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Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review

Biotechnology and bioengineering, 2020-10, Vol.117 (10), p.3182-3198

2020

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Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

Biotechnology and bioengineering, 2010-02, Vol.105 (2), p.306-316

2010

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Evaluation of eco‐friendly zwitterionic detergents for enveloped virus inactivation

Biotechnology and bioengineering, 2017-04, Vol.114 (4), p.813-820

2017

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Emerging biomaterials for downstream manufacturing of therapeutic proteins

Acta biomaterialia, 2019-09, Vol.95, p.73-90

2019

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Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification

mAbs, 2019-11, Vol.11 (8), p.1479-1491

2019

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Protection of therapeutic antibodies from visible light induced degradation: Use safe light in manufacturing and storage

European journal of pharmaceutics and biopharmaceutics, 2018-06, Vol.127, p.37-43

2018

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Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

mAbs, 2020-01, Vol.12 (1), p.1770669-1770669

2020

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Model assisted comparison of Protein A resins and multi-column chromatography for capture processes

Journal of biotechnology, 2018-11, Vol.285, p.64-73

2018

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Metabolic understanding of disulfide reduction during monoclonal antibody production

Applied microbiology and biotechnology, 2020-11, Vol.104 (22), p.9655-9669

2020

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Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

mAbs, 2020-01, Vol.12 (1), p.1829338-1829338

2020

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Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

mAbs, 2021-01, Vol.13 (1), p.1963094-1963094

2021

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Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

mAbs, 2020-01, Vol.12 (1), p.1829336-1829336

2020

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On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

mAbs, 2020-01, Vol.12 (1), p.1829333-1829333

2020

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Hydrophobic interaction chromatography in continuous flow-through mode for product-related variant removal

Journal of Chromatography A, 2024-11, Vol.1736, p.465356, Article 465356

2024

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Antibody disulfide bond reduction and recovery during biopharmaceutical process development—A review

Biotechnology and bioengineering, 2021-08, Vol.118 (8), p.2829-2844

2021

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Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography

Journal of Chromatography A, 2022-12, Vol.1686, p.463652, Article 463652

2022

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Modeling and techno-economic analysis of downstream manufacturing process intensification strategies for existing biopharmaceutical facilities

Journal of Chromatography A, 2024-11, Vol.1737, p.465431, Article 465431

2024

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Maximizing the functional lifetime of Protein A resins

Biotechnology progress, 2017-05, Vol.33 (3), p.708-715

2017

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Experimental Design of the Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) Unit for the Separation of PEGylated Proteins

Industrial & engineering chemistry research, 2021-07, Vol.60 (29), p.10764-10776

2021

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Role of the gradient slope during the product internal recycling for the multicolumn countercurrent solvent gradient purification of PEGylated proteins

Journal of Chromatography A, 2023-03, Vol.1692, p.463868, Article 463868

2023

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Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer

Biotechnology progress, 2023-01, Vol.39 (1), p.e3306-n/a

2023

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Hydrophobic property of cation-exchange resins affects monoclonal antibody aggregation

Journal of Chromatography A, 2020-11, Vol.1631, p.461573, Article 461573

2020

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Affinity precipitation of monoclonal antibodies using ELP-Z in the elution without resolubilization mode

Journal of biotechnology, 2021-09, Vol.338, p.1-4

2021

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Preparative protein purification on underivatized silica

Biotechnology and bioengineering, 2004-08, Vol.87 (3), p.413-423

2004

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Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device

Journal of Chromatography A, 2021-08, Vol.1652, p.462375, Article 462375

2021

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Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review

Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development

Evaluation of eco‐friendly zwitterionic detergents for enveloped virus inactivation

Emerging biomaterials for downstream manufacturing of therapeutic proteins

Protein aggregation and mitigation strategy in low pH viral inactivation for monoclonal antibody purification

Protection of therapeutic antibodies from visible light induced degradation: Use safe light in manufacturing and storage

Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study

Model assisted comparison of Protein A resins and multi-column chromatography for capture processes

Metabolic understanding of disulfide reduction during monoclonal antibody production

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics

Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses

On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies

Hydrophobic interaction chromatography in continuous flow-through mode for product-related variant removal

Antibody disulfide bond reduction and recovery during biopharmaceutical process development—A review

Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography

Modeling and techno-economic analysis of downstream manufacturing process intensification strategies for existing biopharmaceutical facilities

Maximizing the functional lifetime of Protein A resins

Experimental Design of the Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) Unit for the Separation of PEGylated Proteins

Role of the gradient slope during the product internal recycling for the multicolumn countercurrent solvent gradient purification of PEGylated proteins

Use of Monte Carlo simulations for improved facility fit planning in downstream biomanufacturing and technology transfer

Hydrophobic property of cation-exchange resins affects monoclonal antibody aggregation

Affinity precipitation of monoclonal antibodies using ELP-Z in the elution without resolubilization mode

Preparative protein purification on underivatized silica

Fast and high-resolution purification of a PEGylated protein using a z2 laterally-fed membrane chromatography device

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