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The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development
Pharmacology, biochemistry and behavior, 2020-09, Vol.196, p.172996-172996, Article 172996
2020
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The α2,3-selective potentiator of GABA A receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats
Pharmacology, biochemistry and behavior, 2019-05, Vol.180, p.22
2019
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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA A receptors
Pharmacology, biochemistry and behavior, 2018-07, Vol.170, p.9-13
2018
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The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats
Pharmacology, biochemistry and behavior, 2019-05, Vol.180, p.22-31
2019
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An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors
Pharmacology, biochemistry and behavior, 2018-07, Vol.170, p.9-13
2018
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GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Pharmacology & therapeutics (Oxford), 2022-06, Vol.234, p.108035-108035, Article 108035
2022
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(R)-(-)-Ketamine: The Promise of a Novel Treatment for Psychiatric and Neurological Disorders
International journal of molecular sciences, 2024-06, Vol.25 (12), p.6804
2024
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Lymphatic vessels arise from specialized angioblasts within a venous niche
Nature (London), 2015-06, Vol.522 (7554), p.56-61
2015
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Clinical pharmacological innovation in the treatment of depression
Expert review of clinical pharmacology, 2023-04, Vol.16 (4), p.349-362
2023
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The Positive Allosteric Modulator of α 2/3-Containing GABA A Receptors, KRM-II-81, Is Active in Pharmaco-Resistant Models of Epilepsy and Reduces Hyperexcitability after Traumatic Brain Injury
The Journal of pharmacology and experimental therapeutics, 2020-01, Vol.372 (1), p.83
2020
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Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation
The Journal of pharmacology and experimental therapeutics, 2023-04, Vol.385 (1), p.50
2023
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Rapid-acting antidepressants
Advances in pharmacology (1990), 2019, Vol.86, p.47-96
2019
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New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4 H -benzo[ f ]imidazo[1,5- a ][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy
ACS chemical neuroscience, 2024-02, Vol.15 (3), p.517
2024
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Comparative anticonvulsant activity of the GABAkine KRM‐II‐81 and a deuterated analog
Drug development research, 2023-05, Vol.84 (3), p.527-531
2023
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Understanding 3D anisotropic reactive ion etching of oxide-metal stacks
Journal of vacuum science and technology. B, Nanotechnology & microelectronics, 2023-12, Vol.41 (6)
2023
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Effect of Covid-19 pandemic on cost of healthcare following suicide attempts
The American journal of the medical sciences, 2023-02, Vol.365, p.S95-S96
2023
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180 - Effect of Covid-19 pandemic on cost of healthcare following suicide attempts
The American journal of the medical sciences, 2023-02, Vol.365, p.S95-S96
2023
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Hydrochloride Salt of the GABAkine KRM-II-81
ACS omega, 2022-08, Vol.7 (31), p.27550-27559
2022
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New Imidazodiazepine Analogue, 5‑(8-Bromo-6-(pyridin-2-yl)‑4H‑benzo[f]imidazo[1,5‑a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy
ACS chemical neuroscience, 2024-02, Vol.15 (3), p.517-526
2024
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Imidazodiazepine Anticonvulsant, KRM-II-81, Produces Novel, Non-diazepam-like Antiseizure Effects
ACS chemical neuroscience, 2020-09, Vol.11 (17), p.2624-2637
2020
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GABAkines – Advances in the Discovery, Development, and Commercialization of Positive Allosteric Modulators of GABAA Receptors1
Pharmacology & therapeutics (Oxford), 2021-11, Vol.234, p.108035-108035
2021
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Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3‐selective GABAkine KRM‐II‐81
Biopharmaceutics & drug disposition, 2022-04, Vol.43 (2), p.66-75
2022
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The Positive Allosteric Modulator of Alpha-2/3-Containing γ-Aminobutyric Acid Type A Receptors, KRM-II-81, Is Active in Pharmacoresistant Models of Epilepsy and in Human Epileptic Tissue
Neurosurgery, 2019-09, Vol.66 (Supplement 1), p.310-697
2019
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GABAkines - Advances in the discovery, development, and commercialization of positive allosteric modulators of GABA A receptors
Pharmacology & therapeutics (Oxford), 2022-06, Vol.234, p.108035
2022
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Involvement of muscarinic receptor mechanisms in antidepressant drug action
Advances in pharmacology (1990), 2020, Vol.89, p.311-356
2020
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