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Acute Effects of Atypical Antipsychotics on Whole-Body Insulin Resistance in Rats: Implications for Adverse Metabolic Effects

Neuropsychopharmacology (New York, N.Y.), 2007-02, Vol.32 (2), p.289-297

2007

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The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2537-2541

2009

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Identification of a novel glucose transporter-like protein---GLUT-12

American journal of physiology: endocrinology and metabolism, 2002-03, Vol.282 (3), p.E733-E738

2002

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Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

Bioorganic & medicinal chemistry, 2013-09, Vol.21 (17), p.5081-5097

2013

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Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform

PloS one, 2011-11, Vol.6 (11), p.e27009-e27009

2011

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Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (20), p.6122-6125

2011

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Physiochemical drug properties associated with in vivo toxicological outcomes

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (17), p.4872-4875

2008

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Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway

Diabetes (New York, N.Y.), 1997-11, Vol.46 (11), p.1915-1919

1997

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Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

American journal of physiology: endocrinology and metabolism, 2000-11, Vol.279 (5), p.E1104-E1113

2000

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Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans

American journal of physiology: Gastrointestinal and liver physiology, 2013-06, Vol.304 (11), p.G958-G969

2013

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Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors

The Journal of pharmacology and experimental therapeutics, 2006-06, Vol.317 (3), p.1230-1237

2006

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Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets : Role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia

Diabetes (New York, N.Y.), 2005-05, Vol.54 (5), p.1552-1558

2005

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Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

ACS medicinal chemistry letters, 2011-05, Vol.2 (5), p.407-412

2011

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The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic ob/ob Mouse

Journal of cerebral blood flow and metabolism, 2010-02, Vol.30 (2), p.352-360

2010

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The Glitazone Family of Antidiabetic Agents

Current pharmaceutical design, 1996-02, Vol.2 (1), p.85-102

1996

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Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Journal of lipid research, 2005-03, Vol.46 (3), p.547-563

2005

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Coat color and its effect on preference for the scent marks of opposite-sex conspecifics in the meadow vole Microtus pennsylvanicus

Current zoology, 2012-04, Vol.58 (2), p.221-227

2012

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5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization

Applied catalysis. B, Environmental, 2005-01, Vol.15 (2), p.459-465

2005

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GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure

Diabetes (New York, N.Y.), 2001-03, Vol.50 (3), p.593-600

2001

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Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter

American journal of physiology: endocrinology and metabolism, 2001-03, Vol.280 (3), p.E420-E427

2001

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Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors

American journal of physiology: endocrinology and metabolism, 2005-09, Vol.289 (3), p.E366-E372

2005

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Transgenic Mice Expressing the Human GLUT4/Muscle-Fat Facilitative Glucose Transporter Protein Exhibit Efficient Glycemic Control

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (23), p.11346-11350

1993

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Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets

Diabetes (New York, N.Y.), 2005-05, Vol.54 (5), p.1552-1558

2005

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Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter

American journal of physiology: endocrinology and metabolism, 2001-03, Vol.43 (3), p.E420-E427

2001

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Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

American journal of physiology: endocrinology and metabolism, 2000-11, Vol.42 (5), p.E1104-E1113

2000

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Acute Effects of Atypical Antipsychotics on Whole-Body Insulin Resistance in Rats: Implications for Adverse Metabolic Effects

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

Identification of a novel glucose transporter-like protein---GLUT-12

Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitor

Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platform

Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3- d]pyrimidine core

Physiochemical drug properties associated with in vivo toxicological outcomes

Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway

Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans

Establishment of correlation between in vitro enzyme binding potency and in vivo pharmacological activity: application to liver glycogen phosphorylase a inhibitors

Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets : Role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

The PPAR-γ Agonist, Darglitazone, Restores Acute Inflammatory Responses to Cerebral Hypoxia–Ischemia in the Diabetic ob/ob Mouse

The Glitazone Family of Antidiabetic Agents

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Coat color and its effect on preference for the scent marks of opposite-sex conspecifics in the meadow vole Microtus pennsylvanicus

5-Chloroindoloyl glycine amide inhibitors of glycogen phosphorylase: synthesis, in vitro, in vivo, and X-ray crystallographic characterization

GLUT4 Overexpression in db/db Mice Dose-Dependently Ameliorates Diabetes But Is Not a Lifelong Cure

Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter

Endogenous effectors of human liver glycogen phosphorylase modulate effects of indole-site inhibitors

Transgenic Mice Expressing the Human GLUT4/Muscle-Fat Facilitative Glucose Transporter Protein Exhibit Efficient Glycemic Control

Inhibitory Effects of Antipsychotics on Carbachol-Enhanced Insulin Secretion From Perifused Rat Islets

Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter

Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

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