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Extreme Drug Tolerance of Mycobacterium abscessus "Persisters"

Frontiers in microbiology, 2020-03, Vol.11, p.359-359

2020

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Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure–Activity Relationships and Membrane Targeting Properties

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2745-2763

2017

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Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications

Molecular neurobiology, 2021-01, Vol.58 (1), p.106-117

2021

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Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria

RSC medicinal chemistry, 2022-12, Vol.13 (12), p.1605-1613

2022

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Antiproliferative, DNA intercalation and redox cycling activities of dioxonaphtho[2,3-d]imidazolium analogs of YM155: A structure–activity relationship study

European journal of medicinal chemistry, 2015-11, Vol.104, p.42-56

2015

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Synthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.5904-5918

2014

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Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein

Bioorganic & medicinal chemistry, 2008, Vol.16 (1), p.171-180

2008

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Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study

PloS one, 2015-04, Vol.10 (4), p.e0124673-e0124673

2015

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Synthesis and evaluation of functionalized isoindigos as antiproliferative agents

Bioorganic & medicinal chemistry, 2009-11, Vol.17 (21), p.7562-7571

2009

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Functionalized 3-benzylidene-indolin-2-ones: Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (5), p.2077-2090

2009

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N′-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

ChemMedChem, 2015-09, Vol.10 (9), p.1548-1558

2015

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Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5733-5750

2018

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Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.15991-16007

2021

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PROTAC antibiotics: the time is now

Expert opinion on drug discovery, 2023-04, Vol.18 (4), p.363-370

2023

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Dioxonaphthoimidazoliums are Potent and Selective Rogue Stem Cell Clearing Agents with SOX2-Suppressing Properties

ChemMedChem, 2016-09, Vol.11 (17), p.1944-1955

2016

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Novel antiplasmodial agents

Medicinal research reviews, 2003-07, Vol.23 (4), p.456-487

Go, Mei-Lin

2003

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Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes

Antimicrobial Agents and Chemotherapy, 2004-09, Vol.48 (9), p.3241-3245

2004

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Curcumin Analogues with Potent and Selective Anti-proliferative Activity on Acute Promyelocytic Leukemia: Involvement of Accumulated Misfolded Nuclear Receptor Co-repressor (N-CoR) Protein as a Basis for Selective Activity

ChemMedChem, 2012-09, Vol.7 (9), p.1567-1579

2012

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Structure-activity relationships of antileishmanial and antimalarial chalcones

Bioorganic & medicinal chemistry, 2003-07, Vol.11 (13), p.2729-2738

2003

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Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis

Antimicrobial agents and chemotherapy, 2020-11, Vol.64 (12)

2020

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Rifabutin Suppresses Inducible Clarithromycin Resistance in Mycobacterium abscessus by Blocking Induction of whiB7 and erm41

Antibiotics (Basel), 2020-02, Vol.9 (2), p.72

2020

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Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR

European journal of medicinal chemistry, 2010-07, Vol.45 (7), p.2957-2971

2010

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Anti-survivin effect of the small molecule inhibitor YM155 in RCC cells is mediated by time-dependent inhibition of the NF-κB pathway

Scientific reports, 2018-07, Vol.8 (1), p.10289-10, Article 10289

2018

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Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells

European journal of medicinal chemistry, 2019-11, Vol.182, p.111597-111597, Article 111597

2019

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Amide–Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility

ACS medicinal chemistry letters, 2021-05, Vol.12 (5), p.704-712

2021

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Extreme Drug Tolerance of Mycobacterium abscessus "Persisters"

Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure–Activity Relationships and Membrane Targeting Properties

Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications

Alkyltriphenylphosphonium turns naphthoquinoneimidazoles into potent membrane depolarizers against mycobacteria

Antiproliferative, DNA intercalation and redox cycling activities of dioxonaphtho[2,3-d]imidazolium analogs of YM155: A structure–activity relationship study

Synthesis and evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in acute promyelocytic leukemic cells

Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein

Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study

Synthesis and evaluation of functionalized isoindigos as antiproliferative agents

Functionalized 3-benzylidene-indolin-2-ones: Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity

N′-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma

Indolyl Azaspiroketal Mannich Bases Are Potent Antimycobacterial Agents with Selective Membrane Permeabilizing Effects and in Vivo Activity

Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis

PROTAC antibiotics: the time is now

Dioxonaphthoimidazoliums are Potent and Selective Rogue Stem Cell Clearing Agents with SOX2-Suppressing Properties

Novel antiplasmodial agents

Antiplasmodial Chalcones Inhibit Sorbitol-Induced Hemolysis of Plasmodium falciparum-Infected Erythrocytes

Curcumin Analogues with Potent and Selective Anti-proliferative Activity on Acute Promyelocytic Leukemia: Involvement of Accumulated Misfolded Nuclear Receptor Co-repressor (N-CoR) Protein as a Basis for Selective Activity

Structure-activity relationships of antileishmanial and antimalarial chalcones

Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis

Rifabutin Suppresses Inducible Clarithromycin Resistance in Mycobacterium abscessus by Blocking Induction of whiB7 and erm41

Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR

Anti-survivin effect of the small molecule inhibitor YM155 in RCC cells is mediated by time-dependent inhibition of the NF-κB pathway

Galloyl esters of trans-stilbenes are inhibitors of FASN with anticancer activity on non-small cell lung cancer cells

Amide–Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility

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