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Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

The Journal of biological chemistry, 2015-02, Vol.290 (8), p.4573-4589

2015

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ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation

Modern rheumatology, 2019-05, Vol.29 (3), p.510-522

2019

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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Scientific reports, 2022-08, Vol.12 (1), p.14561-14561, Article 14561

2022

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Analysis of the role of PCNA-DNA contacts during clamp loading

BMC structural biology, 2010-01, Vol.10 (1), p.3-3, Article 3

2010

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DNA polymerase clamp loaders and DNA recognition

FEBS letters, 2005-02, Vol.579 (4), p.863-867

2005

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ACT1 Is Required for Murine IL-23–Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity

Journal of investigative dermatology, 2021-07, Vol.141 (7), p.1772-1779.e6

2021

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Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

Journal of medicinal chemistry, 2024-04, Vol.67 (8), p.6456-6494

2024

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Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis

Journal of dermatology, 2023-10, Vol.50 (10), p.1321-1329

2023

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The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

Cell, 2009-05, Vol.137 (4), p.659-671

2009

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Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses

ACS chemical biology, 2019-05, Vol.14 (5), p.857-872

2019

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Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase

SLAS discovery, 2018-12, Vol.23 (10), p.1040-1050

2018

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Domain-level stability of an antibody monitored by reduction, differential alkylation, and mass spectrometry analysis

Analytical biochemistry, 2010-05, Vol.400 (2), p.244-250

2010

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Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

ACS chemical biology, 2011-03, Vol.6 (3), p.234-244

2011

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HTRF-based assay for microsomal prostaglandin E2 synthase-1 activity

Journal of biomolecular screening, 2008-08, Vol.13 (7), p.619-625

2008

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Co-crystal of Escherichia coli RNase HI with Mn2+ Ions Reveals Two Divalent Metals Bound in the Active Site

The Journal of biological chemistry, 2001-03, Vol.276 (10), p.7266-7271

2001

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Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex

Nature structural & molecular biology, 2005-02, Vol.12 (2), p.183-190

2005

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Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

BMC structural biology, 2012-09, Vol.12 (1), p.22-22

2012

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Minimum significant ratio of selectivity ratios (MSRSR) and confidence in ratio of selectivity ratios (CRSR): quantitative measures for selectivity ratios obtained by screening assays

Journal of biomolecular screening, 2012-08, Vol.17 (7), p.857-867

2012

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Metal binding and activation of the ribonuclease H domain from Moloney murine leukemia virus

Protein engineering, 1999-11, Vol.12 (11), p.975-980

1999

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Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage

Protein expression and purification, 2011, Vol.75 (1), p.55-62

2011

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Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

BMC structural biology, 2006-01, Vol.6 (1), p.2-2, Article 2

2006

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Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding

Journal of molecular biology, 2004-03, Vol.336 (5), p.1047-1059

2004

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Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension

Proteins, structure, function, and bioinformatics, 1998-10, Vol.33 (1), p.135-143

1998

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Importance of the C-Terminal Helix to the Stability and Enzymatic Activity of Escherichia coli Ribonuclease H

Biochemistry (Easton), 1997-06, Vol.36 (23), p.7256-7263

1997

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Activation/Attenuation Model for RNase H

The Journal of biological chemistry, 1998-12, Vol.273 (51), p.34128-34133

1998

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Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

ABBV-105, a selective and irreversible inhibitor of Bruton's tyrosine kinase, is efficacious in multiple preclinical models of inflammation

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site

Analysis of the role of PCNA-DNA contacts during clamp loading

DNA polymerase clamp loaders and DNA recognition

ACT1 Is Required for Murine IL-23–Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity

Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

Importance of PLD2 in an IL-23 driven psoriasiform dermatitis model and potential link to human psoriasis

The Mechanism of ATP-Dependent Primer-Template Recognition by a Clamp Loader Complex

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses

Merits and Pitfalls in the Characterization of Covalent Inhibitors of Bruton’s Tyrosine Kinase

Domain-level stability of an antibody monitored by reduction, differential alkylation, and mass spectrometry analysis

Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases

HTRF-based assay for microsomal prostaglandin E2 synthase-1 activity

Co-crystal of Escherichia coli RNase HI with Mn2+ Ions Reveals Two Divalent Metals Bound in the Active Site

Mapping the interaction of DNA with the Escherichia coli DNA polymerase clamp loader complex

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Minimum significant ratio of selectivity ratios (MSRSR) and confidence in ratio of selectivity ratios (CRSR): quantitative measures for selectivity ratios obtained by screening assays

Metal binding and activation of the ribonuclease H domain from Moloney murine leukemia virus

Functional comparison of recombinant acidic mammalian chitinase with enzyme from murine bronchoalveolar lavage

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium

Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding

Folding the ribonuclease H domain of Moloney murine leukemia virus reverse transcriptase requires metal binding or a short N-terminal extension

Importance of the C-Terminal Helix to the Stability and Enzymatic Activity of Escherichia coli Ribonuclease H

Activation/Attenuation Model for RNase H

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