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Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

Journal of the American Chemical Society, 2012-05, Vol.134 (20), p.8324-8327

2012

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Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features

Inorganic chemistry, 2020-01, Vol.59 (2), p.1006-1013

2020

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Ru(II) photocages enable precise control over enzyme activity with red light

Nature communications, 2022-06, Vol.13 (1), p.3636-3636, Article 3636

2022

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Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Chemical communications (Cambridge, England), 2012-01, Vol.48 (77), p.9649-9651

2012

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Coordination of Hydroxyquinolines to a Ruthenium Bis-dimethyl-phenanthroline Scaffold Radically Improves Potency for Potential as Antineoplastic Agents

Journal of medicinal chemistry, 2014-11, Vol.57 (21), p.8936-8946

2014

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A new type of DNA "light-switch": a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Chemical communications (Cambridge, England), 2014-01, Vol.50 (3), p.311-313

2014

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Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands

Inorganic chemistry, 2017-10, Vol.56 (20), p.12214-12223

2017

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Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer

Journal of materials chemistry. B, Materials for biology and medicine, 2016-01, Vol.4 (3), p.394-408

2016

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The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition

Biomolecules (Basel, Switzerland), 2024-04, Vol.14 (4), p.441

2024

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Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes

Current opinion in chemical biology, 2021-04, Vol.61, p.191-202

2021

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Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy

ACS omega, 2020-08, Vol.5 (30), p.18894-18906

2020

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Panchromatic Osmium Complexes for Photodynamic Therapy: Solutions to Existing Problems and New Questions

Photochemistry and photobiology, 2017-10, Vol.93 (5), p.1326-1328

Glazer, Edith C.

2017

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Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants

Biochemistry (Easton), 2016-06, Vol.55 (25), p.3594-3606

2016

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Metals in Medicine

European journal of inorganic chemistry, 2022-02, Vol.2022 (6), p.n/a

2022

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Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks

Inorganic chemistry, 2014-10, Vol.53 (19), p.10370-10377

2014

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Three Clusters of Conformational States in P450cam Reveal a Multistep Pathway for Closing of the Substrate Access Channel

Biochemistry (Easton), 2011-02, Vol.50 (5), p.693-703

2011

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Superior photodynamic effect of carbon quantum dots through both type I and type II pathways: Detailed comparison study of top-down-synthesized and bottom-up-synthesized carbon quantum dots

Carbon (New York), 2018-12, Vol.140, p.616-623

2018

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Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of "dual action" photoactivated agents

Chemical communications (Cambridge, England), 2018-11, Vol.54 (88), p.12487-12490

2018

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Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures

Chemistry : a European journal, 2016-01, Vol.22 (2), p.550-559

2016

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Light-Activated Metal Complexes that Covalently Modify DNA

Israel journal of chemistry, 2013-06, Vol.53 (6-7), p.391-400

Glazer, Edith C.

2013

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Abstract 4840: The role of the metal scaffold in the development of cytotoxic metal complexes

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4840-4840

Glazer, Edith C.

2016

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Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents

European journal of inorganic chemistry, 2017-03, Vol.2017 (12), p.1687-1694

2017

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Bis-tridentate N‑Heterocyclic Carbene Ru(II) Complexes are Promising New Agents for Photodynamic Therapy

Inorganic chemistry, 2020-07, Vol.59 (13), p.8882-8892

2020

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Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach

Journal of medicinal chemistry, 2023-01, Vol.66 (1), p.398-412

2023

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Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines

European journal of medicinal chemistry, 2018-08, Vol.156, p.790-799

2018

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Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility Through Fine Tuning of Steric, Electronic, and Physiochemical Features

Ru(II) photocages enable precise control over enzyme activity with red light

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Coordination of Hydroxyquinolines to a Ruthenium Bis-dimethyl-phenanthroline Scaffold Radically Improves Potency for Potential as Antineoplastic Agents

A new type of DNA "light-switch": a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands

Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer

The Impact of Inorganic Systems and Photoactive Metal Compounds on Cytochrome P450 Enzymes and Metabolism: From Induction to Inhibition

Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes

Photochemical and Photobiological Properties of Pyridyl-pyrazol(in)e-Based Ruthenium(II) Complexes with Sub-micromolar Cytotoxicity for Phototherapy

Panchromatic Osmium Complexes for Photodynamic Therapy: Solutions to Existing Problems and New Questions

Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants

Metals in Medicine

Modifying Charge and Hydrophilicity of Simple Ru(II) Polypyridyl Complexes Radically Alters Biological Activities: Old Complexes, Surprising New Tricks

Three Clusters of Conformational States in P450cam Reveal a Multistep Pathway for Closing of the Substrate Access Channel

Superior photodynamic effect of carbon quantum dots through both type I and type II pathways: Detailed comparison study of top-down-synthesized and bottom-up-synthesized carbon quantum dots

Ru(ii) complexes with diazine ligands: electronic modulation of the coordinating group is key to the design of "dual action" photoactivated agents

Ruthenium Complex "Light Switches" that are Selective for Different G-Quadruplex Structures

Light-Activated Metal Complexes that Covalently Modify DNA

Abstract 4840: The role of the metal scaffold in the development of cytotoxic metal complexes

Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents

Bis-tridentate N‑Heterocyclic Carbene Ru(II) Complexes are Promising New Agents for Photodynamic Therapy

Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach

Structure-activity relationships of anticancer ruthenium(II) complexes with substituted hydroxyquinolines

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