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The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells

Breast cancer research : BCR, 2018-03, Vol.20 (1), p.16-16, Article 16

2018

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Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

DNA repair, 2015-08, Vol.32, p.180-189

2015

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Impact of hypoxia on DNA repair and genome integrity

Mutagenesis, 2020-02, Vol.35 (1), p.61-68

2020

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Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

Cancer research (Chicago, Ill.), 2020-11, Vol.80 (21), p.4655-4667

2020

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MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

Cancer research (Chicago, Ill.), 2009-02, Vol.69 (3), p.1221-1229

2009

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Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

Science translational medicine, 2019-05, Vol.11 (492)

2019

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2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Science translational medicine, 2017-02, Vol.9 (375)

2017

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Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1

Molecular cancer research, 2018-10, Vol.16 (10), p.1458-1469

2018

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Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

Nature genetics, 2018-08, Vol.50 (8), p.1086-1092

2018

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Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery

International journal of molecular sciences, 2021-11, Vol.22 (23), p.12761

2021

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In utero nanoparticle delivery for site-specific genome editing

Nature communications, 2018-06, Vol.9 (1), p.2481-11, Article 2481

2018

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Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation

Nucleic acids research, 2022-06, Vol.50 (10), p.e59-e59

2022

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Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter

Molecular and Cellular Biology, 2011-08, Vol.31 (16), p.3339-3350

2011

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Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.632

2018

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Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

Molecules (Basel, Switzerland), 2020-02, Vol.25 (3), p.735

2020

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In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

Nature communications, 2016-10, Vol.7 (1), p.13304-14, Article 13304

2016

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Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1

Cell reports (Cambridge), 2014-07, Vol.8 (2), p.501-513

2014

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Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity

Journal of biochemistry (Tokyo), 2023-07, Vol.174 (2), p.183-191

2023

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Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides

Cells (Basel, Switzerland), 2021-03, Vol.10 (3), p.541

2021

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Interplay between DNA repair and inflammation, and the link to cancer

Critical reviews in biochemistry and molecular biology, 2014-03, Vol.49 (2), p.116-139

2014

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HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

Molecular cell, 2014-07, Vol.55 (1), p.31-46

2014

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Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (5), p.2201-2206

2010

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Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

Cancer research (Chicago, Ill.), 2008-01, Vol.68 (2), p.605-614

2008

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The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA

Nature chemistry, 2014-06, Vol.6 (6), p.504-510

2014

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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302

Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.740-751

2012

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The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells

Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

Impact of hypoxia on DNA repair and genome integrity

Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

MicroRNA Regulation of DNA Repair Gene Expression in Hypoxic Stress

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1

Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair

Regulation of the Cell-Intrinsic DNA Damage Response by the Innate Immune Machinery

In utero nanoparticle delivery for site-specific genome editing

Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation

Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter

Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing

Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1

Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity

Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides

Interplay between DNA repair and inflammation, and the link to cancer

HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSα

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130

Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA

Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302

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