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Prostanoid receptor antagonists: development strategies and therapeutic applications

British journal of pharmacology, 2009-09, Vol.158 (1), p.104-145

2009

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Can the anti‐inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?

British journal of pharmacology, 2008-10, Vol.155 (3), p.288-290

Giembycz, M A

2008

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Beyond the dogma : novel β2-adrenoceptor signalling in the airways

The European respiratory journal, 2006-06, Vol.27 (6), p.1286-1306

2006

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An analysis of glucocorticoid receptor‐mediated gene expression in BEAS‐2B human airway epithelial cells identifies distinct, ligand‐directed, transcription profiles with implications for asthma therapeutics

British journal of pharmacology, 2015-03, Vol.172 (5), p.1360-1378

2015

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A Holy Grail of asthma management: toward understanding how long‐acting β 2 ‐adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

British journal of pharmacology, 2009-01, Vol.153 (6), p.1090-1104

2009

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The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner

British journal of pharmacology, 2015-05, Vol.172 (10), p.2634-2653

2015

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Phosphodiesterase 7A: a new therapeutic target for alleviating chronic inflammation?

Current pharmaceutical design, 2006-09, Vol.12 (25), p.3207-3220

2006

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A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

British journal of pharmacology, 2008-03, Vol.153 (6), p.1090

2008

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Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease

Expert opinion on investigational drugs, 2001-07, Vol.10 (7), p.1361-1379

Giembycz, Mark A

2001

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Inhibitory effect of p38 mitogen‐activated protein kinase inhibitors on cytokine release from human macrophages

British journal of pharmacology, 2006-10, Vol.149 (4), p.393-404

2006

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Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL‐8 production in human colonic epithelial cell lines

British journal of pharmacology, 2009-02, Vol.156 (3), p.475-485

2009

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Phosphodiesterase 4 inhibitors and the treatment of asthma : Where are we now and where do we go from here?

Drugs (New York, N.Y.), 2000-02, Vol.59 (2), p.193-212

GIEMBYCZ, M. A

2000

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Enhancement of inflammatory mediator release by β2‐adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action

British journal of pharmacology, 2010-05, Vol.160 (2), p.410-420

2010

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Potentiation of NF‐κB‐dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells

British journal of pharmacology, 2007-11, Vol.152 (6), p.891-902

2007

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Pharmacology of the eosinophil

Pharmacological reviews, 1999-06, Vol.51 (2), p.213

1999

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Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis

British journal of pharmacology, 2000-08, Vol.130 (7), p.1433-1452

2000

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Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

British journal of pharmacology, 1996-08, Vol.118 (8), p.1945-1958

1996

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β2-Agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

The European respiratory journal, 2010-03, Vol.35 (3), p.647-654

2010

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Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

The European respiratory journal, 2010-03, Vol.35 (3), p.647-654

2010

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Prostaglandin E 2 couples through EP 4 prostanoid receptors to induce IL‐8 production in human colonic epithelial cell lines

British journal of pharmacology, 2009-02, Vol.156 (3), p.475-485

2009

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Enhancement of inflammatory mediator release by β 2 ‐adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action

British journal of pharmacology, 2010-05, Vol.160 (2), p.410-420

2010

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Adenosine 3',5'-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL-5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A

The Journal of immunology (1950), 2001-08, Vol.167 (4), p.2074-2080

2001

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Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

Molecular pharmacology, 2004-12, Vol.66 (6), p.1679-1689

2004

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p38 MAP kinase and MKK‐1 co‐operate in the generation of GM‐CSF from LPS‐stimulated human monocytes by an NF‐κB‐independent mechanism

British journal of pharmacology, 2000-11, Vol.131 (6), p.1143-1153

2000

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Release of granulocyte‐macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone

British journal of pharmacology, 1997-02, Vol.120 (4), p.545-546

1997

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Prostanoid receptor antagonists: development strategies and therapeutic applications

Can the anti‐inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?

Beyond the dogma : novel β2-adrenoceptor signalling in the airways

An analysis of glucocorticoid receptor‐mediated gene expression in BEAS‐2B human airway epithelial cells identifies distinct, ligand‐directed, transcription profiles with implications for asthma therapeutics

A Holy Grail of asthma management: toward understanding how long‐acting β 2 ‐adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

The long‐acting β2‐adrenoceptor agonist, indacaterol, enhances glucocorticoid receptor‐mediated transcription in human airway epithelial cells in a gene‐ and agonist‐dependent manner

Phosphodiesterase 7A: a new therapeutic target for alleviating chronic inflammation?

A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease

Inhibitory effect of p38 mitogen‐activated protein kinase inhibitors on cytokine release from human macrophages

Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL‐8 production in human colonic epithelial cell lines

Phosphodiesterase 4 inhibitors and the treatment of asthma : Where are we now and where do we go from here?

Enhancement of inflammatory mediator release by β2‐adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action

Potentiation of NF‐κB‐dependent transcription and inflammatory mediator release by histamine in human airway epithelial cells

Pharmacology of the eosinophil

Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis

Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2

β2-Agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway

Prostaglandin E 2 couples through EP 4 prostanoid receptors to induce IL‐8 production in human colonic epithelial cell lines

Enhancement of inflammatory mediator release by β 2 ‐adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action

Adenosine 3',5'-Cyclic Monophosphate (cAMP)-Dependent Inhibition of IL-5 from Human T Lymphocytes Is Not Mediated by the cAMP-Dependent Protein Kinase A

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

p38 MAP kinase and MKK‐1 co‐operate in the generation of GM‐CSF from LPS‐stimulated human monocytes by an NF‐κB‐independent mechanism

Release of granulocyte‐macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone

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