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A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications

Expert opinion on therapeutic patents, 2019-07, Vol.29 (7), p.555-578

2019

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Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition

Current medicinal chemistry, 2014, Vol.21 (13), p.1478

2014

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PDE5 inhibitors and their applications

Current medicinal chemistry, 2010-08, Vol.17 (24), p.2564

2010

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[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and Analogues as Potent Antinociceptive Agents

Journal of medicinal chemistry, 2003-03, Vol.46 (6), p.1055-1059

2003

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Selective ACAT inhibitors as promising antihyperlipidemic, antiathero-sclerotic and anti-Alzheimer drugs

Mini reviews in medicinal chemistry, 2003, Vol.3 (6), p.576

2003

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Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

Journal of medicinal chemistry, 1997-05, Vol.40 (10), p.1417-1421

1997

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5,6-Diphenylpyridazine Derivatives as Acyl-CoA:Cholesterol Acyltransferase Inhibitors

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4292-4295

2001

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Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a Potential Substrate for New Aldose Reductase Inhibitors

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.1894-1900

1999

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Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies

European Journal of Medicinal Chemistry, 2000-05, Vol.35 (5), p.463-480

2000

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4,5-Functionalized 6-phenyl-3(2 H)-pyridazinones: synthesis and evaluation of antinociceptive activity

European journal of medicinal chemistry, 1996, Vol.31 (1), p.65-70

1996

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Isoxazolo[3,4- d]pyridazinones and analogues as Leishmania mexicana PDE inhibitors

Farmaco (Società chimica italiana : 1989), 2002-02, Vol.57 (2), p.89-96

2002

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Antinociceptive activity of a 3(2H)-pyridazinone derivative in mice

Life sciences (1973), 1999, Vol.65 (13), p.1381-1394

1999

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5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and Related 4-Amino Compounds: Synthesis and Pharmacological Evaluation

Journal of pharmaceutical sciences, 1991-04, Vol.80 (4), p.341-348

1991

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Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists

Journal of medicinal chemistry, 2001-07, Vol.44 (15), p.2403-2410

2001

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5-Acetyl-2-methyl-4-nitro-6-phenyl-3(2H)-pyridazinone: Versatile Precursor to Hetero-Condensed Pyridazinones

Synthesis (Stuttgart), 1994, Vol.1994 (7), p.669-671

1994

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4-Substituted-5-acetyl-2-methyl-6-phenyl-3(2H)pyridazinones as PGE2 and IL-1 release inhibitors from mouse adherent macrophages

Pharmacological research, 1994-05, Vol.29 (4), p.367-372

1994

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Synthesis and evaluation of some 4,5-disubstituted 6-phenyl-3(2 H)-pyridazinones as hypotensive agents

European journal of medicinal chemistry, 1994, Vol.29 (3), p.249-252

1994

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Heterocyclic-fused 3(2H)-pyridazinones as potent and selective PDE IV inhibitors: Further structure-activity relationships and molecular modelling studies

European journal of medicinal chemistry, 1998-10, Vol.33 (10), p.789-797

1998

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4-Amino-5-substituted-3(2H)-pyridazinones as Orally Active Antinociceptive Agents: Synthesis and Studies on the Mechanism of Action

Journal of medicinal chemistry, 2007-08, Vol.50 (16), p.3945-3953

2007

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Isoxazolo [3,4-d]pyridazin-7(6h)-ones. synthesis of 3-unsubstituted derivatives: A reinvestigation

Tetrahedron letters, 1991-07, Vol.32 (27), p.3229-3230

1991

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Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as PDE 5 Inhibitors Potentially Useful as Peripheral Vasodilator Agents

Journal of enzyme inhibition and medicinal chemistry, 2002-01, Vol.17 (4), p.227-233

2002

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Synthesis and Evaluation of Novel Pyrrolo[2,3-d] and Thieno[2,3-d]Pyridazinones as in Vitro Antiproliferative Agents

