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A biomimetic multicellular model of the airways using primary human cells

Lab on a chip, 2014-01, Vol.14 (17), p.3349-3358

2014

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Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1‑(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

Journal of medicinal chemistry, 2014-09, Vol.57 (18), p.7758-7769

2014

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Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6901-6916

2013

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Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation

Journal of inflammation (London, England), 2009-05, Vol.6 (1), p.15-15

2009

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Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor

ACS chemical neuroscience, 2014-07, Vol.5 (7), p.576-587

2014

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Effect of 1‑Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin‑1 Receptor

ACS chemical neuroscience, 2015-04, Vol.6 (4), p.599-614

2015

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Toward the Development of Bivalent Ligand Probes of Cannabinoid CB1 and Orexin OX1 Receptor Heterodimers

ACS medicinal chemistry letters, 2014-06, Vol.5 (6), p.634-638

2014

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Validation of a High-Throughput Calcium Mobilization Assay for the Human Trace Amine-Associated Receptor 1

SLAS discovery, 2021-01, Vol.26 (1), p.140-150

2021

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Identification of 1‑({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)‑1H‑pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5318-5332

2014

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Identification of N‑[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)‑1H‑indol-1-yl)acetyl]‑l‑leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

Journal of medicinal chemistry, 2014-09, Vol.57 (17), p.7472-7477

2014

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Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2980-2985

2011

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Truncated Orexin Peptides: Structure–Activity Relationship Studies

ACS medicinal chemistry letters, 2013-12, Vol.4 (12), p.1224-1227

2013

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Structure-activity relationship studies on the tetrahydroisoquinoline-based orexin 1 receptor antagonists: The 1-benzyl position

Drug and alcohol dependence, 2015-01, Vol.146, p.e31-e31

2015

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Discovery of N‑{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide Analogues as Selective Kappa Opioid Receptor Antagonists

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4551-4567

2013

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Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.292-296

2015

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The effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the Orexin-1 receptor

Drug and alcohol dependence, 2015-11, Vol.156, p.e244-e245

2015

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Effect of the 3- and 4‑Methyl Groups on the Opioid Receptor Properties of N‑Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines

Journal of medicinal chemistry, 2014-04, Vol.57 (7), p.3140-3147

2014

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The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2

Bioorganic & medicinal chemistry letters, 2015-05, Vol.25 (10), p.2060-2064

2015

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Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents

Psychopharmacology, 2010-06, Vol.210 (2), p.275-284

2010

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Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4- a]pyrazin-3-ones critical for Neuropeptide S antagonist activity

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4064-4067

2008

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Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

ACS chemical neuroscience, 2016-09, Vol.7 (9), p.1225-1231

2016

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Synthesis and evaluation of 1,2,4-methyltriazines as mGluR5 antagonists

Organic & biomolecular chemistry, 2011-06, Vol.9 (11), p.4276-4286

2011

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Amiodarone and its putative metabolites fail to activate wild type hTAAR1

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (20), p.5913-5914

2009

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Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines

Tetrahedron letters, 2011-06, Vol.52 (26), p.3345-3346

2011

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Synthesis and Pharmacological Evaluation of Phenylethynyl[1,2,4]methyltriazines as Analogues of 3-Methyl-6-(phenylethynyl)pyridine

Journal of medicinal chemistry, 2007-07, Vol.50 (14), p.3388-3391

2007

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A biomimetic multicellular model of the airways using primary human cells

Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1‑(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)

Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor

Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation

Synthesis, Pharmacological Characterization, and Structure–Activity Relationship Studies of Small Molecular Agonists for the Orphan GPR88 Receptor

Effect of 1‑Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin‑1 Receptor

Toward the Development of Bivalent Ligand Probes of Cannabinoid CB1 and Orexin OX1 Receptor Heterodimers

Validation of a High-Throughput Calcium Mobilization Assay for the Human Trace Amine-Associated Receptor 1

Identification of 1‑({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)‑1H‑pyrazol-3-yl]carbonyl}amino)cyclohexane Carboxylic Acid as a Selective Nonpeptide Neurotensin Receptor Type 2 Compound

Identification of N‑[(5-{[(4-Methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)‑1H‑indol-1-yl)acetyl]‑l‑leucine (NTRC-824), a Neurotensin-like Nonpeptide Compound Selective for the Neurotensin Receptor Type 2

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists

Truncated Orexin Peptides: Structure–Activity Relationship Studies

Structure-activity relationship studies on the tetrahydroisoquinoline-based orexin 1 receptor antagonists: The 1-benzyl position

Discovery of N‑{4-[(3-Hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide Analogues as Selective Kappa Opioid Receptor Antagonists

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2

The effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the Orexin-1 receptor

Effect of the 3- and 4‑Methyl Groups on the Opioid Receptor Properties of N‑Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2

Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents

Identifying structural features on 1,1-diphenyl-hexahydro-oxazolo[3,4- a]pyrazin-3-ones critical for Neuropeptide S antagonist activity

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2

Synthesis and evaluation of 1,2,4-methyltriazines as mGluR5 antagonists

Amiodarone and its putative metabolites fail to activate wild type hTAAR1

Preparation of a series of 5-methyl-3-(substituted)-[1,2,4]triazines

Synthesis and Pharmacological Evaluation of Phenylethynyl[1,2,4]methyltriazines as Analogues of 3-Methyl-6-(phenylethynyl)pyridine

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