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Modulating IgG effector function by Fc glycan engineering

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (13), p.3485-3490

2017

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Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling

The Journal of biological chemistry, 2016-08, Vol.291 (32), p.16508-16518

2016

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Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

The Journal of clinical investigation, 2015-11, Vol.125 (11), p.4160-4170

2015

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Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (47), p.12023-12027

2018

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Endo-F3 Glycosynthase Mutants Enable Chemoenzymatic Synthesis of Core-fucosylated Triantennary Complex Type Glycopeptides and Glycoproteins

The Journal of biological chemistry, 2016-04, Vol.291 (17), p.9356-9370

2016

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Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses

Cell chemical biology, 2017-12, Vol.24 (12), p.1513-1522.e4

2017

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Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

mAbs, 2023, Vol.15 (1), p.2160227

2023

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Principal component analysis for automated classification of 2D spectra and interferograms of protein therapeutics: influence of noise, reconstruction details, and data preparation

Journal of biomolecular NMR, 2020-11, Vol.74 (10-11), p.643-656

2020

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Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs

Frontiers in molecular biosciences, 2022-04, Vol.9, p.789973-789973

2022

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Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies

Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (18), p.6714-6719

2014

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Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies

International journal of molecular sciences, 2018-01, Vol.19 (2), p.421

2018

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Chemoenzymatic Glyco-engineering of Monoclonal Antibodies

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1321, p.375

2015

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Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags

Bioconjugate chemistry, 2014-04, Vol.25 (4), p.788-795

2014

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Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1 H, 13 C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

Analytical chemistry (Washington), 2020-05, Vol.92 (9), p.6366-6373

2020

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Heterologous recombinant expression of non-originator NISTmAb

mAbs, 2018-08, Vol.10 (6), p.922-933

2018

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Comparative Analysis of 1D PROFILE and 2D 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

Analytical chemistry (Washington), 2020-04, Vol.92 (9), p.6366-6373

2020

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Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

Analytical chemistry (Washington), 2020-05, Vol.92 (9), p.6366-6373

2020

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Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

mAbs, 2023, Vol.15 (1)

2023

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Heterologous recombinant expression of non-originator NISTmAb

mAbs, 2018, Vol.10 (6), p.922-933

2018

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Genome Sequence of the Biocontrol Strain Pseudomonas fluorescens F113

Journal of Bacteriology, 2012-03, Vol.194 (5), p.1273-1274

2012

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Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease

Journal of the Royal Society interface, 2017-02, Vol.14 (127)

2017

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Low Coronary Wall Shear Stress Is Associated With Severe Endothelial Dysfunction in Patients With Nonobstructive Coronary Artery Disease

JACC. Cardiovascular interventions, 2018-10, Vol.11 (20), p.2072-2080

2018

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Effects of wall motion and compliance on flow patterns in the ascending aorta

Journal of biomechanical engineering, 2003-06, Vol.125 (3), p.347

2003

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Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

Annals of biomedical engineering, 2015-01, Vol.43 (1), p.94-106

2015

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Fragment-based and structure-guided discovery of perforin inhibitors

European journal of medicinal chemistry, 2023-12, Vol.261, p.115786-115786, Article 115786

2023

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Modulating IgG effector function by Fc glycan engineering

Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling

Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

Endo-F3 Glycosynthase Mutants Enable Chemoenzymatic Synthesis of Core-fucosylated Triantennary Complex Type Glycopeptides and Glycoproteins

Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses

Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

Principal component analysis for automated classification of 2D spectra and interferograms of protein therapeutics: influence of noise, reconstruction details, and data preparation

Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs

Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies

Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies

Chemoenzymatic Glyco-engineering of Monoclonal Antibodies

Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags

Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1 H, 13 C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

Heterologous recombinant expression of non-originator NISTmAb

Comparative Analysis of 1D PROFILE and 2D 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

Comparative Analysis of One-Dimensional Protein Fingerprint by Line Shape Enhancement and Two-Dimensional 1H,13C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb

Heterologous recombinant expression of non-originator NISTmAb

Genome Sequence of the Biocontrol Strain Pseudomonas fluorescens F113

Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease

Low Coronary Wall Shear Stress Is Associated With Severe Endothelial Dysfunction in Patients With Nonobstructive Coronary Artery Disease

Effects of wall motion and compliance on flow patterns in the ascending aorta

Focal Association Between Wall Shear Stress and Clinical Coronary Artery Disease Progression

Fragment-based and structure-guided discovery of perforin inhibitors

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