Acta chimica Slovenica, 2009-01, Vol.56 (3)

2009

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Chiral resolution and absolute configuration of the enantiomers of 5-acetyl-2-methyl-4-methylsulfinyl-6-phenyl-3(2H)-pyridazinone and evaluation of their platelet aggregation inhibitory activity

Chirality (New York, N.Y.), 1997, Vol.9 (7), p.681-685

1997

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Synthesis and evaluation as platelet aggregation inhibitors of 6-phenyl-2,4-substituted-3(2H)-pyridazinones and their rigid analogues benzo[h]cinnolin-3,5-diones

Drug design and discovery, 1996-03, Vol.14 (1), p.53

1996

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Phenylpiperazinylalkylamino Substituted Pyridazinones as Potent α1 Adrenoceptor Antagonists

Journal of medicinal chemistry, 2001-07, Vol.44 (15), p.2403-2410

2001

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A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications

Development of small molecule non-peptide formyl peptide receptor (FPR) ligands and molecular modeling of their recognition

PDE5 inhibitors and their applications

[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and Analogues as Potent Antinociceptive Agents

Selective ACAT inhibitors as promising antihyperlipidemic, antiathero-sclerotic and anti-Alzheimer drugs

Novel Heterocyclic-Fused Pyridazinones as Potent and Selective Phosphodiesterase IV Inhibitors

5,6-Diphenylpyridazine Derivatives as Acyl-CoA:Cholesterol Acyltransferase Inhibitors

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a Potential Substrate for New Aldose Reductase Inhibitors

Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies

4,5-Functionalized 6-phenyl-3(2 H)-pyridazinones: synthesis and evaluation of antinociceptive activity

Isoxazolo[3,4- d]pyridazinones and analogues as Leishmania mexicana PDE inhibitors

Antinociceptive activity of a 3(2H)-pyridazinone derivative in mice

5-Acyl-6-aryl-4-nitro-3(2H)pyridazinones and Related 4-Amino Compounds: Synthesis and Pharmacological Evaluation

Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists

5-Acetyl-2-methyl-4-nitro-6-phenyl-3(2H)-pyridazinone: Versatile Precursor to Hetero-Condensed Pyridazinones

4-Substituted-5-acetyl-2-methyl-6-phenyl-3(2H)pyridazinones as PGE2 and IL-1 release inhibitors from mouse adherent macrophages

Synthesis and evaluation of some 4,5-disubstituted 6-phenyl-3(2 H)-pyridazinones as hypotensive agents

Heterocyclic-fused 3(2H)-pyridazinones as potent and selective PDE IV inhibitors: Further structure-activity relationships and molecular modelling studies

4-Amino-5-substituted-3(2H)-pyridazinones as Orally Active Antinociceptive Agents: Synthesis and Studies on the Mechanism of Action

Isoxazolo [3,4-d]pyridazin-7(6h)-ones. synthesis of 3-unsubstituted derivatives: A reinvestigation

Synthesis and Evaluation of Some Pyrazolo[3,4-d]pyridazinones and Analogues as PDE 5 Inhibitors Potentially Useful as Peripheral Vasodilator Agents

Synthesis and Evaluation of Novel Pyrrolo[2,3-d] and Thieno[2,3-d]Pyridazinones as in Vitro Antiproliferative Agents

Chiral resolution and absolute configuration of the enantiomers of 5-acetyl-2-methyl-4-methylsulfinyl-6-phenyl-3(2H)-pyridazinone and evaluation of their platelet aggregation inhibitory activity

Synthesis and evaluation as platelet aggregation inhibitors of 6-phenyl-2,4-substituted-3(2H)-pyridazinones and their rigid analogues benzo[h]cinnolin-3,5-diones

Phenylpiperazinylalkylamino Substituted Pyridazinones as Potent α1 Adrenoceptor Antagonists

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