transplant-Free Survival and Interventions at 6 Years in the SVR Trial

Longitudinal Outcomes of Patients With Single Ventricle After the Fontan Procedure

Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations

Longitudinal trajectories of adult sibling relationship quality and psychological well‐being: The effect of childhood maltreatment

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