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Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck

Annals of oncology, 2013-01, Vol.24 (1), p.220-225

2013

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Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

Neurology, 2009-08, Vol.73 (6), p.423-429

2009

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Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

Neurochemistry international, 2016-10, Vol.99, p.72-84

2016

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Clinical spectrum of succinic semialdehyde dehydrogenase deficiency

Neurology, 2003-05, Vol.60 (9), p.1413-1417

2003

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Succinic semialdehyde dehydrogenase deficiency: Lessons from mice and men

Journal of inherited metabolic disease, 2009-06, Vol.32 (3), p.343-352

2009

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Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin‐associated ocular toxicity?

Clinical pharmacology and therapeutics, 2017-04, Vol.101 (4), p.458-461

2017

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Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder

Toxicology in vitro, 2018-02, Vol.46, p.203-212

2018

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Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Biochimica et biophysica acta. Molecular basis of disease, 2017-01, Vol.1863 (1), p.33-42

2017

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Response assessment by combined PET–CT scan versus CT scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy

Annals of oncology, 2010-11, Vol.21 (11), p.2278-2283

2010

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Correlation of blood biomarkers with age informs pathomechanisms in succinic semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Journal of inherited metabolic disease, 2016-11, Vol.39 (6), p.795-800

2016

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In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding

Toxicology in vitro, 2017-04, Vol.40, p.196-202

2017

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Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

Journal of neurochemistry, 2007-12, Vol.103 (5), p.2077-2091

2007

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Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons

Psychopharmacologia, 2009-06, Vol.204 (3), p.465-476

2009

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Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

Pharmacology research & perspectives, 2019-02, Vol.7 (1), p.e00456-n/a

2019

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From the street to the brain: neurobiology of the recreational drug γ-hydroxybutyric acid

Trends in pharmacological sciences (Regular ed.), 2004, Vol.25 (1), p.29-34

2004

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Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy

Pharmacology, biochemistry and behavior, 2004-11, Vol.79 (3), p.547-553

2004

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Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome

Journal of inherited metabolic disease, 2007-11, Vol.30 (6), p.888-895

2007

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Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer

Annals of oncology, 2011-11, Vol.22 (11), p.2482-2488

2011

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Clinical and dosimetric factors associated with a prolonged feeding tube requirement in patients treated with chemoradiotherapy (CRT) for head and neck cancers

Annals of oncology, 2010-01, Vol.21 (1), p.145-151

2010

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Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase : Relevance to d-2-hydroxyglutaric and γ-hydroxybutyric acidurias

Journal of inherited metabolic disease, 2005-12, Vol.28 (6), p.921-930

2005

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Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice

Journal of inherited metabolic disease, 2007-10, Vol.30 (5), p.800-810

2007

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SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex

Journal of inherited metabolic disease, 2008-12, Vol.31 (6), p.662-668

2008

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Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: results from the Eastern Cooperative Oncology Group

Cancer chemotherapy and pharmacology, 2011-10, Vol.68 (4), p.863-870

2011

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Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency ( Aldh5a1 −/− mice)

Neurochemistry international, 2007-03, Vol.50 (4), p.653-659

2007

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Novel insights into L-2-hydroxyglutaric aciduria: Mass isotopomer studies reveal 2-oxoglutaric acid as the metabolic precursor of L-2-hydroxyglutaric acid

Journal of inherited metabolic disease, 2007-10, Vol.30 (5), p.690-693

2007

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Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck

Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency

Succinic semialdehyde dehydrogenase deficiency (SSADHD): Pathophysiological complexity and multifactorial trait associations in a rare monogenic disorder of GABA metabolism

Clinical spectrum of succinic semialdehyde dehydrogenase deficiency

Succinic semialdehyde dehydrogenase deficiency: Lessons from mice and men

Aberrant mTOR signaling and disrupted autophagy: The missing link in potential vigabatrin‐associated ocular toxicity?

Toxicologic/transport properties of NCS-382, a γ-hydroxybutyrate (GHB) receptor ligand, in neuronal and epithelial cells: Therapeutic implications for SSADH deficiency, a GABA metabolic disorder

Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

Response assessment by combined PET–CT scan versus CT scan alone using RECIST in patients with locally advanced head and neck cancer treated with chemoradiotherapy

Correlation of blood biomarkers with age informs pathomechanisms in succinic semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism

In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding

Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling

Behavioral effects and pharmacokinetics of gamma-hydroxybutyrate (GHB) precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in baboons

Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use‐limiting visual field defects

From the street to the brain: neurobiology of the recreational drug γ-hydroxybutyric acid

Absence seizures in succinic semialdehyde dehydrogenase deficient mice: a model of juvenile absence epilepsy

Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome

Phase I trial of pemetrexed in combination with cetuximab and concurrent radiotherapy in patients with head and neck cancer

Clinical and dosimetric factors associated with a prolonged feeding tube requirement in patients treated with chemoradiotherapy (CRT) for head and neck cancers

Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase : Relevance to d-2-hydroxyglutaric and γ-hydroxybutyric acidurias

Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice

SSADH deficiency leads to elevated extracellular GABA levels and increased GABAergic neurotransmission in the mouse cerebral cortex

Genetic variation in radiation and platinum pathways predicts severe acute radiation toxicity in patients with esophageal adenocarcinoma treated with cisplatin-based preoperative radiochemotherapy: results from the Eastern Cooperative Oncology Group

Enzymatic and metabolic evidence for a region specific mitochondrial dysfunction in brains of murine succinic semialdehyde dehydrogenase deficiency ( Aldh5a1 −/− mice)

Novel insights into L-2-hydroxyglutaric aciduria: Mass isotopomer studies reveal 2-oxoglutaric acid as the metabolic precursor of L-2-hydroxyglutaric acid

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