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Tau PET imaging in neurodegenerative tauopathies—still a challenge

Molecular psychiatry, 2019-08, Vol.24 (8), p.1112-1134

2019

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Efficacy, long‐term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan

Neurogastroenterology and motility, 2019-05, Vol.31 (5), p.e13571-n/a

2019

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Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: AβPParc and PSEN1DE9

Molecular psychiatry, 2021-10, Vol.26 (10), p.5609-5619

2021

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Bile acids: short and long term effects in the intestine

Scandinavian journal of gastroenterology, 2010-06, Vol.45 (6), p.645-664

2010

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Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial

The lancet. Gastroenterology & hepatology, 2018-08, Vol.3 (8), p.537-547

2018

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Systematic Review and Meta-analysis: Partial External Biliary Diversion in Progressive Familial Intrahepatic Cholestasis

Journal of pediatric gastroenterology and nutrition, 2020-08, Vol.71 (2), p.176-183

2020

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Impact of elobixibat on serum and fecal bile acid levels and constipation symptoms in patients with chronic constipation

Journal of gastroenterology and hepatology, 2022-05, Vol.37 (5), p.883-890

2022

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Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Alzheimer's research & therapy, 2017-12, Vol.9 (1), p.96-96, Article 96

2017

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Lack of fibrillar amyloid plaques but hypometabolism and astrogliosis in autosomal dominant variant AßPParc Alzheimer's disease

Molecular psychiatry, 2021-10, Vol.26 (10), p.5471-5471

2021

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Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease

Alzheimer's & dementia, 2017-04, Vol.13 (4), p.419-430

2017

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A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans

Hepatology (Baltimore, Md.), 2023-09, Vol.78 (3), p.709-726

2023

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Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

Drug discovery today, 2009-04, Vol.14 (7), p.358-372

2009

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Tau PET imaging in neurodegenerative tauopathies-still a challenge

Molecular psychiatry, 2019-08, Vol.24 (8), p.1112-1134

2019

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Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised by 3 H-THK5117 and 3 H-deprenyl autoradiography

Scientific reports, 2017-04, Vol.7, p.45496

2017

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Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains

Molecular psychiatry, 2023-03, Vol.28 (3), p.1272-1283

2023

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Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation

Scandinavian journal of gastroenterology, 2008, Vol.43 (12), p.1483-1488

2008

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Effects of odevixibat on pruritus and bile acids in children with cholestatic liver disease: Phase 2 study

Clinics and research in hepatology and gastroenterology, 2021-09, Vol.45 (5), p.101751-101751, Article 101751

2021

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P17 Dual ileal/renal-liver bile acid transporter inhibitors with different transporter selectivity in vitro differentially increase faecal and urinary bile acid excretion in organic anion-transporting polypeptide 1a/1b knockout mice in vivo

Gut, 2022-09, Vol.71 (Suppl 3), p.A43-A43

2022

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Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

Brain (London, England : 1878), 2013-07, Vol.136 (Pt 7), p.2217-2227

2013

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Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice

Biochemical and biophysical research communications, 2008-03, Vol.367 (2), p.242-248

2008

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High-throughput magnetic resonance imaging in murine colonic inflammation

Biochemical and biophysical research communications, 2007-04, Vol.355 (4), p.1102-1107

2007

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A novel method to assess gastric accommodation and peristaltic motility in conscious rats

Scandinavian journal of gastroenterology, 2008, Vol.43 (1), p.34-43

2008

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Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters

International immunopharmacology, 2008-01, Vol.8 (1), p.20-27

2008

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Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue

Acta neuropathologica communications, 2015-07, Vol.3, p.40-40

2015

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Novel Method for Study of Gastric Mechanical Functions in Conscious Mice

Digestive diseases and sciences, 2009-02, Vol.54 (2), p.222-231

2009

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Tau PET imaging in neurodegenerative tauopathies—still a challenge

Efficacy, long‐term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan

Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer's disease variants: AβPParc and PSEN1DE9

Bile acids: short and long term effects in the intestine

Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial

Systematic Review and Meta-analysis: Partial External Biliary Diversion in Progressive Familial Intrahepatic Cholestasis

Impact of elobixibat on serum and fecal bile acid levels and constipation symptoms in patients with chronic constipation

Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Lack of fibrillar amyloid plaques but hypometabolism and astrogliosis in autosomal dominant variant AßPParc Alzheimer's disease

Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease

A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

Tau PET imaging in neurodegenerative tauopathies-still a challenge

Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised by 3 H-THK5117 and 3 H-deprenyl autoradiography

Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains

Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation

Effects of odevixibat on pruritus and bile acids in children with cholestatic liver disease: Phase 2 study

P17 Dual ileal/renal-liver bile acid transporter inhibitors with different transporter selectivity in vitro differentially increase faecal and urinary bile acid excretion in organic anion-transporting polypeptide 1a/1b knockout mice in vivo

Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue

Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice

High-throughput magnetic resonance imaging in murine colonic inflammation

A novel method to assess gastric accommodation and peristaltic motility in conscious rats

Dextran sulphate sodium induces acute colitis and alters hepatic function in hamsters

Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue

Novel Method for Study of Gastric Mechanical Functions in Conscious Mice

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