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Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

Antiviral research, 2015-09, Vol.121, p.47-58

2015

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RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies

Viruses, 2021-03, Vol.13 (4), p.581

2021

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Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

Clinical pharmacology in drug development, 2017-07, Vol.6 (4), p.350-362

2017

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RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

Science translational medicine, 2017-09, Vol.9 (409)

2017

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Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency

The New England journal of medicine, 2022-08, Vol.387 (6), p.514-524

2022

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Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB

Journal of hepatology, 2022-11, Vol.77 (5), p.1287-1298

2022

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RNA Interference Therapy With ARC‐520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

Hepatology (Baltimore, Md.), 2020-07, Vol.72 (1), p.19-31

2020

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Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients

Journal of hepatology, 2018-08, Vol.69 (2), p.378-384

2018

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Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment

Gut, 2022-04, Vol.71 (4), p.789

2022

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Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

Antiviral research, 2015-09, Vol.121, p.97-108

2015

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A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis

Journal of hepatology, 2023-04, Vol.78 (4), p.684-692

2023

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Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease

JCI insight, 2020-06, Vol.5 (12)

2020

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Abnormal Patterns of Insulin Secretion in Non-Insulin-Dependent Diabetes Mellitus

The New England journal of medicine, 1988-05, Vol.318 (19), p.1231-1239

1988

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Fazirsiran for Liver Disease Associated With Alpha

The New England journal of medicine, 2022-08, Vol.387 (6), p.514

2022

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Fazirsiran for Liver Disease Associated with Alpha 1 -Antitrypsin Deficiency

The New England journal of medicine, 2022-08, Vol.387 (6), p.514-524

2022

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Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans

Diabetes (New York, N.Y.), 1990-02, Vol.39 (2), p.175

1990

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Diabetes Due to Secretion of an Abnormal Insulin

The New England journal of medicine, 1980-01, Vol.302 (3), p.129-135

1980

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Pharmacokinetics and pharmacodynamics of dilevalol

Clinical pharmacology and therapeutics, 1989-12, Vol.46 (6), p.648-656

1989

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Duration of Action and Short-Term Hormonal Responses to Enalapril (MK 421) in Normal Subjects

Journal of cardiovascular pharmacology, 1984-05, Vol.6 (3), p.436-441

1984

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Insulin Resistance due to a Defect Distal to the Insulin Receptor: Demonstration in a Patient with Leprechaunism

Proceedings of the National Academy of Sciences - PNAS, 1978-07, Vol.75 (7), p.3469-3473

1978

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Glyburide enhances the responsiveness of the β-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus

The journal of clinical endocrinology and metabolism, 1989-09, Vol.69 (3), p.571-576

1989

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Nifedipine in severely hypertensive patients with congestive heart failure and preserved ventricular systolic function

Archives of internal medicine (1960), 1985-02, Vol.145 (2), p.281

1985

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Symptomatic hypotension following the clonidine suppression test for pheochromocytoma

Archives of internal medicine (1960), 1983-11, Vol.143 (11), p.2195

1983

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Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography

Diabetes care, 1991-07, Vol.14 (7), p.544

1991

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Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia

Metabolism, clinical and experimental, 1986-12, Vol.35 (12), p.1137-1146

1986

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Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies

Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

Fazirsiran for Liver Disease Associated with Alpha1-Antitrypsin Deficiency

Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB

RNA Interference Therapy With ARC‐520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients

Long-term serological, virological and histological responses to RNA inhibition by ARC-520 in Chinese chronic hepatitis B patients on entecavir treatment

Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent

A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis

Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease

Abnormal Patterns of Insulin Secretion in Non-Insulin-Dependent Diabetes Mellitus

Fazirsiran for Liver Disease Associated With Alpha

Fazirsiran for Liver Disease Associated with Alpha 1 -Antitrypsin Deficiency

Change in hexose distribution volume and fractional utilization of [18F]-2-deoxy-2-fluoro-D-glucose in brain during acute hypoglycemia in humans

Diabetes Due to Secretion of an Abnormal Insulin

Pharmacokinetics and pharmacodynamics of dilevalol

Duration of Action and Short-Term Hormonal Responses to Enalapril (MK 421) in Normal Subjects

Insulin Resistance due to a Defect Distal to the Insulin Receptor: Demonstration in a Patient with Leprechaunism

Glyburide enhances the responsiveness of the β-cell to glucose but does not correct the abnormal patterns of insulin secretion in noninsulin-dependent diabetes mellitus

Nifedipine in severely hypertensive patients with congestive heart failure and preserved ventricular systolic function

Symptomatic hypotension following the clonidine suppression test for pheochromocytoma

Hypoglycemia due to surreptitious injection of insulin. Identification of insulin species by high-performance liquid chromatography

Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia

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