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Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene

Scientific reports, 2019-04, Vol.9 (1), p.6663, Article 6663

2019

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Drug disposition in pathophysiological conditions

Current drug metabolism, 2012-11, Vol.13 (9), p.1327-1344

2012

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Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro

Drug metabolism and disposition, 2018-04, Vol.46 (4), p.397-404

2018

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Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review

Expert opinion on drug metabolism & toxicology, 2017-09, Vol.13 (9), p.901-923

2017

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Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

Life sciences (1973), 2011-07, Vol.89 (1-2), p.57-64

2011

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Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan’s Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea

Current cancer drug targets, 2019-01, Vol.19 (7), p.551-560

2019

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Neratinib reduces CytochromP450 3A enzymes in mouse intestine

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.05264

2021

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Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-α) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes

The Journal of Toxicological Sciences, 2010, Vol.35(2), pp.163-173

2010

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Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes

Drug metabolism and disposition, 2011-05, Vol.39 (5), p.874-881

2011

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Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid

Archives of biochemistry and biophysics, 2009-01, Vol.481 (1), p.123-130

2009

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Impact of hepatic malignancy on CYP3A4 gene expression

The Journal of surgical research, 2012-12, Vol.178 (2), p.768-772

2012

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Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein

Drug metabolism and disposition, 2008-01, Vol.36 (1), p.95-101

2008

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Differential Regulation of Hepatic UDP‐glucuronosyltransferase (UGT) 1A1 by Toll‐like Receptors during Irinotecan‐induced Steatosis

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Induction of TAK (Cyclin T1/P-TEFb) in Purified Resting CD4+ T Lymphocytes by Combination of Cytokines

Journal of Virology, 2001-12, Vol.75 (23), p.11336-11343

2001

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Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea

Food and chemical toxicology, 2022-08, Vol.166, p.113246, Article 113246

2022

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Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity

Expert opinion on drug metabolism & toxicology, 2020-11, Vol.16 (11), p.1109-1124

2020

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Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions

Expert opinion on drug metabolism & toxicology, 2017-06, Vol.13 (6), p.605-616

2017

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Corrigendum to “Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea” [Food Chem. Toxicol. 166 (2022) 113246]

Food and chemical toxicology, 2023-01, Vol.171, p.113547-113547, Article 113547

2023

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Neratinib causes non-recoverable gut injury and reduces intestinal cytochrome P450 3A enzyme in mice

Toxicology research (Cambridge), 2022-02, Vol.11 (1), p.184-194

2022

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Development of a physiologically based pharmacokinetic model to predict irinotecan disposition during inflammation

Chemico-biological interactions, 2022-06, Vol.360, p.109946, Article 109946

2022

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Altered Expression/Activity of Cytochrome P450 (CYP) 3A4 Enzyme: Implications in Drug Safety and Efficacy

Journal of clinical trials, 2016, Vol.6 (1)

Ghose, Romi

2016

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Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice

Life sciences (1973), 2015-10, Vol.139, p.132-138

2015

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Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt

Toxicology and applied pharmacology, 2020-07, Vol.398, p.115032-115032, Article 115032

2020

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Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model

Chemico-biological interactions, 2020-01, Vol.316, p.108933-108933, Article 108933

2020

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Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A

Expert review of vaccines, 2021-05, Vol.20 (5), p.623-634

2021

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Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene

Drug disposition in pathophysiological conditions

Role of c-Jun-N-Terminal Kinase in Pregnane X Receptor-Mediated Induction of Human Cytochrome P4503A4 In Vitro

Clarifying busulfan metabolism and drug interactions to support new therapeutic drug monitoring strategies: a comprehensive review

Role of high-fat diet in regulation of gene expression of drug metabolizing enzymes and transporters

Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan’s Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea

Neratinib reduces CytochromP450 3A enzymes in mouse intestine

Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-α) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes

Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes

Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid

Impact of hepatic malignancy on CYP3A4 gene expression

Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein

Differential Regulation of Hepatic UDP‐glucuronosyltransferase (UGT) 1A1 by Toll‐like Receptors during Irinotecan‐induced Steatosis

Induction of TAK (Cyclin T1/P-TEFb) in Purified Resting CD4+ T Lymphocytes by Combination of Cytokines

Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea

Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity

Regulation of drug-metabolizing enzymes in infectious and inflammatory disease: implications for biologics-small molecule drug interactions

Corrigendum to “Irinotecan decreases intestinal UDP-glucuronosyltransferase (UGT) 1A1 via TLR4/MyD88 pathway prior to the onset of diarrhea” [Food Chem. Toxicol. 166 (2022) 113246]

Neratinib causes non-recoverable gut injury and reduces intestinal cytochrome P450 3A enzyme in mice

Development of a physiologically based pharmacokinetic model to predict irinotecan disposition during inflammation

Altered Expression/Activity of Cytochrome P450 (CYP) 3A4 Enzyme: Implications in Drug Safety and Efficacy

Impact of obesity on accumulation of the toxic irinotecan metabolite, SN-38, in mice

Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt

Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model

Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A

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