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Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

Biophysical journal, 2012-07, Vol.103 (1), p.69-78

2012

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Particle shape enhances specificity of antibody-displaying nanoparticles

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (9), p.3270-3275

2013

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Designing Robust Monoclonal Antibody Drug Products: Pitfalls of Simplistic Approaches for Stability Prediction

Journal of pharmaceutical sciences, 2024-08, Vol.113 (8), p.2296-2304

2024

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A scaling relationship between thermodynamic and hydrodynamic interactions in protein solutions

Biophysical journal, 2024-10

2024

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A single molecular descriptor to predict solution behavior of therapeutic antibodies

Science advances, 2020-08, Vol.6 (32), p.eabb0372

2020

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Analytical methods for physicochemical characterization of antibody drug conjugates

mAbs, 2011-03, Vol.3 (2), p.161-172

2011

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Characterization of Opalescence in low Volume Monoclonal Antibody Solutions Enabled by Microscale Nephelometry

Journal of pharmaceutical sciences, 2021-09, Vol.110 (9), p.3176-3182

2021

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Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

Biophysical journal, 2010-10, Vol.99 (8), p.2657-2665

2010

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Ultradilute Measurements of Self-Association for the Identification of Antibodies with Favorable High-Concentration Solution Properties

Molecular pharmaceutics, 2021-07, Vol.18 (7), p.2744-2753

2021

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Machine Learning Feature Selection for Predicting High Concentration Therapeutic Antibody Aggregation

Journal of pharmaceutical sciences, 2021-04, Vol.110 (4), p.1583-1591

2021

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Effect of PEGylation on Protein Hydrodynamics

Molecular pharmaceutics, 2012-04, Vol.9 (4), p.762-773

2012

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Characterization of antibody aggregation: Role of buried, unpaired cysteines in particle formation

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.764-781

2010

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Small-Angle Neutron Scattering Characterization of Monoclonal Antibody Conformations and Interactions at High Concentrations

Biophysical journal, 2013-08, Vol.105 (3), p.720-731

2013

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Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions

Protein science, 2011-03, Vol.20 (3), p.580-587

2011

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Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

Pharmaceutical research, 2009-04, Vol.26 (4), p.903-913

2009

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A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans

PNAS nexus, 2023-10, Vol.2 (10), p.pgad317-pgad317

2023

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Non-invasive delivery strategies for biologics

Nature reviews. Drug discovery, 2019-01, Vol.18 (1), p.19-40

2019

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Polar Solvents Decrease the Viscosity of High Concentration IgG1 Solutions Through Hydrophobic Solvation and Interaction: Formulation and Biocompatibility Considerations

Journal of pharmaceutical sciences, 2013-04, Vol.102 (4), p.1182-1193

2013

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Ion‐specific modulation of protein interactions: Anion‐induced, reversible oligomerization of a fusion protein

Protein science, 2009-01, Vol.18 (1), p.169-179

2009

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Self-Buffering Antibody Formulations

Journal of pharmaceutical sciences, 2008-08, Vol.97 (8), p.3051-3066

2008

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Anion Binding Mediated Precipitation of a Peptibody

Pharmaceutical research, 2009, Vol.26 (1), p.152-160, Article 152

2009

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Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies

Molecular pharmaceutics, 2021-03, Vol.18 (3), p.1167-1175

2021

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Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs

Drug development research, 2020-05, Vol.81 (3), p.329-337

2020

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Preformulation of New Biological Entities

Parenteral Medications, 2019, p.69-91

4, 2019

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Assessment and significance of protein–protein interactions during development of protein biopharmaceuticals

Biophysical reviews, 2013-06, Vol.5 (2), p.121-136

2013

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Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

Particle shape enhances specificity of antibody-displaying nanoparticles

Designing Robust Monoclonal Antibody Drug Products: Pitfalls of Simplistic Approaches for Stability Prediction

A scaling relationship between thermodynamic and hydrodynamic interactions in protein solutions

A single molecular descriptor to predict solution behavior of therapeutic antibodies

Analytical methods for physicochemical characterization of antibody drug conjugates

Characterization of Opalescence in low Volume Monoclonal Antibody Solutions Enabled by Microscale Nephelometry

Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

Ultradilute Measurements of Self-Association for the Identification of Antibodies with Favorable High-Concentration Solution Properties

Machine Learning Feature Selection for Predicting High Concentration Therapeutic Antibody Aggregation

Effect of PEGylation on Protein Hydrodynamics

Characterization of antibody aggregation: Role of buried, unpaired cysteines in particle formation

Small-Angle Neutron Scattering Characterization of Monoclonal Antibody Conformations and Interactions at High Concentrations

Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions

Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans

Non-invasive delivery strategies for biologics

Polar Solvents Decrease the Viscosity of High Concentration IgG1 Solutions Through Hydrophobic Solvation and Interaction: Formulation and Biocompatibility Considerations

Ion‐specific modulation of protein interactions: Anion‐induced, reversible oligomerization of a fusion protein

Self-Buffering Antibody Formulations

Anion Binding Mediated Precipitation of a Peptibody

Machine Learning Applied to Determine the Molecular Descriptors Responsible for the Viscosity Behavior of Concentrated Therapeutic Antibodies

Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs

Preformulation of New Biological Entities

Assessment and significance of protein–protein interactions during development of protein biopharmaceuticals

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