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Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

Archives of toxicology, 2014-07, Vol.88 (7), p.1427-1437

2014

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A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat

Biomarkers, 2017-07, Vol.22 (5), p.461-469

2017

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hERG-Toxicity Prediction using Traditional Machine Learning and Advanced Deep Learning Techniques

Current research in toxicology, 2023-01, Vol.5, p.100121-100121, Article 100121

2023

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The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels

International journal of molecular medicine, 2016-09, Vol.38 (3), p.961-968

2016

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Isoforms of alanine aminotransferases in human tissues and serum—Differential tissue expression using novel antibodies

Archives of biochemistry and biophysics, 2007-10, Vol.466 (1), p.66-77

2007

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Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans

International journal of molecular medicine, 2012-11, Vol.30 (5), p.1241-1249

2012

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PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

Toxicology and applied pharmacology, 2008-08, Vol.231 (1), p.1-9

2008

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The regulatory role of PGC1α‐related coactivator in response to drug‐induced liver injury

FASEB bioAdvances, 2020-08, Vol.2 (8), p.453-463

2020

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Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

Liver international, 2014-03, Vol.34 (3), p.367-378

2014

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A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

Biomarkers, 2009-12, Vol.14 (8), p.572-586

2009

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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Journal of medicinal chemistry, 2023-01, Vol.66 (2), p.1380-1425

2023

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New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.3968-3994

2023

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Proliferative and Molecular Effects of the Dual PPARα/γ Agonist Tesaglitazar in Rat Adipose Tissues: Relevance for Induction of Fibrosarcoma

Toxicologic pathology, 2011-02, Vol.39 (2), p.325-336

2011

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Effect of Colonic Luminal Components on Induction of Apoptosis in Human Colonic Cell Lines

Nutrition and cancer, 2000-01, Vol.36 (1), p.79-89

2000

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Recent Advances in Deriving Hepatocyte Like Cells from Induced Pluripotent Stem Cells in Drug Metabolism and Toxicity Studies

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells

Gastroenterology (New York, N.Y. 1943), 2001-02, Vol.120 (2), p.401-410

2001

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Isoform specific ALT measurement during liver and skeletal muscle damage

Toxicology letters, 2012-06, Vol.211, p.S48-S48

2012

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Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma

International journal of molecular medicine, 2009-05, Vol.23 (5), p.621-631

2009

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Toxicity with LXR agonists – Problem solving activities for mechanistic understanding

Toxicology letters, 2012-06, Vol.211 (Suppl. (S)), p.S39-S39

2012

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Keratin‐18 and micro RNA ‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts

Liver international, 2014-03, Vol.34 (3), p.367-378

2014

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Qualification of new biomarkers for drug-induced liver injury in a human cohort

TOXICOLOGY LETTERS, 2012-06, Vol.211, p.S48-S48

2012

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PPARδ increases expression of the human apolipoprotein A-II gene in human liver cells

International journal of molecular medicine, 2008-06, Vol.21 (6), p.819-824

2008

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Proliferative and molecular effects of the dual PPARalpha/gamma agonist tesaglitazar in rat adipose tissues: relevance for induction of fibrosarcoma

Toxicologic pathology, 2011-02, Vol.39 (2), p.325-336

2011

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Differential expression of peroxisomal proliferator activated receptors α and δ in skeletal muscle in response to changes in diet and exercise

International journal of molecular medicine, 2006-01, Vol.17 (1), p.45-52

2006

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Isoform-specific alanine aminotransferase measurement candistinguish hepatic from extrahepatic injury in humans

International journal of molecular medicine, 2012, Vol.30, p.1241

2012

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Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat

hERG-Toxicity Prediction using Traditional Machine Learning and Advanced Deep Learning Techniques

The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels

Isoforms of alanine aminotransferases in human tissues and serum—Differential tissue expression using novel antibodies

Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans

PPARα regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

The regulatory role of PGC1α‐related coactivator in response to drug‐induced liver injury

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Proliferative and Molecular Effects of the Dual PPARα/γ Agonist Tesaglitazar in Rat Adipose Tissues: Relevance for Induction of Fibrosarcoma

Effect of Colonic Luminal Components on Induction of Apoptosis in Human Colonic Cell Lines

Recent Advances in Deriving Hepatocyte Like Cells from Induced Pluripotent Stem Cells in Drug Metabolism and Toxicity Studies

Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells

Isoform specific ALT measurement during liver and skeletal muscle damage

Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma

Toxicity with LXR agonists – Problem solving activities for mechanistic understanding

Keratin‐18 and micro RNA ‐122 complement alanine aminotransferase as novel safety biomarkers for drug‐induced liver injury in two human cohorts

Qualification of new biomarkers for drug-induced liver injury in a human cohort

PPARδ increases expression of the human apolipoprotein A-II gene in human liver cells

Proliferative and molecular effects of the dual PPARalpha/gamma agonist tesaglitazar in rat adipose tissues: relevance for induction of fibrosarcoma

Differential expression of peroxisomal proliferator activated receptors α and δ in skeletal muscle in response to changes in diet and exercise

Isoform-specific alanine aminotransferase measurement candistinguish hepatic from extrahepatic injury in humans

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