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A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile

PloS one, 2011-02, Vol.6 (2), p.e16703

2011

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Overview of an Interlaboratory Collaboration on Evaluating the Effects of Model Hepatotoxicants on Hepatic Gene Expression

Environmental health perspectives, 2004-03, Vol.112 (4), p.423-427

2004

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In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein

Drug metabolism and disposition, 2009-02, Vol.37 (2), p.391

2009

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Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

Drug metabolism and disposition, 2002-09, Vol.30 (9), p.1029

2002

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Transcriptional Regulation of the Human Pregnane-X Receptor

Drug metabolism reviews, 2006, Vol.38 (1-2), p.31-49

2006

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Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth

Pharmacogenetics and genomics, 2006-09, Vol.16 (9), p.647-658

2006

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Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.233

2005

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Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1499

2001

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Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro-in vivo extrapolations (IVIVE)

Xenobiotica, 2007-11, Vol.37 (10-11), p.1013-1014

2007

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The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1

Toxicology and applied pharmacology, 2009-02, Vol.235 (1), p.124-134

2009

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Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

Drug metabolism and disposition, 2004-05, Vol.32 (5), p.525

2004

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Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors

Drug metabolism and disposition, 2000-05, Vol.28 (5), p.493

2000

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The human karyopherin α2 promoter is responsive to oxidative stress

Toxicology (Amsterdam), 2008, Vol.253 (1), p.9-10

2008

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Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for leydig cell carcinogenesis

Toxicology and applied pharmacology, 2003-10, Vol.192 (2), p.154-163

2003

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Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

Biochemical pharmacology, 2004, Vol.67 (1), p.107-118

2004

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Receptor-dependent regulation of the CYP3A4 gene

Toxicology (Amsterdam), 2002-12, Vol.181, p.199-202

2002

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Comparative aspects of the mammalian cytochrome P450 IV gene family

Xenobiotica, 1989, Vol.19 (10), p.1123-1148

Gordon Gibson, G.

1989

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Peroxisome Proliferators and Cytochrome P4504A Induction

Annals of the New York Academy of Sciences, 1996-01, Vol.804 (1), p.328-340

GORDON GIBSON, G.

1996

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Differential gene expression in drug metabolism and toxicology: practicalities, problems and potential

Xenobiotica, 1999-07, Vol.29 (7), p.655-691

1999

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The Effect of Peroxisome Prouferators on Microsomal. Peroxisomal, and Mitochondrial Enzyme Activities in the Liver and Kidney

Drug metabolism reviews, 1987, Vol.18 (4), p.441-515

1987

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A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16[alpha]-Carbonitrile

PloS one, 2011-02, Vol.6 (2), p.e16703

2011

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Co-induction of cytochrome P4504A1 and peroxisome proliferation: A causal or casual relationship?

Xenobiotica, 1992, Vol.22 (9-10), p.1101-1109

Gordon Gibson, G.

1992

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Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

Biochemical journal, 1982-04, Vol.203 (1), p.161-168

1982

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Bifonazole, but not the structurally-related clotrimazole, induces both peroxisome proliferation and members of the cytochrome P4504A sub-family in rat liver

Toxicology (Amsterdam), 1996-01, Vol.106 (1), p.19-26

1996

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[34] Induction protocols for the cytochrome P450IVA subfamily in animals and primary hepatocyte cultures

Methods in Enzymology, 1991, Vol.206, p.353-364

1991

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A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile

Overview of an Interlaboratory Collaboration on Evaluating the Effects of Model Hepatotoxicants on Hepatic Gene Expression

In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

Transcriptional Regulation of the Human Pregnane-X Receptor

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression

Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers

Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro-in vivo extrapolations (IVIVE)

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1

Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors

The human karyopherin α2 promoter is responsive to oxidative stress

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for leydig cell carcinogenesis

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

Receptor-dependent regulation of the CYP3A4 gene

Comparative aspects of the mammalian cytochrome P450 IV gene family

Peroxisome Proliferators and Cytochrome P4504A Induction

Differential gene expression in drug metabolism and toxicology: practicalities, problems and potential

The Effect of Peroxisome Prouferators on Microsomal. Peroxisomal, and Mitochondrial Enzyme Activities in the Liver and Kidney

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16[alpha]-Carbonitrile

Co-induction of cytochrome P4504A1 and peroxisome proliferation: A causal or casual relationship?

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

Bifonazole, but not the structurally-related clotrimazole, induces both peroxisome proliferation and members of the cytochrome P4504A sub-family in rat liver

[34] Induction protocols for the cytochrome P450IVA subfamily in animals and primary hepatocyte cultures

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