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Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (3), p.413-419

2017

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Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension

The Journal of pharmacology and experimental therapeutics, 2017-02, Vol.360 (2), p.267

2017

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Acrylonitrile Cross-Metathesis: Coaxing Olefin Metathesis Reactivity from a Reluctant Substrate

Journal of the American Chemical Society, 1995-05, Vol.117 (18), p.5162-5163

1995

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Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1124-1129

2016

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Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2016-06, Vol.26 (12), p.2855-2860

2016

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Positive Cooperativity of Product Mimics in the Asymmetric Autoinduction of Diels−Alder Reactions Catalyzed by a VAPOL−Aluminum Catalyst

Journal of the American Chemical Society, 1997-10, Vol.119 (43), p.10551-10552

1997

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Synthesis and SAR studies of indole-based MK2 inhibitors

Bioorganic & medicinal chemistry, 2008-03, Vol.18 (6), p.1994-1999

2008

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The discovery of carboline analogs as potent MAPKAP-K2 inhibitors

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4664-4669

2007

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Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Journal of medicinal chemistry, 2007-08, Vol.50 (17), p.4016-4026

2007

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Discovery and characterization of the N-phenyl- N′-naphthylurea class of p38 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2386-2391

2009

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Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors: 1H-Imidazo[1,2-α]imidazol-2-one Derivatives

Journal of medicinal chemistry, 2004-10, Vol.47 (22), p.5356-5366

2004

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Discovery and SAR of novel [1,6]Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK)

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (8), p.1415-1418

2003

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Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally Active Inhibitors of lck Kinase

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1337-1349

2003

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Preparation of allylsilanes via cross-metathesis

Tetrahedron letters, 1996-03, Vol.37 (13), p.2117-2120

1996

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The first synthesis of cyclopropanone acetals from the reaction of Fischer carbene complexes with ketene acetals

Journal of organometallic chemistry, 2005-12, Vol.690 (24), p.6101-6110

2005

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Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors: 1 H -Imidazo[1,2-α]imidazol-2-one Derivatives

Journal of medicinal chemistry, 2004-10, Vol.47 (22), p.5356-5366

2004

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The tandem intramolecular Diels-Alder reaction

Tetrahedron letters, 1993-12, Vol.34 (50), p.8003-8006

1993

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An Examination of VANOL, VAPOL, and VAPOL Derivatives as Ligands for Asymmetric Catalytic Diels-Alder Reactions

ChemInform, 2007-05, Vol.38 (20), p.no-no

2007

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The First Synthesis of Cyclopropanone Acetals from the Reaction of Fischer Carbene Complexes with Ketene Acetals

ChemInform, 2006-07, Vol.37 (29), p.no-no

2006

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Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

Cell, 2012-03, Vol.148 (6), p.1271-1283

2012

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CdrA Interactions within the Pseudomonas aeruginosa Biofilm Matrix Safeguard It from Proteolysis and Promote Cellular Packing

mBio, 2018-09, Vol.9 (5)

2018

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A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity

mBio, 2019-03, Vol.10 (2)

2019

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LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

mBio, 2016-10, Vol.7 (5)

2016

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PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

Nature (London), 2014-07, Vol.511 (7511), p.592-595

2014

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Malaria parasite translocon structure and mechanism of effector export

Nature (London), 2018-09, Vol.561 (7721), p.70-75

2018

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Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors

Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension

Acrylonitrile Cross-Metathesis: Coaxing Olefin Metathesis Reactivity from a Reluctant Substrate

Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors

Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors

Positive Cooperativity of Product Mimics in the Asymmetric Autoinduction of Diels−Alder Reactions Catalyzed by a VAPOL−Aluminum Catalyst

Synthesis and SAR studies of indole-based MK2 inhibitors

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors

Discovery and Optimization of p38 Inhibitors via Computer-Assisted Drug Design

Discovery and characterization of the N-phenyl- N′-naphthylurea class of p38 kinase inhibitors

Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors: 1H-Imidazo[1,2-α]imidazol-2-one Derivatives

Discovery and SAR of novel [1,6]Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK)

Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally Active Inhibitors of lck Kinase

Preparation of allylsilanes via cross-metathesis

The first synthesis of cyclopropanone acetals from the reaction of Fischer carbene complexes with ketene acetals

Second-Generation Lymphocyte Function-Associated Antigen-1 Inhibitors: 1 H -Imidazo[1,2-α]imidazol-2-one Derivatives

The tandem intramolecular Diels-Alder reaction

An Examination of VANOL, VAPOL, and VAPOL Derivatives as Ligands for Asymmetric Catalytic Diels-Alder Reactions

The First Synthesis of Cyclopropanone Acetals from the Reaction of Fischer Carbene Complexes with Ketene Acetals

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

CdrA Interactions within the Pseudomonas aeruginosa Biofilm Matrix Safeguard It from Proteolysis and Promote Cellular Packing

A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

Malaria parasite translocon structure and mechanism of effector export

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